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The protein encoded by ING3 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. Additionally we are shipping Inhibitor of Growth Family, Member 3 Antibodies (44) and many more products for this protein.
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High ING3 expression is associated with prostate cancer.
ING3 levels may serve as a surrogate for growth rate, and suggest possible roles for ING3 in growth and self renewal and related diseases such as cancer.
Downregulated ING3 expression might play an important role in colorectal adenoma-adenocarcinoma sequence.
that ING3 may be an important marker for human hepatocellular carcinoma progression and prognosis, as well as a potential therapeutic target.
Data show that ING3 is degraded by the ubiquitin-proteasome pathway through the SCF(Skp2) complex.
we have isolated a novel ING family gene, p47ING3, which modulates p53 (show TP53 Proteins)-mediated transcription, cell cycle control, and apoptosis. The p47ING3 gene is located at chromosome 7q31.3 and consists of 12 exons that encode 418 amino acids
ING3 may be an important marker for human melanoma progression and prognosis as well as a potential therapeutic target.
ING3 would function as a potential tumor suppressor molecule and that low levels of ING3 may indicate an aggressive nature of head and neck cancer.
Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers.
ING3 is essential for asymmetric cell division during mouse oocyte maturation
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
inhibitor of growth family, member 3
, inhibitor of growth protein 3
, inhibitor of growth protein 3-like
, p47 regulator protein