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Inositol Polyphosphate-5-Phosphatase, 75kDa Proteins (INPP5B)

Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. Additionally we are shipping INPP5B Antibodies (35) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
INPP5B 16330 Q8K337
Rat INPP5B INPP5B 362590  
INPP5B 3633 P32019
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Top INPP5B Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

INPP5B Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Inositol Polyphosphate-5-Phosphatase, 75kDa (INPP5B) Interaction Partners

Mouse (Murine) Inositol Polyphosphate-5-Phosphatase, 75kDa (INPP5B) interaction partners

  1. study found mouse Inpp5b and human INPP5B differ in their transcription, splicing and amino acid sequence; observations form foundation for analyzing the functional basis for the difference in how Inpp5b and INPP5B compensate for loss of Ocrl (show OCRL Proteins) function

  2. ADAM cleavage was only modestly impaired in numerous Inpp5b-null males and varied between individual animals.

  3. These results indicate a functional overlap of Ocrl (show OCRL Proteins) and Inpp5b in most cell lineages, especially in extraembryonic tissues.

  4. Inpp5b role in the regulation of cell adhesion in the testis and in the formation of junctional complexes with neighboring cells

  5. 72-5ptase expression promoted GLUT4 (show SLC2A4 Proteins) trafficking via a Rab11 (show RAB11A Proteins)-dependent pathway but not by Rab5 (show RAB5A Proteins)-mediated endocytosis. Therefore, endogenous PtdIns(3)P at the plasma membrane promotes GLUT4 (show SLC2A4 Proteins) translocation.

Human Inositol Polyphosphate-5-Phosphatase, 75kDa (INPP5B) interaction partners

  1. OCRL (show OCRL Proteins)-mutated fibroblasts from patients with Dent-2 disease exhibit INPP5B-independent phenotypic variability relatively to Lowe syndrome cells

  2. The crystal structures of human INPP5B in complex with phosphoinositide substrate analogs revealed a membrane interaction patch likely to assist in sequestering substrates from the lipid bilayer.

  3. study found mouse Inpp5b and human INPP5B differ in their transcription, splicing and amino acid sequence; observations form foundation for analyzing the functional basis for the difference in how Inpp5b and INPP5B compensate for loss of Ocrl (show OCRL Proteins) function

  4. The homologous phosphatase Inpp5b was unable to complement the Ocrl1 (show OCRL Proteins)-dependent cell migration defect.

  5. INPP5B is also localised to the early secretory pathway including the Golgi apparatus and ER-to-Golgi intermediate compartment (ERGIC).

  6. The NH2-terminal region of OCRL, but not of INPP5B, binds clathrin heavy chain.

INPP5B Protein Profile

Protein Summary

Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Gene names and symbols associated with INPP5B

  • inositol polyphosphate-5-phosphatase, 75kDa (INPP5B)
  • inositol polyphosphate-5-phosphatase, 75kDa (LOC100224437)
  • inositol polyphosphate-5-phosphatase, 75kDa (LOC100350043)
  • inositol polyphosphate-5-phosphatase, 75kDa (inpp5b)
  • inositol polyphosphate-5-phosphatase B (Inpp5b)
  • 5PTase protein
  • 75kDa protein
  • AW260155 protein
  • INPP5P protein

Protein level used designations for INPP5B

inositol polyphosphate-5-phosphatase, 75kDa , inositol polyphosphate-5-phosphatase, 75kDa-like , type II inositol-1,4,5-trisphosphate 5-phosphatase-like , 5PTase , inositol polyphosphate-5-phosphatase, 75 kDa , phosphoinositide 5-phosphatase , type II inositol 1,4,5-trisphosphate 5-phosphatase , type II inositol-1,4,5-trisphosphate 5-phosphatase , 75 kDa inositol polyphosphate-5-phosphatase

GENE ID SPECIES
419609 Gallus gallus
456767 Pan troglodytes
538291 Bos taurus
716851 Macaca mulatta
100054559 Equus caballus
100224437 Taeniopygia guttata
100350043 Oryctolagus cuniculus
100381066 Xenopus laevis
100159919 Acyrthosiphon pisum
100512110 Sus scrofa
16330 Mus musculus
362590 Rattus norvegicus
3633 Homo sapiens
100686373 Canis lupus familiaris
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