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Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Additionally we are shipping Histamine Receptor H4 Antibodies (73) and Histamine Receptor H4 Kits (14) and many more products for this protein.
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Molecular modelling studies, including molecular dynamic simulations and calculation of Gibbs energy of solvation of hH3R (show HRH3 Proteins) and hH4R, were studied.
HRH4 was increased in clinically-isolated syndrome and different stages of multiple sclerosis compared to health control.
No evidence was found for the presence of histamine H4 receptor in monocytes.
In neutrophils, the H4 receptor may block signals emanating from Mac-1 (show ITGAM Proteins)-controlling degranulation. Engagement of the H4 receptor by selective agonists blocked Mac-1 (show ITGAM Proteins)-dependent activation of p38 MAPK (show MAPK14 Proteins).
The activation of H4R in human mast cells produced not only inflammatory mediators that are associated with allergic reactions but also other inflammatory conditions.
Histamine through the histamine H4 receptor exhibits a crucial role in breast tumour progression.
Obtained results allow for statement that developed cellular model may be successfully employed in search for new compounds active at histamine H4 receptor
Methyl substitution in histamine homologs offers a way to shift the selectivity in favor of the H4R.
But carriers of one or three copies of HRH1 (show DHX8 Proteins) (5% of individuals), HRH2 (show DHX15 Proteins) (1.1%) and HRH4 genes (0.9%) were also identified.
Data show down-regulation of cyclic adenosine monophosphate (cAMP) was the secondary signalling after H4 receptor activation, which in turn resulting in inactivation of transforming growth factor-beta1(TGF-beta1 (show TGFB1 Proteins)) pathway.
These results indicate a proinflammatory role of histamine via H4R in inflammatory bowel disease.
The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis.
H4R expression on murine keratinocytes was detected after stimulation with LPS (show TLR4 Proteins) and peptidoglycan.
the present study shows that H4 receptors potentially play a role in IgE induced FcepsilonRI (show FCER1A Proteins) upregulation
Acting via its H4 receptors, histamine impedes lipopolysaccharide-induced microglia migration and interleukin (IL)-1beta (show IL1B Proteins) release under inflammatory challenge.
development of allergic rhinitis proceeded in two distinct stages: histamine release from FcepsilonRI (show FCER1A Proteins)-activated mast cells, followed by histamine-mediated recruitment of H(4)R-expressing basophils to the nasal cavity and activation through FcepsilonRI (show FCER1A Proteins).
The majority of hypertrophic ATDC5 chondrocytes express H4R, suggesting that this receptor is associated with the differentiation of chondrocytes into hypertrophic cells.
Histamine Hrh4-deficient mice, despite having equivalent T effector cell responses, develop more severe allergic encephalomyelitis, augmented neuroinflammation, and increased blood-brain barrier permeability compared with wild-type mice.
enhances LPS (show TLR4 Proteins)-induced IL-6 (show IL6 Proteins) production in mast cells
Therapeutic H4R antagonism can significantly ameliorate allergen induced, Th2 cytokine driven pathologies such as lung remodeling and airway dysfunction in asthma.
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene.
histamine H4 receptor
, histamine receptor H4
, histamine 4 receptor
, histamine H4 receptor-like
, G-protein coupled receptor 105