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Immunity-Related GTPase Family, M Proteins (IRGM)

IRGM encodes a member of the p47 immunity-related GTPase family. Additionally we are shipping Immunity-Related GTPase Family, M Antibodies (76) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IRGM 15944 Q60766
IRGM 345611 A1A4Y4
Rat IRGM IRGM 303090 Q6AYC2
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Top Immunity-Related GTPase Family, M Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
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HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
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HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$382.86
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IRGM Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

Top referenced Immunity-Related GTPase Family, M Proteins

  1. Human IRGM Protein expressed in Escherichia coli (E. coli) - ABIN1098712 : Parkes, Barrett, Prescott, Tremelling, Anderson, Fisher, Roberts, Nimmo, Cummings, Soars, Drummond, Lees, Khawaja, Bagnall, Burke, Todhunter, Ahmad, Onnie, McArdle, Strachan, Bethel, Bryan, Lewis et al.: Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. ... in Nature genetics 2007 (PubMed)
    Show all 2 references for ABIN1098712

More Proteins for Immunity-Related GTPase Family, M (IRGM) Interaction Partners

Mouse (Murine) Immunity-Related GTPase Family, M (IRGM) interaction partners

  1. Irgm1-/- embryonic fibroblasts show autophagic flux impairment and defective lysosomal degradation.

  2. Interestingly, we observed that IRGM1 enhanced F-actin polymerization and triggers epithelial mesenchymal transition (EMT) through a mechanism involved in PIK3CA mediated Rac1 activation.

  3. Interferon-beta (show IFNB1 Proteins) activation recruited the immunity-related GTPase (show RACGAP1 Proteins) M1 (IRGM1) to the Toxoplasma gondii-occupied parasitophorous vacuole in peritoneal macrophages and murine embryonic fibroblasts.

  4. these data reveal an Irgm1-dependent mechanism that promotes the tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1 (show SH3GLB1 Proteins)-dependent autophagy

  5. Palmitoylation together with the alphaK helix firmly anchor Irgm1 in the Golgi and mitochondria, thus facilitating function of the protein.

  6. 2 Irgm1 isoforms generated by differential splicing localize to the Golgi apparatus & weakly to mitochondria. Only the long isoforms is seen on endolysosomal membranes. Irgm1 is a negative regulator of the immunity-related GTPase (show RACGAP1 Proteins) protein family.

  7. the paralogous IRGM proteins Irgm1 and Irgm3 fail to robustly associate with "non-self" PVs (show PVRL2 Proteins) containing either the bacterial pathogen Chlamydia trachomatis or the protozoan pathogen Toxoplasma gondii

  8. By 9 weeks post-infection, fewer Brucella abortus were recovered from LRG-47(-/-) mice than controls, suggesting that the host protein has a positive role in maintaining long term persistence of the bacteria within the host.

  9. These results suggest that Irgm1 modulates acute inflammatory responses in the mouse intestine, putatively through the regulation of gut (show GUSB Proteins) autophagic processes, that may be pivotal for proper Paneth cell functioning.

  10. Loss of IRGM1 is associated with impaired CD36 internalization in macrophage, which was associated with the deficiency of F-actin polymerization in atherosclerosis.

Human Immunity-Related GTPase Family, M (IRGM) interaction partners

  1. IRGM functional polymorphisms and haplotypes in promoter were associated with the susceptibility to pulmonary tuberculosis in Chinese Hubei Han population.

  2. In Korean children, IRGM rs1000113 and IRGM rs72553867 exhibited associations with early-onset Crohn Disease as risk loci and defense loci, respectively.

  3. The study confirms IRGM rs13361189 and rs4958847 polymorphisms to be important for Crohn's disease susceptibility and phenotype modulation, in accordance with previous findings.

  4. Expression of viral protein 2C enhanced IRGM promoter activation, thereby increasing IRGM expression and inducing autophagy.

  5. these data reveal an Irgm1-dependent mechanism that promotes the tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1 (show ZBTB24 Proteins)-dependent autophagy

  6. the IRGM(+313), an autophagy-related polymorphic locus, influences outcome in severely septic patients, with the possible involvement of autophagy in sepsis exacerbation

  7. Results show association of IRGM gene SNPs with Crohn's disease in Indian patients and report a new mutation rs 9637876 in the IRGM gene associated with Crohn's disease.

  8. Our findings suggest that expression of IRGM is dysregulated in gastric cancer and that the molecule may affect progression of the disease.

  9. The IRGM rs13361189 polymorphism is promising as a biomarker for early diagnosis of Crohn's disease. However, the IRGM rs10065172 and rs4958847 polymorphisms may not be the major determinants of Crohn's disease risk.

  10. IRGM assembles core autophagy machinery (Beclin 1, Ulk1, ATG16L1) and connects it with innate immunity sensors (NOD2) through formation of protein complex assemblies.

Immunity-Related GTPase Family, M (IRGM) Protein Profile

Protein Summary

This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.

Gene names and symbols associated with IRGM

  • immunity-related GTPase family, M (IRGM)
  • immunity-related GTPase family M member 1 (Irgm1)
  • immunity-related GTPase family, M (Irgm)
  • IFI1 protein
  • Iigp3 protein
  • Iipg3 protein
  • Irgm protein
  • IRGM1 protein
  • LRG-47 protein
  • LRG47 protein

Protein level used designations for IRGM

immunity-related GTPase family M protein , immunity-related GTPase M , immunity-related GTPase family, M , LPS-stimulated RAW 264.7 macrophage protein 47 , immunity-related GTPase family M protein 1 , interferon inducible protein 1 , interferon-inducible GTPase 3 , interferon-inducible protein 1 , LPS-stimulated RAW 264.7 macrophage protein 47 homolog , LRG-47-like protein , immunity-related GTPase family, M1

GENE ID SPECIES
471699 Pan troglodytes
481473 Canis lupus familiaris
15944 Mus musculus
345611 Homo sapiens
606863 Canis lupus familiaris
303090 Rattus norvegicus
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