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Inhibitor of DNA Binding 1, Dominant Negative Helix-Loop-Helix Protein Proteins (ID1)

The protein encoded by ID1 is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. Additionally we are shipping ID1 Antibodies (74) and ID1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ID1 15901  
ID1 25261 P41135
ID1 3397 P41134
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Top ID1 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,374.17
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$498.21
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ID1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , ,
, ,

More Proteins for Inhibitor of DNA Binding 1, Dominant Negative Helix-Loop-Helix Protein (ID1) Interaction Partners

Zebrafish Inhibitor of DNA Binding 1, Dominant Negative Helix-Loop-Helix Protein (ID1) interaction partners

  1. Gain and loss of id1 function in vivo demonstrated that Id1 promotes stem cell quiescence. The increased id1 expression observed in neural stem cells in response to injury appeared independent of inflammatory signals.

Mouse (Murine) Inhibitor of DNA Binding 1, Dominant Negative Helix-Loop-Helix Protein (ID1) interaction partners

  1. demonstrated that Id1 and E2-2 (show TCF4 Proteins) are critical regulators of EPCs function in vitro. Id1 interacts with E2-2 (show TCF4 Proteins) and relieves the E2-2 (show TCF4 Proteins)-mediated repression of FGFR1 (show FGFR1 Proteins) and VEGFR2 (show KDR Proteins) expression to modulate EPCs functions

  2. Endothelial ID1 up-regulation in inflamed colonic mucosa is an adaptive response that modulates the severity of tissue injury.

  3. these findings provide in vivo genetic evidence of Id1 functions as an oncogene (show RAB1A Proteins) in breast cancer

  4. overexpression leads to systemic immunosuppression by downregulation of key molecules involved in dendritic cell differentiation and suppression of CD8 T-cell proliferation, thus promoting primary tumour growth and metastatic progression

  5. ID1/3 are crucial regulators of the adaptive antioxidant-mitochondrial response that promotes beta cell survival during oxidative stress through a novel link to the NFE2L2 (show NFE2L2 Proteins)-small MAF (show MAF Proteins) pathway.

  6. Using genetically modified mice, we found that loss of Id1 inhibited t(8;21) leukemia initiation and progression in vivo by abrogating protein kinase B (AKT)1 (show AKT1 Proteins) activation, and that Id1 interacted with AKT1 (show AKT1 Proteins) through its C terminus.

  7. We conclude that Id1 is potently angiogenic and can be up-regulated in endothelial progenitor cells

  8. Direct interaction between Id1 and Zrf1 (show DNAJC2 Proteins) blocks Zrf1 (show DNAJC2 Proteins) recruitment to chromatin thus impairing neural commitment of embryonic stem cells.During embryonic stem cell differentiation, Id1 levels decrease allowing Zrf1 (show DNAJC2 Proteins) to activate neural genes.

  9. Data indicate that inhibitor of differentiation protein 1 ID1+ cells are self-renewing, multipotent stem/progenitor cells responsible for the long-term renewal of the intestinal epithelium.

  10. Studies demostrated the regulatory role of ID1 in the proliferation and metastasis of colorectal cancer.

Human Inhibitor of DNA Binding 1, Dominant Negative Helix-Loop-Helix Protein (ID1) interaction partners

  1. Peritoneal VEGF-A (show VEGFA Proteins) expression is regulated by TGF-beta1 (show TGFB1 Proteins) through an ID1 pathway in women with endometriosis

  2. Id-1, a protein repressed by miR (show MLXIP Proteins)-29b, facilitates TGFbeta1 (show TGFB1 Proteins)-induced EMT (show ITK Proteins) in human ovarian cancer cells and represents a promising therapeutic target for treating ovarian cancer.

  3. Simultaneous high expression of ID1 and c-Jun or c-Fos was correlated with poor survival in esophageal squamous cell carcinoma patients.

  4. Id1 as an important modulator of molecular events during DPSC commitment and differentiation, which should be considered in dental research on tissue engineering.

  5. Therefore, we identified a tumorigenic role of Id-1 in OS and suggested a potential therapeutic target for OS patients.

  6. these findings provide in vivo genetic evidence of Id1 functions as an oncogene (show RAB1A Proteins) in breast cancer

  7. ID1 overexpression may be associated with higher risk karyotype classification and act as an independent risk factor in young non-M3 acute myeloid leukemia (show BCL11A Proteins) patients.

  8. Advanced melanoma patients, relative to healthy controls, express much higher levels of ID1 in myeloid peripheral blood cells.

  9. LIF (show LIF Proteins) has a role in negatively regulating tumour-suppressor p53 (show TP53 Proteins) through Stat3 (show STAT3 Proteins)/ID1/MDM2 (show MDM2 Proteins) in colorectal cancers

  10. Overexpression of ID1 is associated with colorectal neoplasia.

ID1 Protein Profile

Protein Summary

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ID1

  • inhibitor of DNA binding 1 (id1)
  • inhibitor of DNA binding 1, dominant negative helix-loop-helix protein (ID1)
  • inhibitor of DNA binding 1 (Id1)
  • AI323524 protein
  • bHLHb24 protein
  • cb108 protein
  • D2Wsu140e protein
  • ID protein
  • ID1 protein
  • id6 protein
  • ID125A protein
  • Idb1 protein
  • wu:fb57e11 protein

Protein level used designations for ID1

inhibitor of DNA binding 1 , DNA-binding protein inhibitor id-1 , inhibitor of DNA binding 1, dominant negative helix-loop-helix protein , DNA-binding protein inhibitor ID-1 , inhibitor of DNA binding 6 , Inhibitor of DNA binding 1 helix-loop-helix protein (splice varaiation) , Inhibitor of DNA binding 1, helix-loop-helix protein (splice variation) , class B basic helix-loop-helix protein 24 , dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein) , inhibitor of differentiation 1 , helix-loop-helix protein

GENE ID SPECIES
100528658 Ictalurus punctatus
469912 Pan troglodytes
30493 Danio rerio
15901 Mus musculus
25261 Rattus norvegicus
3397 Homo sapiens
609779 Canis lupus familiaris
100522839 Sus scrofa
497011 Bos taurus
395282 Gallus gallus
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