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The protein encoded by HINT1 can hydrolyze substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. Additionally we are shipping HINT1 Proteins (17) and HINT1 Kits (1) and many more products for this protein.
Showing 10 out of 61 products:
Human Polyclonal HINT1 Primary Antibody for EIA, IF - ABIN499948
Wang, Zhang, Li, Xu, Santella, Weinstein: Hint1 inhibits growth and activator protein-1 activity in human colon cancer cells. in Cancer research 2007
Show all 5 references for ABIN499948
Human Polyclonal HINT1 Primary Antibody for ELISA, WB - ABIN516451
Rodríguez-Muñoz, Sánchez-Blázquez, Vicente-Sánchez, Bailón, Martín-Aznar, Garzón: The histidine triad nucleotide-binding protein 1 supports mu-opioid receptor-glutamate NMDA receptor cross-regulation. in Cellular and molecular life sciences : CMLS 2011
Show all 2 references for ABIN516451
Chicken Polyclonal HINT1 Primary Antibody for IHC, WB - ABIN2785873
Chou, Sham, Wagner: Impact of the C-terminal loop of histidine triad nucleotide binding protein1 (Hint1) on substrate specificity. in Biochemistry 2007
Human Polyclonal HINT1 Primary Antibody for IF, ELISA - ABIN1533751
Brzoska, Chen, Levin, Kuo, Collins, Fu, Gray, Christman: Cloning, mapping, and in vivo localization of a human member of the PKCI-1 protein family (PRKCNH1). in Genomics 1997
Underexpression of Hint1 is associated with invasion of hepatocellular carcinoma.
first structure (at a 2.34A resolution) of a complex of human HINT1 with a non-hydrolyzable analog of an Ap4A dinucleotide
Absence of HINT1 mutations in a UK and Spanish cohort of patients with inherited neuropathies
In hepatocellular carcinoma, HINT1 is a regulator of IkappaBalpha (show NFKBIA Antibodies) through SCF (show KITLG Antibodies)(beta-TrCP (show BTRC Antibodies)) E3 ligase.
HINT1 mutations seem to be one of the most frequent causes of inherited neuropathy and are probably the most frequent cause of HMN in Czech patients. We suggest all HMN/CMT2 patients be tested for the presence of the prevalent mutation, the p.R37P
The teneurin-1 intracellular domain binds HINT1, thus switching on MITF-dependent transcription of GPNMB.
Data suggest that histidine triad nucleotide binding protein 1 (HINT1) should be added to the list of genes to check for in distal hereditary motor neuropathies (dHMNs).
Study gives suggestive evidence that HINT1 rs3852209 may be related to smoking status in Chinese men.
BTF3 (show BTF3 Antibodies), HINT1, NDRG1 (show NDRG1 Antibodies) and ODC1 (show ODC1 Antibodies) protein over-expression in human prostate cancer tissue
Histidine triad nucleotide-binding protein 1, bifunctional aminoacyl-tRNA synthetase (show EPRS Antibodies), and clusterin (show CLU Antibodies) precursor protein may serve as potential biomarkers distinguishing type 2 diabetes mellitus patients from healthy controls.
It was observed that HINT1 protein binds to GPCRs and NMDAR NR1 (show GRIN1 Antibodies) subunits in a calcium-independent manner, whereas sigma1R (show SIGMAR1 Antibodies) binding to these proteins increases in the presence of calcium.
Results suggest that Hint1 deficiency leads to an increased protein level of PKC gamma (show PRKCG Antibodies) in the brain and a compromised activation response of PKC gamma (show PRKCG Antibodies) upon stimulation
HINT1 is involved in the behavioral abnormalities induced by social isolation and exerts distinct roles in different encephalic regions.
These results further support a role for HINT1 in nicotine-mediated behaviors and suggest that alterations in the gene may have differential effects on phenotype in males and females.
Activated mu-opioid receptors stimulate the production of nitric oxide (NO), and the redox zinc switch RGSZ2 (show RGS17 Antibodies) converts this signal into free zinc ions that are required to recruit the redox sensor PKCgamma (show PRKCG Antibodies) to HINT1 proteins.
lipidomic phenotype of the Hint1(-/-) mouse
these mice do not provide a disease model or a means for investigating the basis of HINT1-associated neuropathy and neuromyotonia
Cannabinoids that act through CNR1 (show CNR1 Antibodies) maintain the negative control of HINT1 on NMDAR (show GRIN1 Antibodies) function and their protection against glutamate (show GRIN1 Antibodies) excitotoxic insult persists.
our data support a role for the HINT1 gene in mediating behaviors associated with nicotine reward and physical nicotine withdrawal, and provide insight into the role of HINT1 in nicotine dependence-like behaviors.
Thus the study demonstrates a novel function of HINT1 that involves the regulation of store-operated channel-mediated Ca(2 (show CA2 Antibodies)+) entry pathway
structure of the rabbit HINT1-adenosine complex is reported at 1.10 A resolution, which is one of the highest resolutions obtained for a HINT1 structure
The protein encoded by this gene can hydrolyze substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif, which is part of the loop that binds to the substrate. This gene has been found to be a tumor suppressing gene. Several transcript variants, but only one of them protein-coding, have been found for this gene.
histidine triad nucleotide binding protein 1
, PKCI-Z-related protein
, adenosine 5'-monophosphoramidase
, histidine triad nucleotide-binding protein 1
, protein kinase C inhibitor 1
, protein kinase C-interacting protein 1
, PKC inhibitor/ interacting protein
, 17 kDa inhibitor of protein kinase C
, protein kinase C, iota
, histidine triad missing Z
, protein kinase C inhibitor