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The protein encoded by IGFALS is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Additionally we are shipping Insulin-Like Growth Factor Binding Protein, Acid Labile Subunit Kits (12) and Insulin-Like Growth Factor Binding Protein, Acid Labile Subunit Proteins (4) and many more products for this protein.
Showing 10 out of 42 products:
Human Polyclonal IGFALS Primary Antibody for ELISA, WB - ABIN1451835
Suwanichkul, Boisclair, Olney, Durham, Powell: Conservation of a growth hormone-responsive promoter element in the human and mouse acid-labile subunit genes. in Endocrinology 2000
Show all 2 references for ABIN1451835
Human Polyclonal IGFALS Primary Antibody for WB - ABIN2775293
Heath, Argente, Barrios, Pozo, Díaz-González, Martos-Moreno, Caimari, Gracia, Campos-Barros: Primary acid-labile subunit deficiency due to recessive IGFALS mutations results in postnatal growth deficit associated with low circulating insulin growth factor (IGF)-I, IGF binding protein-3 levels, and hyperinsulinemia. in The Journal of clinical endocrinology and metabolism 2008
Human Polyclonal IGFALS Primary Antibody for FACS, IHC (p) - ABIN391690
Leong, Baxter, Camerato, Dai, Wood: Structure and functional expression of the acid-labile subunit of the insulin-like growth factor-binding protein complex. in Molecular endocrinology (Baltimore, Md.) 1992
Mutations in the IGFALS and low expression level of IGFALS proteins lead to growth and development retardation. [Review]
A novel homozygous mutation in IGFALS, c.380T>C (p.L127P), was identified in two siblings of a consanguineous family.
Heterozygous IGFALS gene variants could be responsible for short stature in a subset of idiopathic short stature children with diminished levels of IGF-1, IGFBP-3 and ALS.
These gene dosage effects demonstrate that one functional IGFALS allele is insufficient to maintain normal ALS levels, endocrine IGF-I (show IGF1 Antibodies) action, full growth potential, muscle size, and periosteal expansion.
functional analysis supported a tumor-suppressive function for IGFALS in vitro.
Heterozygous STAT5B (show STAT5B Antibodies) mutations, with or without heterozygous IGFALS defects, may be associated with growth hormone (show GH1 Antibodies) insensitivity.
low circulating IGF-I (show IGF1 Antibodies) levels due to Acid-Labile Subunit deficiency in adulthood are not associated with early development of atherosclerosis and impaired heart function.
D440N mutation in ALS generates a hyperglycosylated form with impaired secretion and complex formation, potentially leading to dysregulation of endocrine IGF, thus contributing to growth retardation
Common genetic variation in the IGF1 (show IGF1 Antibodies) and SSTR5 (show SSTR5 Antibodies) genes seems to influence circulating IGF-I (show IGF1 Antibodies) levels
We describe that the human placenta expresses the mRNA and the protein for ALS, and we observed an increase in ALS mRNA expression and protein content in small compared with appropriate for gestational age placentas.
the Igfals gene has a role in skeletal response of male mice to anabolic hormone therapy
A modest reduction in post-natal growth in the null ALS mice and in the ALS-deficient patients was observed
The isolation and characterization of the IGFALS gene, including its expression profile and variations, are reported.
Polymorphisms in the IGFALS gene are associated with growth traits in beef cattle (Bos taurus) in China.
The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene.
insulin-like growth factor binding protein, acid labile subunit
, insulin-like growth factor-binding protein complex acid labile subunit-like
, insulin-like growth factor binding protein complex acid labile chain
, insulin-like growth factor-binding protein complex acid labile subunit
, insulin-like growth factor binding protein complex acid-labile subunit
, insulin-like growth factor-binding protein complex acid labile chain
, insulin-like growth factor binding protein, acid-labile subunit