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Hypoxia Inducible Factor 3, alpha Subunit Proteins (HIF3A)

The protein encoded by HIF3A is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). Additionally we are shipping HIF3A Antibodies (77) and HIF3A Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HIF3A 53417 Q0VBL6
HIF3A 64345 Q9JHS2
HIF3A 64344 Q9Y2N7
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Top HIF3A Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,921.50
Details

HIF3A Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human ,
,

More Proteins for Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) Interaction Partners

Cow (Bovine) Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) interaction partners

Zebrafish Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) interaction partners

Mouse (Murine) Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) interaction partners

  1. Report suggests that BV-2 microglial cells express HIF-3a under inflammatory conditions and that its activation differed from that of HIF-1a (show HIF1A Proteins)

  2. mRNA of HIF-2alpha (show EPAS1 Proteins) and Ets-1 (show ETS1 Proteins) were significantly increased by HIF-3alpha ablation. Both factors activate the VE-cadherin (show CDH5 Proteins) gene, the transcriptional repression of these factors by HIF-3alpha is important for silencing the irrelevant expression of the VE-cadherin (show CDH5 Proteins) gene.

  3. our data indicated that Tnni2K175del mutation led to abnormally increased hif3a and decreased vegf in bone, which explain, at least in part, the small body size of Tnni2K175del mice

  4. Anoxia preconditioning increases anti-ischemic neuronal resistance which to a certain extent correlates with the changes of HIF-1alpha (show HIF1A Proteins) and HIF-3alpha expression.

  5. alternative splicing and expression of IPAS is induced by hypoxia.

  6. By generating mice with a targeted disruption of the NEPAS/HIF-3alpha locus, it was found that homozygous mutant mice, NEPAS/HIF-3alpha(-/-), were viable but displayed enlargement of the right ventricle and impaired lung remodeling.

  7. Identity of third HIF alpha class member, HIF-3alpha. mRNA expression information by mouse MTN. Experimental proof of dimerization with ARNT/HIF-1beta (show ARNT Proteins).

Human Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) interaction partners

  1. The association between increased DNA methylation (show HELLS Proteins) at HIF3A and increased adiposity is present in neonates.

  2. HIF3A DNA Methylation Is Associated with Childhood Obesity and ALT

  3. HIF3alpha has a transcriptional regulatory function, which negatively affects gene expression by competing with HIF1alpha (show HIF1A Proteins) and HIF2alpha (show EPAS1 Proteins) in binding to transcriptional elements in target genes during hypoxia. (Review)

  4. A DNA methylation (show HELLS Proteins) variant in HIF3A was associated with BMI changes through interactions with total or supplemental vitamin B2, vitamin B12 (show NDUFB3 Proteins), and folate.

  5. Here we provide evidence for the miRNA mediated regulation of HIF3a by hypoxia responsive miRNAs in STS (show STS Proteins), which may help to tightly regulate and fine-tune the hypoxic response.

  6. The Inhibitory Per/Arnt (show ARNT Proteins)/Sim (show SIM2 Proteins) (PAS (show PASK Proteins)) domain protein (IPAS) is a splice variant of hypoxia-inducible factor (HIF)-3alpha, and possesses two entirely different functions. The results strongly suggest that IPAS is a nucleocytoplasmic shuttling protein.

  7. the transcription of HIF-3alpha4 was silenced by the promoter DNA methylation (show HELLS Proteins) in meningiomas, and inducible HIF-3alpha4 impaired angiogenesis, proliferation, and metabolism/oxidation in hypervascular meningiomas

  8. HIF3A is regulated by hypoxia in the developing human lung.

  9. Hypoxia upregulated transcription from all three alternative HIF-3alpha promoters. siRNA experiments showed that this induction is mediated specifically by HIF-1 (show HIF1A Proteins) and not by HIF-2.

  10. multiple splice variants of locus are targets of the von Hippel-Lindau E3 ubiquitin ligase (show MUL1 Proteins) complex

HIF3A Protein Profile

Protein Summary

The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with HIF3A

  • hypoxia inducible factor 3, alpha subunit (HIF3A)
  • hypoxia-inducible factor 1, alpha subunit, like (hif1al)
  • hypoxia inducible factor 3, alpha subunit (Hif3a)
  • bHLHe17 protein
  • HIF-3A protein
  • HIF3A protein
  • IPAS protein
  • Mop7 protein
  • NEPAS protein
  • PASD7 protein
  • zgc:63965 protein

Protein level used designations for HIF3A

hypoxia inducible factor 3, alpha subunit , Hif3a , Hif3a-like , hypoxia-inducible factor 3 alpha subunit , hypoxia-inducible factor 3-alpha , hypoxia-inducible factor-3 alpha , hypoxia-inducible factor 3-alpha-like , HIF-3-alpha , HIF3-alpha , HIF3-alpha-1 , basic-helix-loop-helix-PAS protein MOP7 , hypoxia inducible factor three alpha , inhibitory PAS domain protein , member of PAS protein 7 , neonatal and embryonic PAS , HIF-3 alpha , HIF3 alpha 1 , hypoxia inducible factor 3 alpha , hypoxia inducible factor 3a , hypoxia-inducible factor 3 alpha , PAS domain-containing protein 7 , class E basic helix-loop-helix protein 17

GENE ID SPECIES
281815 Bos taurus
393376 Danio rerio
456149 Pan troglodytes
100135687 Ovis aries
100413902 Callithrix jacchus
100442498 Pongo abelii
100473029 Ailuropoda melanoleuca
100582446 Nomascus leucogenys
53417 Mus musculus
64345 Rattus norvegicus
64344 Homo sapiens
476429 Canis lupus familiaris
100621574 Sus scrofa
507699 Bos taurus
100071095 Equus caballus
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