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HOXC4 belongs to the homeobox family of genes. Additionally we are shipping Homeobox C4 Antibodies (82) and Homeobox C4 Kits (1) and many more products for this protein.
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HOXC4 homeoprotein expands human hematopoietic immature cells by 3 to 6 times ex vivo and significantly improves the level of in vivo engraftment.
Human cytomegalovirus downregulates while all-trans retinoic acid upregulates expression of hoxc4 and hoxc6 (show HOXC6 Proteins) in lymphocytic progenitor cells.
Esr1 (show ESR1 Proteins) bind to and activate the HOXC4 promoter to potentiate HoxC4-mediated AID induction, immunoglobulin class switch and somatic hypermutation.
Selective inhibition of class switching to IgG and IgE by recruitment of this and Oct-1 (show POU2F1 Proteins) proteins and Ku70 (show XRCC6 Proteins)/Ku86 (show XRCC5 Proteins) to newly identified ATTT cis (show CISH Proteins)-elements.
The hs1,2mediated enhancement of V(H) and C(H) promoter-driven transcription as induced by HoxC4 and Oct-1/Oct-2 suggests an important role of these homeodomain proteins in the overall regulation of the IgH locus expression.
The HOXC4 expression was clearly detected in all inv (show INVS Proteins)(7) positive patients.
HoxC4 directly activates the Aicda (show AICDA Proteins) promoter
In presence of these inducing agents, lipid accumulation as well as expression of HoxA1 (show HOXA1 Proteins), HoxA5 (show HOXA5 Proteins), HoxC4 &HoxC8 (show HOXC8 Proteins) markedly enhanced. Irrespective of presence or absence of T3, insulin (show INS Proteins) down regulates HoxA10 (show HOXA10 Proteins). T3 results in over expression of HoxA5 (show HOXA5 Proteins), HoxC4 and HoxC8 (show HOXC8 Proteins) genes, whereas insulin (show INS Proteins) up regulates expression of only HoxC8 (show HOXC8 Proteins)
NF-kappaB (show NFKB1 Proteins) mediates APRIL-induced HoxC4 transcription.
These findings suggest that in lupus B cells, upregulation of HoxC4 plays a major role in dysregulation of AID expression.
Quantitative RNA analysis for the genes flanking the breakpoint indicated no changes in expression levels except for some homeobox (show PRRX1 Proteins) C (Hoxc) genes whose expression was elevated in developing and mature skin of the ears but not of other body regions.
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons.
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