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ING4 encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. Additionally we are shipping Inhibitor of Growth Family, Member 4 Antibodies (49) and Inhibitor of Growth Family, Member 4 Kits (1) and many more products for this protein.
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MiR (show MLXIP Proteins)-761 directly targeted ING4 and TIMP2 (show TIMP2 Proteins).
Data suggest a close connection between aberrant ING4 expression and the carcinogenesis of human bladder cells.
This review summarizes the recent published literature that investigates the role of ING4 in regulating tumorigenesis and progression, and explores its potential for cancer treatment. [review]
SCF (show KITLG Proteins)(JFK (show FBXO42 Proteins)) as a bona fide E3 ligase for ING4 and unraveled the JFK (show FBXO42 Proteins)-ING4-NF-kappaB (show NFKB1 Proteins) axis as an important player in the development and progression of breast cancer
work suggests that ING4 can suppress osteosarcoma progression through signaling pathways such as mitochondria pathway and NF-kappaB (show NFKB1 Proteins) signaling pathway and ING4 gene therapy is a promising approach to treating osteosarcoma.
The enhanced antitumor activity generated by Ad.RGD-ING4-PTEN was closely associated with activation of the intrinsic and extrinsic apoptotic pathways and additive inhibition of tumor angiogenesis both in vitro and in vivo.
The low expression level of ING4 protein was correlated with high-risk gastrointestinal stromal tumors.
loss of ING4, either directly or indirectly through loss of Pten, promotes Myc (show MYC Proteins)-driven prostate oncogenesis.
ING4 level elevation mediated proliferation and invasion inhibition may be tightly associated with the suppression of NF-kappaB (show NFKB1 Proteins) signaling pathway.
These findings support a critical role for ING4 expression in normal cells in the non-cell-autonomous regulation of tumor growth.
Inhibitor of growth (show ING1 Proteins)-4 promotes IkappaB promoter activation to suppress NF-kappaB (show NFKB1 Proteins) signaling and innate immunity
Report down-regulation of the inhibitor of growth family member 4 (ING4) in different forms of pulmonary fibrosis.
This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins.
inhibitor of growth protein 4
, inhibitor of growth family, member 4
, brain my036 protein
, candidate tumor suppressor p33 ING1 homolog
, ING1-like protein