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HDC encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Additionally we are shipping Histidine Decarboxylase Antibodies (56) and Histidine Decarboxylase Kits (9) and many more products for this protein.
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genes encoding for proteins involved in histamine signaling [histidine decarboxylase (hdc), histamine-gated chloride channel (show CLCA1 Proteins) subunit 1 (hisCl1), ora transientless (ort)] cause abnormal temperature preferences
Ethanol upregulates histidine decarboxylase expression in neural brain networks.
Lack of endogenous histamine in NOD HDC(-/-) mice decreased the incidence of diabetes in relation to their wild-type counterpart.
the structure and function of the retina in mice that lacked expression of the rate limiting enzyme in the formation of histamine, histidine decarboxylase (Hdc-/- mouse), were investigated.
SDS (show SDS Proteins) induces itch through increased production of epidermal histamine, which results from an increase in the gene expression and post-translation processing of L-histidine decarboxylase.
HDC, whose expression is remarkably downregulated during the first few days after birth in dermal cells of mice, plays essential roles in the hair-inducing ability of newborn mouse dermal cells
An increased expression of H3 receptors in HDC KO mice without any changes in the spontaneous firing of "histaminergic" neurons without histamine and their responses to the H3 receptor agonist (R)-alpha-methylhistamine.
Histidine decarboxylase was found at comparably high levels in mouse striatum.
There was no difference in the levels of vascular endothelial growth factor between HDC-/- or wild-type mice, either in the lung or in bronchoalveolar-lavage cells.
HDC-/- mice showed reduced severity of K/BxN serum-induced arthritis.
in 12 day old embryonic stem cells histidine decarboxylase was confined to peripheral cells and small clusters of cells, inner cells were usually negative for it
Metabolic phenotype of mice lacking histamine due to targeted disruption of histidine decarboxylase. Characterized by visceral adiposity, increased of brown adipose tissue, impaired glucose tolerance, hyperinsulinemia, and hyperleptinemia.
Human enterochromaffin-like cells appear to partially co-express VMAT-2 (show Slc18a2 Proteins) and HDC. Co-expression of VMAT-2 (show Slc18a2 Proteins) and HDC might be required for increased histamine production in patients with gastric neuroendocrine tumors.
The findings indicate that polymorphisms of HDC gene were significantly associated with breast cancer in Chinese Han population and may be novel diagnostic or therapeutic targets for breast cancer.
HDC rs17740607 polymorphism is at least a partial loss-of-function variant and acts as a protective factor against chronic heart failure
Investigated variation across the HDC (histidine decarboxylase) gene for association with Tourette Syndrome.
HDC production in the stomach is associated with bile acid exposure and its related transcriptional regulation network of FXR (show NR1H4 Proteins), SHP (show LAMC1 Proteins), and CDX1 (show CDX1 Proteins).
Data indicate that histidine decarboxylase (HDC) is expressed by neutrophils.
Structural study reveals that Ser (show SIGLEC1 Proteins)-354 determines substrate specificity on human histidine decarboxylase.
crystal of histidine decarboxylase belonged to space group C2, with unit-cell parameters a = 215.16, b = 112.72, c = 171.39 A, beta = 110.3 degrees
It was shown that for serum and urine, HDC levels achieved sensitivities and specificities compatible to or even greater than those of established biomarkers for the diagnosis of intestinal mucosal injury in patients with acute intestinal obstruction.
The novel concept that an autocrine loop, consisting of enhanced histamine synthesis by histidine decarboxylase, sustains cholangiocarcinoma growth is proposed.
This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.
, histidine decarboxylase
, histidine decarboxylase-like
, headcase protein homolog
, L-histidine decarboxylase