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ING4 encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. Additionally we are shipping Inhibitor of Growth Family, Member 4 Antibodies (51) and Inhibitor of Growth Family, Member 4 Kits (1) and many more products for this protein.
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ING4 can facilitate cancer cell sensitivity to chemotherapy and radiotherapy. Although ING4 loss is observed for many types of cancers, increasing evidences show that ING4 can be used for gene therapy. In this review, the recent progress of ING4 regulating tumorigenesis is discussed
ING4 inhibits CRC (show CALR Proteins) invasion and metastasis probably via a switch from mesenchymal marker N-cadherin (show CDH2 Proteins) to epithelial marker E-cadherin (show CDH1 Proteins) through downregulation of Snail1 (show SNAI1 Proteins) epithelial-mesenchymal transition (EMT (show ITK Proteins))-inducing transcription factor (EMT (show ITK Proteins)-TF).
Data show that Ras protein regulates inhibitor of growth protein 4 (ING4)-thymine-DNA glycosylase (TDG (show TDG Proteins))-Fas (show FAS Proteins) protein axis to promote apoptosis resistance in pancreatic cancer.
MiR (show MLXIP Proteins)-761 directly targeted ING4 and TIMP2 (show TIMP2 Proteins).
Data suggest a close connection between aberrant ING4 expression and the carcinogenesis of human bladder cells.
This review summarizes the recent published literature that investigates the role of ING4 in regulating tumorigenesis and progression, and explores its potential for cancer treatment. [review]
SCF (show KITLG Proteins)(JFK (show FBXO42 Proteins)) as a bona fide E3 ligase for ING4 and unraveled the JFK (show FBXO42 Proteins)-ING4-NF-kappaB (show NFKB1 Proteins) axis as an important player in the development and progression of breast cancer
work suggests that ING4 can suppress osteosarcoma progression through signaling pathways such as mitochondria pathway and NF-kappaB (show NFKB1 Proteins) signaling pathway and ING4 gene therapy is a promising approach to treating osteosarcoma.
The enhanced antitumor activity generated by Ad.RGD-ING4-PTEN was closely associated with activation of the intrinsic and extrinsic apoptotic pathways and additive inhibition of tumor angiogenesis both in vitro and in vivo.
The low expression level of ING4 protein was correlated with high-risk gastrointestinal stromal tumors.
Inhibitor of growth (show ING1 Proteins)-4 promotes IkappaB promoter activation to suppress NF-kappaB (show NFKB1 Proteins) signaling and innate immunity
Report down-regulation of the inhibitor of growth family member 4 (ING4) in different forms of pulmonary fibrosis.
This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins.
inhibitor of growth protein 4
, inhibitor of growth family, member 4
, brain my036 protein
, candidate tumor suppressor p33 ING1 homolog
, ING1-like protein