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Importin 8 Proteins (IPO8)

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. Additionally we are shipping Importin 8 Antibodies (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IPO8 10526 O15397
IPO8 320727 Q7TMY7
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Top Importin 8 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 11 to 13 Days
$827.20
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

IPO8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)
,

More Proteins for Importin 8 (IPO8) Interaction Partners

Human Importin 8 (IPO8) interaction partners

  1. importin (show KPNA4 Proteins) alpha8 functions as a cNLS receptor with distinct cargo specificity, and that heterodimerization by importin (show KPNA4 Proteins) alpha8 is a novel regulatory mode of cNLS binding, in addition to the autoinhibitory regulation by the importin beta (show KPNB1 Proteins) binding domain.

  2. Knockdown of IPO8 reduced the amount of nuclear p65 (show GORASP1 Proteins) following TNF (show TNF Proteins) stimulation. IPO8 binding to p65 (show GORASP1 Proteins) is NLS (show ALDH1A2 Proteins) independent.

  3. TGF-beta (show TGFB1 Proteins)-induced and basal state spontaneous nuclear import of Smad4 (show SMAD4 Proteins) require importin 7 (show IPO7 Proteins) and 8.

  4. IPO8 is the most accurate reference gene for clinical lung specimens.

  5. Study provides evidence that Imp8 is required for cytoplasmic miRNA-guided gene silencing and affects nuclear localization of Ago proteins.

Mouse (Murine) Importin 8 (IPO8) interaction partners

  1. Importin 8 plays a critical role in mediating the cytoplasm-to-nucleus transport of mature miRNAs. IPO8-mediated nuclear transport of mature miRNAs is also dependent on the association of IPO8 with the Argonaute 2 (show EIF2C2 Proteins) complex.

Importin 8 (IPO8) Protein Profile

Protein Summary

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Importin 8 Proteins (IPO8)

  • importin 8 (IPO8)
  • importin 8 (ipo8)
  • importin 8 (Ipo8)
  • 6230418K12Rik protein
  • Abcc10 protein
  • C130009K11Rik protein
  • IPO8 protein
  • MRP7 protein
  • OM-1 protein
  • Om1 protein
  • Ranbp8 protein
  • si:ch211-116i17.1 protein

Protein level used designations for Importin 8 Proteins (IPO8)

importin 8 , importin-8 , RAN binding protein 8 , imp8 , ran-binding protein 8 , ATP-binding cassette, sub-family C (CFTR/MRP), member 10 , oocyte maturation 1

GENE ID SPECIES
418142 Gallus gallus
473395 Pan troglodytes
523408 Bos taurus
555520 Danio rerio
612863 Canis lupus familiaris
10526 Homo sapiens
320727 Mus musculus
Selected quality suppliers for Importin 8 Proteins (IPO8)
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