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ISL1 encodes a member of the LIM/homeodomain family of transcription factors. Additionally we are shipping ISL LIM Homeobox 1 Proteins (8) and ISL LIM Homeobox 1 Kits (4) and many more products for this protein.
Showing 10 out of 115 products:
Human Monoclonal ISL1 Primary Antibody for IF, ELISA - ABIN561536
Guo, Wang, Zhang, Liu, Chen, Ma, Zhou: ISL1 promotes pancreatic islet cell proliferation. in PLoS ONE 2011
Show all 4 references for ABIN561536
Human Monoclonal ISL1 Primary Antibody for EIA, IF - ABIN1107887
Elshatory, Gan: The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Human Polyclonal ISL1 Primary Antibody for EIA, WB - ABIN952960
Genead, Danielsson, Wärdell, Kjaeldgaard, Westgren, Sundström, Franco-Cereceda, Sylvén, Grinnemo: Early first trimester human embryonic cardiac Islet-1 progenitor cells and cardiomyocytes: Immunohistochemical and electrophysiological characterization. in Stem cell research 2010
Results describe the expression pattern of Xenopus islet-1 (Xisl-1) in the context of cardiovascular development.
Knock-down of Xisl-1 by specific morpholino leads to severe developmental defects, including eye and heart failure.
ISL-1 is widely expressed in Olfactory neuroblastoma (show ARHGEF16 Antibodies) tumors with neuroendocrine differentiation and therefore of limited value in their differential diagnosis
Data indicate that cells cultured on cardiac muscle laminin (LN)-based substrata in combination with stimulation of the canonical Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway showed increased gene expression of ISL1, OCT4 (show POU5F1 Antibodies), KDR (show KDR Antibodies) and NKX2.5 (show NKX2-5 Antibodies).
In bladder exstrophy there is a clear correlation with the a mutation of the chromosome 5 ISL1 (5q11.1) gene.
SSBP3 (show SSBP3 Antibodies) Interacts With Islet-1 and Ldb1 (show LDB1 Antibodies) to Impact Pancreatic beta-Cell Target Genes
Concurrent ISL1/HOXA9 (show HOXA9 Antibodies) methylation in HG-NMIBC reliably predicted tumour recurrence and progression within one year (Positive Predictive Value 91.7%), and was associated with disease-specific mortality
Isl1 overexpression in embryonic stem cells results in normal electrophysiologically functioning cells.
The present study identified the first genome-wide significant locus for classic bladder exstrophy at chromosomal region 5q11.1, and provides strong evidence for the hypothesis that ISL1 is the responsible candidate gene in this region.
Suggest that ISL-1 may be a useful prognostic biomarker and may represent a novel therapeutic target for gastric adenocarcinoma.
Tcf7l2 (show TCF7L2 Antibodies) is regulating proinsulin (show INS Antibodies) expression directly via Isl1, Ins1 (show FOXM1 Antibodies) and indirectly via MafA (show KLRG1 Antibodies), NeuroD1 (show NEUROD1 Antibodies) and Pdx1 (show PDX1 Antibodies).
ISL-1 is tightly linked to non-Hodgkin lymphoma proliferation and development by promoting c-Myc (show MYC Antibodies) transcription, and its aberrant expression was regulated by p-STAT3 (show STAT3 Antibodies)/p-c-Jun (show JUN Antibodies)/ISL-1 complex activation.
Pax2 (show PAX2 Antibodies)-regulated ISL1 overexpression increases the embryonic ISL1(+) domain and induces accelerated nerve fiber extension and branching in E12.5 embryos.
These results show that ISL1 is necessary for maximal thyrotrope response to hypothyroidism, in addition to its role in development of Rathke's pouch.
the Isl1/Ldb1 (show LDB1 Antibodies) complex orchestrates a network for heart-specific transcriptional regulation and coordination in three-dimensional space during cardiogenesis.
All E1 sequences from lamprey to mouse responded equally well to Phox2a (show PHOX2A Antibodies) and the Isl1-Lhx3 (show LHX3 Antibodies) complex. Conversely, E2, the enhancer for limb-innervating motor neurons, was only found in tetrapod animals
Isl1 alternative splicing varies across different retinal cell types. Two isoforms of Isl1 differ functionally as transcriptional activators.
this study gives new insights into transcriptional regulating mechanisms of Wnt (show WNT2 Antibodies)-mediated Isl1 expression during cardiomyocyte differentiation.
results demonstrate that ISL1 regulates approximately one-third of SAN-specific genes, indicate that a combination of ISL1 and other SAN transcription factors could be utilized to generate pacemaker cells
lack both Isl1 and Isl2 (show ISL2 Antibodies), large numbers of motor neurons exited the neural tube, even prior to the appearance of boundary cap cells at the ventral exit points
Tcf7l2 (show TCF7L2 Antibodies) is regulating proinsulin (show INS Antibodies) expression directly via Isl1, Ins1 and indirectly via MafA (show MAFA Antibodies), NeuroD1 (show NEUROD1 Antibodies) and Pdx1 (show PDX1 Antibodies).
Data indicate that LIM-homeodomain (show LHX2 Antibodies) transcription factor Islet 1 is necessary for hypothalamic proopiomelanocortin (show POMC Antibodies) gene (Pomc (show POMC Antibodies)) expression during embryogenesis.
Arx contributes to patterning in the prethalamic region, while Isl1 is required for differentiation of prethalamic dopaminergic neurons.
Ajuba plays a central role in regulating the second heart field during heart development by linking retinoic acid signaling to the function of Isl1, a key transcription factor in cardiac progenitor cells.
Isl1 is required for the selective outgrowth of the peripheral axons of Rohon-beard neurons.
prdm1a (show PRDM1 Antibodies) Regulates sox10 (show SOX10 Antibodies) and islet1 in the development of neural crest and Rohon-Beard sensory neurons.
By direct comparison of the upstream flanking regions of the zebrafish and human isl1 genes, we identified another highly conserved noncoding element.
primary motoneuron subtypes are likely to be specified by factors that act in parallel to or upstream of islet1 and islet2
Nkx6 proteins regulate MiP (show MIP Antibodies) motorneuron development at least in part by maintaining the islet1 expression that is required both to promote the MiP (show MIP Antibodies) subtype and to suppress interneuron development.
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
, ISL1 transcription factor, LIM/homeodomain, (islet-1)
, domesticus (clone 1.7 kB) islet-1
, insulin gene enhancer protein ISL-1
, ISL1 transcription factor, LIM/homeodomain
, ISL1 transcription factor LIM/homeodomain (islet-1)
, ISL1 transcription factor, LIM/homeodomain 1
, isl-1 homeobox
, Insulin gene enhancer protein ISL-1
, Islet 1
, Lim-homeodomain protein Islet1
, insulin related protein
, insulin gene enhancer protein isl-1