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Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.
Showing 3 out of 3 products:
Fruit Fly (Drosophila melanogaster) Polyclonal HIS2AV Primary Antibody for ELISA, WB - ABIN964669
Na, Park, Pyo, Lee, Jeon, Kim, Yoo: Mechanism of metformin: Inhibition of DNA damage and proliferative activity in Drosophila midgut stem cell. in Mechanisms of ageing and development 2013
Show all 2 references for ABIN964669
Fruit Fly (Drosophila melanogaster) Polyclonal HIS2AV Primary Antibody for ELISA, WB - ABIN129671
Shaukat, Liu, Choo, Hussain, OKeefe, Richards, Saint, Gregory: Chromosomal instability causes sensitivity to metabolic stress. in Oncogene 2014
Show all 2 references for ABIN129671
The study reports the crystal structure of the H2A.Z-binding domain of Drosophila melanogaster YL1 (dYL1-Z) in complex with an H2A.Z-H2B dimer at 1.9-A resolution.
The Drosophila histone variant H2A.V works in concert with HP1 (show CBX5 Antibodies) to promote kinetochore-driven microtubule formation.
nucleosomes present significant, context-specific barriers to RNAPII in vivo that can be tuned by the incorporation of H2A.Z (show H2AFZ Antibodies)
chromatin loosening and associated initiation of gene expression is activated by phosphorylation of H2Av (show H2AFV Antibodies) in a nucleosome positioned in promoter regions of PARP-1 (show PARP1 Antibodies)-dependent genes
Unlike other organisms that employ several H2A variants for different functions, the parsimonious fruit fly Drosophila melanogaster gets along with just a single H2A variant, H2A.V. Remarkably, H2A.V unites within one molecule features and functions of two different mammalian H2A variants, H2A.Z (show H2AFZ Antibodies) and H2A.X (show H2AFX Antibodies). [Review]
H2A.Z (show H2AFZ Antibodies) nucleosome occupancy has no effect on sequence variability of Drosophila genome
PARP1 (show PARP1 Antibodies) is targeted to chromatin by association with the histone H2A variant (H2Av).
demonstrated that the dTip60 (show KAT5 Antibodies) chromatin-remodeling complex acetylates nucleosomal phospho-H2Av (show H2AFV Antibodies) and exchanges it with an unmodified H2Av (show H2AFV Antibodies); both the histone acetyltransferase (show HAT Antibodies) dTip60 (show KAT5 Antibodies) and the atpase (show DNAH8 Antibodies) Domino/p400 (show EP400 Antibodies) catalyze the exchange of phospho-H2Av (show H2AFV Antibodies)
In Rsf-1 (show RSF1 Antibodies) mutant, the levels of histone H3K9 dimethylation and histone H2A variant H2Av were significantly reduced in an euchromatic region juxtaposed with heterochromatin.
in the absence of H2A.Z (show H2AFZ Antibodies), checkpoint-defective telomeres adopt alternative structures, which are permissive for the loading of the capping machinery at Drosophila telomeres.
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Acts as a Polycomb group (PcG) protein required to maintain the transcriptionally repressive state of homeotic genes of the animal throughout development. Required for histone H3 'Lys-9' methylation and histone H4 'Lys-12' acetylation, two modifications that are essential for heterochromatin formation. Also involved in DNA double strand break (DSB) repair. Essential for early development.
, H2A variant
, histone 2A variant
, histone H2A variant
, histone H2Av
, histone variant H2Av