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HCFC1 is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. Additionally we are shipping HCFC1 Antibodies (34) and HCFC1 Kits (2) and many more products for this protein.
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survival of the heterozygous Hcfc1(epiKO/+) female embryos llustrates the developmental plasticity of the post-implantation mouse embryo - in this instance, permitting survival of females heterozygous for an X-linked embryonic lethal allele
our work identifies plausible cellular consequences of missense HCFC1 variants and identifies likely and relevant disease mechanisms that converge on embryonic stages of brain development.
These results indicate that HCF-1 represents a novel transcriptional regulator required for maintaining pancreatic b-cell function.
Ronin/Hcf-1 controls a genetic program that contributes to the unimpeded growth of embryonic stem cells.
HCF-1 is an important component of the viral latency-reactivation cycle and it is regulated by association with a component that is distinct from the identified HCF-1 interaction factors
Bap1 (show BAP1 Proteins) helps to control cell proliferation by regulating HCF-1 protein levels and by associating with genes involved in the G(1)-S transition
O-GlcNAcylation of the transcription regulators Host Cell Factor-1 (HCF-1) and Ten-Eleven Translocation protein 2 (TET2) could be readily observed. Our study raises questions on the occurrence and abundance of O-GlcNAcylation as a histone modification
These results demonstrate that distinct OGT (show OGT Proteins)-binding sites in HCF-1 promote proteolysis, and provide novel insights into the mechanism of this unusual protease activity.
We report here two brothers with dysmorphic features and complex malformations resulting from an X-linked inherited cobalamin deficiency due to HCFC1 gene mutation.
THAP11, ZNF143 (show ZNF143 Proteins), and HCF-1 form a mutually dependent complex on chromatin, which is independent of E2F (show E2F1 Proteins) occupancy.
study reports the tetratricopeptide-repeat domain of O-GlcNAc (show OGT Proteins) transferase binds the carboxyl-terminal portion of an HCF-1 proteolytic repeat such that the cleavage region lies in the glycosyltransferase (show GTDC2 Proteins) active site above uridine diphosphate-GlcNAc; protein glycosylation and HCF-1 cleavage occur in the same active site
A missense mutation in a global transcriptional coregulator, HCFC1, was identified as the genetic basis of an X-linked form of combined methylmalonic acidemia and hyperhomocysteinemia.
HCFC1 is a common component of active human CpG-island promoters and coincides with ZNF143 (show ZNF143 Proteins), THAP11, YY1 (show YY1 Proteins), and GABP transcription factor occupancy.
MLL5 can associate with HCF-1 and then be recruited to E2F1 (show E2F1 Proteins)-responsive promoters to stimulate H3K4 trimethylation and transcriptional activation.
A noncoding, regulatory mutation was identified in the binding site of transcription factor YY1 (show YY1 Proteins) in the HCFC1 gene in patients with nonsyndromic intellectual disability.
HCFC1 plays a role in craniofacial development, which is in part mediated through the regulation of MMACHC (show MMACHC Proteins) expression
This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.
, VP16 accessory protein
, VP16-accessory protein
, host cell factor 1
, host cell factor C1