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Histamine Receptor H4 Proteins (HRH4)

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Additionally we are shipping Histamine Receptor H4 Antibodies (72) and Histamine Receptor H4 Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HRH4 59340 Q9H3N8
Rat HRH4 HRH4 170704 Q91ZY1
HRH4 225192 Q91ZY2
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Top Histamine Receptor H4 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$246.96
Details

HRH4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Histamine Receptor H4 (HRH4) Interaction Partners

Guinea Pig Histamine Receptor H4 (HRH4) interaction partners

Human Histamine Receptor H4 (HRH4) interaction partners

  1. Activation of the H4R could induce phosphorylation of ERK (show EPHB2 Proteins).

  2. Suggest roles for HRH4 polymorphisms and ankylosing spondylitis susceptibility.

  3. Molecular modelling studies, including molecular dynamic simulations and calculation of Gibbs energy of solvation of hH3R (show HRH3 Proteins) and hH4R, were studied.

  4. HRH4 was increased in clinically-isolated syndrome and different stages of multiple sclerosis compared to health control.

  5. No evidence was found for the presence of histamine H4 receptor in monocytes.

  6. In neutrophils, the H4 receptor may block signals emanating from Mac-1 (show ITGAM Proteins)-controlling degranulation. Engagement of the H4 receptor by selective agonists blocked Mac-1 (show ITGAM Proteins)-dependent activation of p38 MAPK (show MAPK14 Proteins).

  7. The activation of H4R in human mast cells produced not only inflammatory mediators that are associated with allergic reactions but also other inflammatory conditions.

  8. Histamine through the histamine H4 receptor exhibits a crucial role in breast tumour progression.

  9. Obtained results allow for statement that developed cellular model may be successfully employed in search for new compounds active at histamine H4 receptor

  10. Methyl substitution in histamine homologs offers a way to shift the selectivity in favor of the H4R.

Mouse (Murine) Histamine Receptor H4 (HRH4) interaction partners

  1. Histamine H4 receptor knockout mice display reduced inflammation in a chronic model of atopic dermatitis

  2. These results indicate a proinflammatory role of histamine via H4R in inflammatory bowel disease.

  3. The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis.

  4. H4R expression on murine keratinocytes was detected after stimulation with LPS (show TLR4 Proteins) and peptidoglycan.

  5. the present study shows that H4 receptors potentially play a role in IgE induced FcepsilonRI (show FCER1A Proteins) upregulation

  6. Acting via its H4 receptors, histamine impedes lipopolysaccharide-induced microglia migration and interleukin (IL)-1beta (show IL1B Proteins) release under inflammatory challenge.

  7. development of allergic rhinitis proceeded in two distinct stages: histamine release from FcepsilonRI (show FCER1A Proteins)-activated mast cells, followed by histamine-mediated recruitment of H(4)R-expressing basophils to the nasal cavity and activation through FcepsilonRI (show FCER1A Proteins).

  8. The majority of hypertrophic ATDC5 chondrocytes express H4R, suggesting that this receptor is associated with the differentiation of chondrocytes into hypertrophic cells.

  9. Histamine Hrh4-deficient mice, despite having equivalent T effector cell responses, develop more severe allergic encephalomyelitis, augmented neuroinflammation, and increased blood-brain barrier permeability compared with wild-type mice.

  10. enhances LPS (show TLR4 Proteins)-induced IL-6 (show IL6 Proteins) production in mast cells

Histamine Receptor H4 (HRH4) Protein Profile

Protein Summary

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Histamine Receptor H4 Proteins (HRH4)

  • histamine receptor H4 (HRH4)
  • histamine H4 receptor (LOC100358525)
  • histamine receptor H4 (Hrh4)
  • AXOR35 protein
  • BG26 protein
  • GPCR105 protein
  • GPRv53 protein
  • H4 protein
  • H4R protein
  • HH4R protein
  • HRH4 protein

Protein level used designations for Histamine Receptor H4 Proteins (HRH4)

histamine H4 receptor , histamine receptor H4 , histamine 4 receptor , histamine H4 receptor-like , G-protein coupled receptor 105 , SP9144 , pfi-013 , H4R , HH4R

GENE ID SPECIES
397224 Sus scrofa
468501 Pan troglodytes
490512 Canis lupus familiaris
702044 Macaca mulatta
769106 Gallus gallus
783312 Bos taurus
783354 Bos taurus
100034111 Equus caballus
100358525 Oryctolagus cuniculus
100379272 Cavia porcellus
100442858 Pongo abelii
59340 Homo sapiens
170704 Rattus norvegicus
225192 Mus musculus
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