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In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Additionally we are shipping HOXA5 Antibodies (116) and many more products for this protein.
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Downregulation of HOXA5 by shRNA may trigger apoptosis and overcome drug resistance in leukemia cells.
HOXA5-induced apoptosis was p53 (show TP53 Proteins)-independent.
Among the mechanosensitive genes, the two transcription factors, HoxA5 and Klf3 (show KLF3 Proteins), contain cAMP-response-elements methylation of which could serve as a mechanosensitive master switch in gene expression in atherosclerosis. (Review)
In colon cancer, HOXA5 is downregulated, and its re-expression induces loss of the cancer stem cell phenotype, preventing tumor progression and metastasis.
Ectopic expression of HOXA5 in highly invasive cancer cells suppressed cell migration, invasion, and filopodia formation in vitro and inhibited metastatic potential in vivo.
The NK AML (show RUNX1 Proteins) patients with NPM1 (show NPM1 Proteins) mutations exhibited elevated HOXA4 (show HOXA4 Proteins) methylation and expression levels of HOXA5 and MEIS1 (show MEIS1 Proteins) compared with the NPM1 (show NPM1 Proteins) wildtype patients.
Increased expression of HOXA5 is associated with acute myeloid leukemia (show BCL11A Proteins).
Our findings present that decreased HOXA5 could be identified as a poor prognostic biomarker in nonsmall cell lung cancer and regulate cell proliferation and invasion
miR (show MLXIP Proteins)-1271 regulates non-small-cell lung cancer cell proliferation and invasion, via the down-regulation of HOXA5.
Our analysis showed that miR (show MLXIP Proteins)-196a suppressed the expression of HOXA5 both at the mRNA and protein levels; knockdown of HOXA5 expression in A549 cells using RNAi was shown to promote NSCLC cell proliferation, migration and invasion.
HoxA5 represents a novel molecule for restricting pathological and tumorigenic angiogenesis.
Enforced expression of Hoxa5 in haematopoietic stem cells leads to aberrant erythropoiesis in vivo.
YY1 (show YY1 Proteins) acts as a transcriptional activator of Hoxa5 gene expression in mouse organogenesis.
Hoxa5 and Hoxb5 (show HOXB5 Proteins) paralog genes share some functions during lung morphogenesis; Hoxa5 plays a predominant role.
Two Hox (show MSH2 Proteins) genes, Hoxa5 and Hoxc5 (show HOXC5 Proteins), control diverse aspects of phrenic motor column development.
Hoxa5, a stroma-specific gene, plays a significant role in ovarian biology and may be involved in ovarian cancer predisposition
Hoxa5 larger transcripts may participate in the control of Hox (show MSH2 Proteins) gene expression.
Hoxa5 and p53 (show TP53 Proteins) cooperate in mammary tumorigenesis in vivo.
findings provide insight into the molecular controls of patterning events of the stomach, supporting the notion that Hoxa5 acts in regionalization and specification of the stomach by setting up the proper domains of expression of signaling molecules
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis.
, homeo box A5
, similar to Homeobox protein Hox-A5 (Hox-1.3) (M2)
, hoxa5a protein
, homeobox protein Hox-1.3
, homeobox protein Hox-A5
, homeo box 1C
, homeobox protein HOXA5
, homeobox protein Hox-1C
, homeobox protein M2
, Homeobox protein Hox-A5