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ISL LIM Homeobox 1 Proteins (ISL1)

ISL1 encodes a member of the LIM/homeodomain family of transcription factors. Additionally we are shipping ISL LIM Homeobox 1 Antibodies (115) and ISL LIM Homeobox 1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ISL1 3670 P61371
ISL1 64444 P61374
ISL1 16392 P61372
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Top ISL LIM Homeobox 1 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,948.00
Details
Yeast Mesocricetus auratus His tag   1 mg Log in to see 56 to 66 Days
$2,948.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,948.00
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,948.00
Details

ISL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)

Mouse (Murine)

More Proteins for ISL LIM Homeobox 1 (ISL1) Interaction Partners

Xenopus laevis ISL LIM Homeobox 1 (ISL1) interaction partners

  1. Results describe the expression pattern of Xenopus islet-1 (Xisl-1) in the context of cardiovascular development.

  2. Knock-down of Xisl-1 by specific morpholino leads to severe developmental defects, including eye and heart failure.

Human ISL LIM Homeobox 1 (ISL1) interaction partners

  1. SSBP3 (show SSBP3 Proteins) Interacts With Islet-1 and Ldb1 (show LDB1 Proteins) to Impact Pancreatic beta-Cell Target Genes

  2. Concurrent ISL1/HOXA9 (show HOXA9 Proteins) methylation in HG-NMIBC reliably predicted tumour recurrence and progression within one year (Positive Predictive Value 91.7%), and was associated with disease-specific mortality

  3. Isl1 overexpression in embryonic stem cells results in normal electrophysiologically functioning cells.

  4. The present study identified the first genome-wide significant locus for classic bladder exstrophy at chromosomal region 5q11.1, and provides strong evidence for the hypothesis that ISL1 is the responsible candidate gene in this region.

  5. Suggest that ISL-1 may be a useful prognostic biomarker and may represent a novel therapeutic target for gastric adenocarcinoma.

  6. Tcf7l2 (show TCF7L2 Proteins) is regulating proinsulin (show INS Proteins) expression directly via Isl1, Ins1 (show FOXM1 Proteins) and indirectly via MafA (show KLRG1 Proteins), NeuroD1 (show NEUROD1 Proteins) and Pdx1 (show PDX1 Proteins).

  7. ISL-1 is tightly linked to non-Hodgkin lymphoma proliferation and development by promoting c-Myc (show MYC Proteins) transcription, and its aberrant expression was regulated by p-STAT3 (show STAT3 Proteins)/p-c-Jun (show JUN Proteins)/ISL-1 complex activation.

  8. Overexpression of ISL1 in human mesnchymal stem cells promotes angiogenesis in vitro and in vivo through increasing secretion of MCP3 and other paracrine factors.

  9. ISL1 is commonly expressed in rhabdomyosarcoma, particularly the alveolar subtype

  10. Results suggest that rs1017 ISL1 contributed to the risk of Congenital heart disease (CHD) in Chinese Han people, and the gene may be involved in the formation and development of the heart.

Mouse (Murine) ISL LIM Homeobox 1 (ISL1) interaction partners

  1. These results show that ISL1 is necessary for maximal thyrotrope response to hypothyroidism, in addition to its role in development of Rathke's pouch.

  2. the Isl1/Ldb1 (show LDB1 Proteins) complex orchestrates a network for heart-specific transcriptional regulation and coordination in three-dimensional space during cardiogenesis.

  3. All E1 sequences from lamprey to mouse responded equally well to Phox2a (show PHOX2A Proteins) and the Isl1-Lhx3 (show LHX3 Proteins) complex. Conversely, E2, the enhancer for limb-innervating motor neurons, was only found in tetrapod animals

  4. Isl1 alternative splicing varies across different retinal cell types. Two isoforms of Isl1 differ functionally as transcriptional activators.

  5. this study gives new insights into transcriptional regulating mechanisms of Wnt (show WNT2 Proteins)-mediated Isl1 expression during cardiomyocyte differentiation.

  6. results demonstrate that ISL1 regulates approximately one-third of SAN-specific genes, indicate that a combination of ISL1 and other SAN transcription factors could be utilized to generate pacemaker cells

  7. lack both Isl1 and Isl2 (show ISL2 Proteins), large numbers of motor neurons exited the neural tube, even prior to the appearance of boundary cap cells at the ventral exit points

  8. Tcf7l2 (show TCF7L2 Proteins) is regulating proinsulin (show INS Proteins) expression directly via Isl1, Ins1 and indirectly via MafA (show MAFA Proteins), NeuroD1 (show NEUROD1 Proteins) and Pdx1 (show PDX1 Proteins).

  9. Data indicate that LIM-homeodomain (show LHX2 Proteins) transcription factor Islet 1 is necessary for hypothalamic proopiomelanocortin (show POMC Proteins) gene (Pomc (show POMC Proteins)) expression during embryogenesis.

  10. Pou4f2 (show POU4F2 Proteins) and Isl1, are sufficient to specify the retinal ganglion cell fate in ATOH7 (show ATOH7 Proteins) deficient mice

Zebrafish ISL LIM Homeobox 1 (ISL1) interaction partners

  1. Arx contributes to patterning in the prethalamic region, while Isl1 is required for differentiation of prethalamic dopaminergic neurons.

  2. Ajuba plays a central role in regulating the second heart field during heart development by linking retinoic acid signaling to the function of Isl1, a key transcription factor in cardiac progenitor cells.

  3. Isl1 is required for the selective outgrowth of the peripheral axons of Rohon-beard neurons.

  4. prdm1a (show PRDM1 Proteins) Regulates sox10 (show SOX10 Proteins) and islet1 in the development of neural crest and Rohon-Beard sensory neurons.

  5. By direct comparison of the upstream flanking regions of the zebrafish and human isl1 genes, we identified another highly conserved noncoding element.

  6. primary motoneuron subtypes are likely to be specified by factors that act in parallel to or upstream of islet1 and islet2

  7. Nkx6 proteins regulate MiP motorneuron development at least in part by maintaining the islet1 expression that is required both to promote the MiP subtype and to suppress interneuron development.

ISL LIM Homeobox 1 (ISL1) Protein Profile

Protein Summary

This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.

Gene names and symbols associated with ISL LIM Homeobox 1 Proteins (ISL1)

  • ISL LIM homeobox 1 (isl1)
  • ISL LIM homeobox 1 (ISL1)
  • ISL LIM homeobox 1 (Isl1)
  • ISL1 transcription factor, LIM/homeodomain (Isl1)
  • islet1 (isl1)
  • Isl-1 protein
  • isl-1=homeobox protein
  • Islet-1 protein
  • ISLET1 protein
  • Xisl-1 protein
  • Xislet-1 protein

Protein level used designations for ISL LIM Homeobox 1 Proteins (ISL1)

islet-1 , ISL1 transcription factor, LIM/homeodomain, (islet-1) , domesticus (clone 1.7 kB) islet-1 , insulin gene enhancer protein ISL-1 , ISL1 transcription factor, LIM/homeodomain , ISL1 transcription factor LIM/homeodomain (islet-1) , ISL1 transcription factor, LIM/homeodomain 1 , isl-1 homeobox , Insulin gene enhancer protein ISL-1 , Islet 1 , Lim-homeodomain protein Islet1 , insulin related protein , insulin gene enhancer protein isl-1

GENE ID SPECIES
100126604 Xenopus laevis
396383 Gallus gallus
3670 Homo sapiens
614040 Bos taurus
64444 Rattus norvegicus
101836649 Mesocricetus auratus
16392 Mus musculus
30147 Danio rerio
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