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Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM, Jul 2010].. Additionally we are shipping HCN2 Kits (7) and HCN2 Proteins (6) and many more products for this protein.
Showing 10 out of 71 products:
Human Polyclonal HCN2 Primary Antibody for ELISA, WB - ABIN1535195
Grimwood, Gordon, Olsen, Terry, Schmutz, Lamerdin, Hellsten, Goodstein, Couronne, Tran-Gyamfi, Aerts, Altherr, Ashworth, Bajorek, Black, Branscomb, Caenepeel, Carrano, Caoile, Chan, Christensen et al.: The DNA sequence and biology of human chromosome 19. ... in Nature 2004
Human Monoclonal HCN2 Primary Antibody for AA, ICC - ABIN361764
Zong, Eckert, Yuan, Wahl-Schott, Abicht, Fang, Li, Mistrik, Gerstner, Much, Baumann, Michalakis, Zeng, Chen, Biel: A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase. in The Journal of biological chemistry 2005
HCN2 has a role in maturation and processing of the amyloid precursor protein (show APP Antibodies)
promoter methylation status does not appear to be a major determinant of HCN2 expression in normal and adenoid cystic carcinoma ( ACC )tissues. HCN2 hypomethylation is a biomarker of ACC and may play an important role in the carcinogenesis of ACC.
Aged patients with sinus rhythm exhibited significantly higher expression levels of HCN2 and HCN4 channel mRNA and protein (P<0.05), but significantly lower expression levels of miR1 and 133, compared with those of adult patients with sinus rhythm.
Data show that Rab8b (show RAB8B Antibodies)-interacting protein TRIP8b (show PEX5L Antibodies) does not compete with cyclic AMP (show APRT Antibodies) for the same binding region of hyperpolarization activated cyclic nucleotide gated potassium channel 2 (HCN2).
N-glycosylation is not required for HCN2 channels to function.
Thermal hyperalgesia under chronic inflammatory conditions is mediated by HCN2 channels.
Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner.
HCN2 polymorphism may play a role in chronic inflammatory periodontitis but not in peri (show PLIN1 Antibodies)-implantitis.
LBB-injected HCN2/SkM1 (show SCN4A Antibodies) potentially provides a more clinically suitable biological pacemaker strategy than other reported constructs. This superiority is attributable to the more negative AP threshold and injection into the LBB
HCN2 channels make an important contribution to the maintenance of spontaneous burst activity in embryonic cortical neuron cultures.
Data support a model in which the degree of facilitation of opening in the full-length HCN2 channel by a given ligand depends upon its ability to promote oligomerization of the C-linker/cyclic nucleotide-binding domain in solution.
Mouse HCN2-expressing human mesenchymal stem cells are relevant biological models for the generation of biological pacemakers.
the allosteric mechanism of different cyclic nucleotides on the cyclic nucleotide-binding domain of HCN2 and on channel gating, was investigated.
HCN1 (show HCN1 Antibodies), HCN2, and HCN4 (show HCN3 Antibodies) subunits may have distinct physiological roles in the developing hippocampus.
HCN2 channel activity reduces the repolarization reserve of the ventricular action potential and increases ectopic automaticity under pathological conditions such as excessive beta-adrenergic stimulation.
This study demonstrated that Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia.
fisetin is a partial agonist for HCN2 channels.
HCN2 channel expression increases significantly during pregnancy, accelerating the heart rate.
cAMP-dependent changes in the structure of the C-helix of a C-terminal fragment of HCN2 channels
Dendritic expression of the h-channel subunit HCN1 (show HCN1 Antibodies), but not HCN2, was higher in the CA1 (show CA1 Antibodies) region of fmr1 (show FMR1 Antibodies)(-/y) mice.
Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.
hippocampus abundant transcript 1
, hippocampus abundant transcript 1 protein
, hyperpolarization activated cyclic nucleotide-gated potassium channel 2
, brain cyclic nucleotide gated channel 2
, brain cyclic nucleotide-gated channel 2
, potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
, hyperpolarization-activated cation channel 1