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Inosine Triphosphatase Proteins (ITPA)

ITPA encodes an inosine triphosphate pyrophosphohydrolase. Additionally we are shipping Inosine Triphosphatase Antibodies (72) and Inosine Triphosphatase Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ITPA 3704 Q9BY32
ITPA 311422 D3ZW55
ITPA 16434 Q9D892
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Top Inosine Triphosphatase Proteins at antibodies-online.com

Showing 10 out of 22 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast REACT_Sea Squirt His tag   1 mg Log in to see 56 to 66 Days
$2,460.33
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,469.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,476.83
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,489.67
Details
Yeast REACT_Maize/Corn His tag   1 mg Log in to see 56 to 66 Days
$2,489.67
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,495.17
Details

ITPA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

Mouse (Murine)

Top referenced Inosine Triphosphatase Proteins

  1. Human ITPA Protein expressed in Escherichia coli (E. coli) - ABIN667158 : Clawson, Song, Schwartz, Shukla, Patel, Connor, Blankenship, Hatem, Kumar: Interaction of human immunodeficiency virus type I Rev protein with nuclear scaffold nucleoside triphosphatase activity. in Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1992 (PubMed)
    Show all 2 references for ABIN667158

  2. Human ITPA Protein expressed in Wheat germ - ABIN1308243 : Bierau, Bakker, Schippers, Grashorn, Lindhout, Lowe, Paulussen, Verbon: Erythrocyte inosine triphosphatase activity is decreased in HIV-seropositive individuals. in PLoS ONE 2012 (PubMed)

More Proteins for Inosine Triphosphatase (ITPA) Interaction Partners

Human Inosine Triphosphatase (ITPA) interaction partners

  1. Genetic variants in inosine triphosphatase (ITPA) gene have been linked to the haemolytic anaemia induced by peg (show PAEP Proteins)-interferon (show IFNA Proteins) and ribavirin treatment.

  2. The association of IL28B (show IL28B Proteins) and APOH (show APOH Proteins) single nucleotide polymorphisms (SNPs) with sustained virological response and of ITPA SNPs with anemia related phenotypes.

  3. The identification of ITPA protective and SLC29A1 (show SLC29A1 Proteins) risk genotypes still appears to be a current methodology in Ribavirin dosing during hepatitis C virus therapy with direct acting antiviral agents

  4. ITPA SNPs in Brazilian patients receiving antiviral therapy for chronic hepatitis had a great propensity for developing ribavirin-induced anaemia.

  5. genotyping of ATIC (show ATIC Proteins) rs2372536 and ITPA rs1127354 variants or measuring ITPA activity could be useful to predict methotrexate response in children with juvenile idiopathic arthritis.

  6. Recessive ITPA mutations were associated with early infantile encephalopathy.

  7. results showed that patients with aberrant ITPase genotype (mutant homozygous or heterozygous), more likely to be myelosuppressed and show liver toxicity after treatment with 6-Mercaptopurine

  8. The ITPA SNP rs1127354 is a useful predictor of ribavirin-induced anemia in Taiwanese patients and may be related to more severe decreases in platelet counts during the early stage of HCV combination therapy.

  9. Results indicate a strong, significant, and independent role of VDR (show CYP27B1 Proteins) in the early development of ribavirin-induced anemia and confirm the ITPA function in the prediction of anemia at week 4.

  10. ITPA polymorphisms are associated with an improved likelihood of achieving sustained virological response resulting from the reduced risk of relapse following IFN and ribavirin combination therapy for HCV infection

Mouse (Murine) Inosine Triphosphatase (ITPA) interaction partners

  1. In the mouse genome, we found one processed Itpa gene-like sequence and two processed Itpa pseudogenes as well as the Itpa gene itself with introns.

  2. The role of ITPase in mice is to exclude ITP from the ATP pool, and the main target substrate of this enzyme is rITP

Inosine Triphosphatase (ITPA) Protein Profile

Protein Summary

This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with Inosine Triphosphatase Proteins (ITPA)

  • inosine triphosphatase (itpa)
  • inosine triphosphatase (LOC100345066)
  • inosine triphosphatase (LOC733043)
  • inosine triphosphatase (LOC100157088)
  • inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA)
  • inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (Itpa)
  • inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (itpa)
  • LOC100283993 (pco148511)
  • nucleoside-triphosphatase, cancer-related (NTPCR)
  • 2010016I08Rik protein
  • AU020102 protein
  • C1orf57 protein
  • C20orf37 protein
  • DDBDRAFT_0215619 protein
  • DDBDRAFT_0238062 protein
  • DDB_0215619 protein
  • DDB_0238062 protein
  • dJ794I6.3 protein
  • HCR-NTPase protein
  • HLC14-06-P protein
  • Itp protein
  • ITPase protein
  • NTPase protein
  • RP4-678E16.2 protein
  • si:ch73-18j6.1 protein
  • si:dkey-19f21.1 protein

Protein level used designations for Inosine Triphosphatase Proteins (ITPA)

inosine triphosphate pyrophosphatase , inosine triphosphatase , ITPase , NTPase , inosine triphosphatase-A , inosine triphosphate pyrophosphohydrolase , non-canonical purine NTP pyrophosphatase , non-standard purine NTP pyrophosphatase , nucleoside-triphosphate diphosphatase , putative oncogene protein HLC14-06-P , nucleoside-triphosphate pyrophosphatase , nucleoside triphosphate pyrophosphatase , inosine triphosphatase A , Non-canonical purine NTP pyrophosphatase , Non-standard purine NTP pyrophosphatase , Nucleoside-triphosphate diphosphatase , Nucleoside-triphosphate pyrophosphatase , Inosine triphosphatase , PCO148511_ov , hypothetical protein , pco148511(169) , cancer-related nucleoside-triphosphatase , human cancer-related NTPase , nucleoside triphosphate phosphohydrolase , nucleoside-triphosphatase C1orf57

GENE ID SPECIES
8625642 Dictyostelium discoideum AX4
100345066 Oryctolagus cuniculus
733043 Bombyx mori
100157088 Sus scrofa
3704 Homo sapiens
311422 Rattus norvegicus
16434 Mus musculus
613653 Bos taurus
424390 Gallus gallus
735008 Xenopus laevis
557834 Danio rerio
100283993 Zea mays
84284 Homo sapiens
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