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The protein encoded by HIPK1 belongs to the Ser/Thr family of protein kinases and HIPK subfamily. Additionally we are shipping HIPK1 Antibodies (60) and many more products for this protein.
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Analysis of these mutants revealed that HIPK1, HIPK2 (show HIPK2 Proteins) and HIPK3 (show HIPK3 Proteins) but not HIPK4 (show HIPK4 Proteins) are capable of autophosphorylating on other tyrosines
PAGE4 (show PAGE4 Proteins), a regulator of c-Jun (show JUN Proteins) transactivation, is phosphorylated by homeodomain-interacting protein kinase 1.
HIPK1 drives p53 (show TP53 Proteins) activation to limit colorectal cancer cell growth.
HIPK1 and HIPK2 (show HIPK2 Proteins), are transcriptional corepressors that regulate TGF-beta (show TGFB1 Proteins)-dependent angiogenesis during embryonic development.
HIPK1 expression was identified only in invasive breast cancer cells with three different patterns: cytoplasmic, nuclear, and both cytoplasmic and nuclear.
These findings indicate that the control of HIPK1 stability by Mdm2 (show MDM2 Proteins)-NORE1 (show RASSF5 Proteins) has a major effect on cell behaviour, and epigenetic inactivation of NORE1 (show RASSF5 Proteins) enables adenocarcinoma formation in vivo through HIPK1 stabilization.
TNFalpha (show TNF Proteins)-induced desumoylation and cytoplasmic translocation of HIPK1 are critical in TNFalpha (show TNF Proteins)-induced ASK1 (show MAP3K5 Proteins)-JNK (show MAPK8 Proteins)/p38 (show CRK Proteins) activation
c-Myb (show MYB Proteins) appears to be phosphorylated by HIPK1 in its negative regulatory domain as supported by both in vivo and in vitro data.
Therefore, our data confirm that the beta-Catenin (show CTNNB1 Proteins) signaling plays a dual role in controlling cell proliferation/differentiation in the brain and indicate that Hipk1 is the crucial interactor able to revert the outcome of beta-Catenin (show CTNNB1 Proteins) signaling in cells.
Despite the expanded marginal zone B cell population in the HIPK1(-/-) mice, the T-independent type 2 humoral response was impaired.
HIPK1 and Daxx (show DAXX Proteins) collaborate in regulating transcription.
characterization of cells and gene-targeted mice deficient for the p53 (show TP53 Proteins)-binding kinase homeodomain-interacting protein kinase 1
The present study indicated the overlapping roles for Hipk1 and Hipk2 (show HIPK2 Proteins) in mediating cell proliferation and apoptosis in response to morphogenetic and genotoxic signals during mouse development.
SENP1 (show SENP1 Proteins) mediates TNF (show TNF Proteins)-induced desumoylation and translocation of HIPK1, leading to an enhanced ASK1 (show MAP3K5 Proteins)-dependent apoptosis.
TNFalpha (show TNF Proteins)-induced desumoylation and cytoplasmic translocation of HIPK1 are critical in TNFalpha (show TNF Proteins)-induced ASK1 (show MAP3K5 Proteins)-JNK (show MAPK8 Proteins)/p38 (show MAPK14 Proteins) activation
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.
homeodomain interacting protein kinase 1
, homeodomain-interacting protein kinase 1-like
, homeodomain-interacting protein kinase 1
, homeodomain interacting protein kinase 1-like protein
, nuclear body associated kinase 2b
, nuclear body-associated kinase 2
, protein kinase Myak