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anti-Histone H2A Variant (HIS2AV) Antibodies

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

list all antibodies Gene Name GeneID UniProt
HIS2AV 43229 P08985
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Top anti-Histone H2A Variant Antibodies at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Fruit Fly Rabbit Un-conjugated ELISA, WB Western blot using affinity purified anti-histone H2AvD pS137 antibody shows detection of a band at ~15 kDa corresponding to phosphorylated H2AvD (lane 2 arrow-head). Lanes contain either mock-irradiated (lane 1) or 4000-RAD gamma irradiated (lane 2) Drosophila melanogaster (3rd instar) larvae brain WC lysate separated on by SDS-PAGE and transferred to nitrocellulose. After blocking the membrane was probed with the primary antibody diluted to 1:500. Washes and reaction with secondary antibody followed incubation. Use HRP conjugated Gt-a-Rabbit IgG [H&L] MX (611-103-122) and ECL for detection. 25 μL Log in to see 2 to 3 Days
$135.00
Details
Fruit Fly Rabbit Un-conjugated ELISA, WB Western blot using affinity purified anti-histone H2AvD pS137 antibody shows detection of a band at ~15 kDa corresponding to phosphorylated H2AvD (lane 2 arrow-head). Lanes contain either mock-irradiated (lane 1) or 4000-RAD gamma irradiated (lane 2) Drosophila melanogaster (3rd instar) larvae brain WC lysate separated on by SDS-PAGE and transferred to nitrocellulose. After blocking the membrane was probed with the primary antibody diluted to 1:500. Washes and reaction with secondary antibody followed incubation. Use HRP conjugated Gt-a-Rabbit IgG [H&L] MX (611-103-122) and ECL for detection. 100 μg Log in to see 2 to 3 Days
$369.00
Details
Fruit Fly Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 8 to 10 Days
$610.50
Details

HIS2AV Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Fruit Fly (Drosophila melanogaster)


Top referenced anti-Histone H2A Variant Antibodies

  1. Fruit Fly (Drosophila melanogaster) Polyclonal HIS2AV Primary Antibody for ELISA, WB - ABIN964669 : Na, Park, Pyo, Lee, Jeon, Kim, Yoo: Mechanism of metformin: Inhibition of DNA damage and proliferative activity in Drosophila midgut stem cell. in Mechanisms of ageing and development 2013 (PubMed)
    Show all 2 references for ABIN964669

  2. Fruit Fly (Drosophila melanogaster) Polyclonal HIS2AV Primary Antibody for ELISA, WB - ABIN129671 : Shaukat, Liu, Choo, Hussain, OKeefe, Richards, Saint, Gregory: Chromosomal instability causes sensitivity to metabolic stress. in Oncogene 2014 (PubMed)
    Show all 2 references for ABIN129671

More Antibodies against Histone H2A Variant Interaction Partners

Fruit Fly (Drosophila melanogaster) Histone H2A Variant (HIS2AV) interaction partners

  1. The study reports the crystal structure of the H2A.Z-binding domain of Drosophila melanogaster YL1 (dYL1-Z) in complex with an H2A.Z-H2B dimer at 1.9-A resolution.

  2. The Drosophila histone variant H2A.V works in concert with HP1 (show CBX5 Antibodies) to promote kinetochore-driven microtubule formation.

  3. nucleosomes present significant, context-specific barriers to RNAPII in vivo that can be tuned by the incorporation of H2A.Z (show H2AFZ Antibodies)

  4. chromatin loosening and associated initiation of gene expression is activated by phosphorylation of H2Av (show H2AFV Antibodies) in a nucleosome positioned in promoter regions of PARP-1 (show PARP1 Antibodies)-dependent genes

  5. Unlike other organisms that employ several H2A variants for different functions, the parsimonious fruit fly Drosophila melanogaster gets along with just a single H2A variant, H2A.V. Remarkably, H2A.V unites within one molecule features and functions of two different mammalian H2A variants, H2A.Z (show H2AFZ Antibodies) and H2A.X (show H2AFX Antibodies). [Review]

  6. H2A.Z (show H2AFZ Antibodies) nucleosome occupancy has no effect on sequence variability of Drosophila genome

  7. PARP1 (show PARP1 Antibodies) is targeted to chromatin by association with the histone H2A variant (H2Av).

  8. demonstrated that the dTip60 (show KAT5 Antibodies) chromatin-remodeling complex acetylates nucleosomal phospho-H2Av (show H2AFV Antibodies) and exchanges it with an unmodified H2Av (show H2AFV Antibodies); both the histone acetyltransferase (show HAT Antibodies) dTip60 (show KAT5 Antibodies) and the atpase (show DNAH8 Antibodies) Domino/p400 (show EP400 Antibodies) catalyze the exchange of phospho-H2Av (show H2AFV Antibodies)

  9. In Rsf-1 (show RSF1 Antibodies) mutant, the levels of histone H3K9 dimethylation and histone H2A variant H2Av were significantly reduced in an euchromatic region juxtaposed with heterochromatin.

  10. in the absence of H2A.Z (show H2AFZ Antibodies), checkpoint-defective telomeres adopt alternative structures, which are permissive for the loading of the capping machinery at Drosophila telomeres.

Histone H2A Variant (HIS2AV) Antigen Profile

Protein Summary

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Acts as a Polycomb group (PcG) protein required to maintain the transcriptionally repressive state of homeotic genes of the animal throughout development. Required for histone H3 'Lys-9' methylation and histone H4 'Lys-12' acetylation, two modifications that are essential for heterochromatin formation. Also involved in DNA double strand break (DSB) repair. Essential for early development.

Gene names and symbols associated with HIS2AV

  • Histone H2A variant (His2Av) antibody
  • 5499 antibody
  • CG5499 antibody
  • Dmel\\CG5499 antibody
  • gamma-H2Av antibody
  • gamma-His2Av antibody
  • gammaH2Av antibody
  • H2A antibody
  • H2A.F/Z antibody
  • H2a.V antibody
  • H2A.X antibody
  • H2A.Z antibody
  • H2av antibody
  • h2AvD antibody
  • H2AV_DROM antibody
  • H2AX antibody
  • H2AZ antibody
  • his antibody
  • His2 antibody
  • His2AV antibody
  • His2AvD antibody
  • HisH2Av antibody
  • Hist antibody
  • Hist2av antibody
  • l(3)05146 antibody
  • l(3)97Dd antibody
  • l(3)810 antibody
  • l(3)L1602 antibody

Protein level used designations for HIS2AV

CG5499-PA , CG5499-PB , H2A variant , His2Av-PA , His2Av-PB , Histone-2A , Histone2Av , histone , histone 2A variant , histone H2A variant , histone H2Av , histone variant H2Av , histone2A , histone2AvD

GENE ID SPECIES
43229 Drosophila melanogaster
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