anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2) Antibodies

Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM, Jul 2010].. Additionally we are shipping HCN2 Kits (7) and HCN2 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HCN2 610 Q9UL51
HCN2 114244 Q9JKA9
HCN2 15166 O88703
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Top anti-HCN2 Antibodies at antibodies-online.com

Showing 10 out of 71 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from Jurkat cells, using HCN2 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated AA, ICC, IF, IHC, IP, WB HCN2 (S71 37), Human hippocampus. HCN2 Rat Brain Membrane WB. 100 μg Log in to see 2 to 3 Days
$383.90
Details
Mouse Mouse Un-conjugated ICC, IHC, IP, WB 100 μg Log in to see 7 to 9 Days
$551.83
Details
Mouse Rabbit Un-conjugated IHC (p), WB   100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 7 to 9 Days
$478.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of HCN2 expression in SKNSH (A) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Mouse HRP AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-HCN2 Monoclonal Antibody, Clone S71-37 . Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-HCN2 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Rat brain membrane lysate showing detection of HCN2 protein using Mouse Anti-HCN2 Monoclonal Antibody, Clone S71-37 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-HCN2 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$422.40
Details
Human Mouse FITC AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-HCN2 Monoclonal Antibody, Clone S71-37 . Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-HCN2 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Rat brain membrane lysate showing detection of HCN2 protein using Mouse Anti-HCN2 Monoclonal Antibody, Clone S71-37 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-HCN2 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$426.80
Details
Human Mouse Alkaline Phosphatase (AP) AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-HCN2 Monoclonal Antibody, Clone S71-37 . Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-HCN2 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Rat brain membrane lysate showing detection of HCN2 protein using Mouse Anti-HCN2 Monoclonal Antibody, Clone S71-37 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-HCN2 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$429.00
Details
Human Mouse Biotin AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-HCN2 Monoclonal Antibody, Clone S71-37 . Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-HCN2 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Rat brain membrane lysate showing detection of HCN2 protein using Mouse Anti-HCN2 Monoclonal Antibody, Clone S71-37 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-HCN2 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$431.20
Details

HCN2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-HCN2 Antibodies

  1. Human Polyclonal HCN2 Primary Antibody for ELISA, WB - ABIN1535195 : Grimwood, Gordon, Olsen, Terry, Schmutz, Lamerdin, Hellsten, Goodstein, Couronne, Tran-Gyamfi, Aerts, Altherr, Ashworth, Bajorek, Black, Branscomb, Caenepeel, Carrano, Caoile, Chan, Christensen et al.: The DNA sequence and biology of human chromosome 19. ... in Nature 2004 (PubMed)

  2. Human Monoclonal HCN2 Primary Antibody for AA, ICC - ABIN361764 : Zong, Eckert, Yuan, Wahl-Schott, Abicht, Fang, Li, Mistrik, Gerstner, Much, Baumann, Michalakis, Zeng, Chen, Biel: A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase. in The Journal of biological chemistry 2005 (PubMed)

More Antibodies against HCN2 Interaction Partners

Human Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2) interaction partners

  1. HCN2 has a role in maturation and processing of the amyloid precursor protein (show APP Antibodies)

  2. promoter methylation status does not appear to be a major determinant of HCN2 expression in normal and adenoid cystic carcinoma ( ACC )tissues. HCN2 hypomethylation is a biomarker of ACC and may play an important role in the carcinogenesis of ACC.

  3. Aged patients with sinus rhythm exhibited significantly higher expression levels of HCN2 and HCN4 channel mRNA and protein (P<0.05), but significantly lower expression levels of miR1 and 133, compared with those of adult patients with sinus rhythm.

  4. Data show that Rab8b (show RAB8B Antibodies)-interacting protein TRIP8b (show PEX5L Antibodies) does not compete with cyclic AMP (show APRT Antibodies) for the same binding region of hyperpolarization activated cyclic nucleotide gated potassium channel 2 (HCN2).

  5. N-glycosylation is not required for HCN2 channels to function.

  6. Thermal hyperalgesia under chronic inflammatory conditions is mediated by HCN2 channels.

  7. Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner.

  8. HCN2 polymorphism may play a role in chronic inflammatory periodontitis but not in peri (show PLIN1 Antibodies)-implantitis.

  9. LBB-injected HCN2/SkM1 (show SCN4A Antibodies) potentially provides a more clinically suitable biological pacemaker strategy than other reported constructs. This superiority is attributable to the more negative AP threshold and injection into the LBB

  10. HCN2 channels make an important contribution to the maintenance of spontaneous burst activity in embryonic cortical neuron cultures.

Mouse (Murine) Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2) interaction partners

  1. Data support a model in which the degree of facilitation of opening in the full-length HCN2 channel by a given ligand depends upon its ability to promote oligomerization of the C-linker/cyclic nucleotide-binding domain in solution.

  2. Mouse HCN2-expressing human mesenchymal stem cells are relevant biological models for the generation of biological pacemakers.

  3. the allosteric mechanism of different cyclic nucleotides on the cyclic nucleotide-binding domain of HCN2 and on channel gating, was investigated.

  4. HCN1 (show HCN1 Antibodies), HCN2, and HCN4 (show HCN3 Antibodies) subunits may have distinct physiological roles in the developing hippocampus.

  5. HCN2 channel activity reduces the repolarization reserve of the ventricular action potential and increases ectopic automaticity under pathological conditions such as excessive beta-adrenergic stimulation.

  6. This study demonstrated that Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia.

  7. fisetin is a partial agonist for HCN2 channels.

  8. HCN2 channel expression increases significantly during pregnancy, accelerating the heart rate.

  9. cAMP-dependent changes in the structure of the C-helix of a C-terminal fragment of HCN2 channels

  10. Dendritic expression of the h-channel subunit HCN1 (show HCN1 Antibodies), but not HCN2, was higher in the CA1 (show CA1 Antibodies) region of fmr1 (show FMR1 Antibodies)(-/y) mice.

HCN2 Antigen Profile

Protein Summary

Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.

Gene names and symbols associated with HCN2

  • hyperpolarization activated cyclic nucleotide-gated potassium channel 2 (LOC428335) antibody
  • hyperpolarization activated cyclic nucleotide-gated potassium channel 2 (HCN2) antibody
  • hyperpolarization activated cyclic nucleotide-gated potassium channel 2 (Hcn2) antibody
  • hyperpolarization-activated, cyclic nucleotide-gated K+ 2 (Hcn2) antibody
  • BCNG-2 antibody
  • BCNG2 antibody
  • HAC-1 antibody
  • HAC1 antibody
  • HCN2 antibody
  • trls antibody

Protein level used designations for HCN2

hippocampus abundant transcript 1 , hippocampus abundant transcript 1 protein , hyperpolarization activated cyclic nucleotide-gated potassium channel 2 , brain cyclic nucleotide gated channel 2 , brain cyclic nucleotide-gated channel 2 , potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 , BCNG-2 , HAC-1 , hyperpolarization-activated cation channel 1

GENE ID SPECIES
428335 Gallus gallus
100297361 Bos taurus
100540153 Meleagris gallopavo
610 Homo sapiens
114244 Rattus norvegicus
15166 Mus musculus
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