ITPA Protein (His tag)

Catalog No. ABIN7318619

Product Details

Target: ITPA (Inosine Triphosphatase (ITPA))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This ITPA protein is labelled with His tag.

Purpose: Recombinant Human ITPase/ITPA Protein (His Tag)

Sequence: Ala2-Ala194

Characteristics: Recombinant Human Inosine Triphosphate Pyrophosphatase is produced by our E.coli expression system and the target gene encoding Ala2-Ala194 is expressed with a 6His tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, pH 8.0.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: ITPA (Inosine Triphosphatase (ITPA))

Alternative Name: ITPase/ITPA (ITPA Products)

Synonyms: DDBDRAFT_0215619 Protein, DDBDRAFT_0238062 Protein, DDB_0215619 Protein, DDB_0238062 Protein, 2010016I08Rik Protein, AU020102 Protein, Itp Protein, C20orf37 Protein, HLC14-06-P Protein, dJ794I6.3 Protein, ITPase Protein, NTPase Protein, si:ch73-18j6.1 Protein, si:dkey-19f21.1 Protein, inosine triphosphatase Protein, inosine triphosphatase (nucleoside triphosphate pyrophosphatase) Protein, Inosine triphosphate pyrophosphatase Protein, inosine triphosphatase S homeolog Protein, itpa Protein, ITPA Protein, LOC733043 Protein, Itpa Protein, pco148511 Protein, itpa.S Protein

Background:

Background: Inosine Triphosphate Pyrophosphatase (ITPase) is a cytoplasmic enzyme that belongs to the HAM1 NTPase family. ITPase hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP) and deoxyinosine triphosphate (dITP) to the monophosphate nucleotide (IMP) and diphosphate. The ITPase enzyme acts as a homodimer and does not distinguish between the deoxy- and ribose forms. ITPase probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Defects in ITPase is thought to be inherited and is characterized by an over-accumulation of ITP in erythocytes, leukocytes and fibroblasts.

Synonym: Inosine Triphosphate Pyrophosphatase, ITPase, Inosine Triphosphatase, Non-Canonical Purine NTP Pyrophosphatase, Non-Standard Purine NTP Pyrophosphatase, Nucleoside-Triphosphate Diphosphatase, Nucleoside-Triphosphate Pyrophosphatase, NTPase, Putative Oncogene Protein hlc14-06-p, ITPA, C20orf37

Molecular Weight: 22.5 kDa

UniProt: Q9BY32