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IGFBP3 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. Additionally we are shipping IGFBP3 Antibodies (189) and IGFBP3 Proteins (41) and many more products for this protein.
Showing 10 out of 111 products:
Rat (Rattus) IGFBP3 ELISA Kit for Sandwich ELISA - ABIN416321
Qin, Tian: Characterization of the specific and sustained GH1 expression induced by rAAV2/1 in normal adult male rats. in Molecular biology reports 2010
Show all 3 references for ABIN416321
Mouse (Murine) IGFBP3 ELISA Kit for Sandwich ELISA - ABIN1672736
Ehrenborg, Larsson, Stern, Janson, Powell, Luthman: Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7. in Genomics 1992
Show all 3 references for ABIN1672736
Human IGFBP3 ELISA Kit for Sandwich ELISA - ABIN414870
Palau, Rebuffat, Altirriba, Piquer, Hanzu, Gomis, Barbera: Role of IGFBP-3 in the regulation of ?-cell mass during obesity: adipose tissue/?-cell cross talk. in Endocrinology 2011
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insulin-like growth factor binding protein 3 exerts its ligand-independent action by antagonizing bone morphogenetic protein 2 (show BMP4 ELISA Kits) in zebrafish embryos
IGFBP-3 plays an important role in regulating pharyngeal cartilage and inner ear development and growth in zebrafish.
Study showed that IGFBP3 is dramatically induced in pancreatic tumors, and is abundantly produced in pancreatic cancer cells, causing muscle wasting through both impaired myogenesis via, at least, inhibition of IGF/PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) signaling.
The ratios of IGF-I (show IGF1 ELISA Kits)/IGFBP-3 were increased in postmenopausal Taiwanese women with breast cancer, irrespective of their ages, ER and PR statuses, and HER2 (show ERBB2 ELISA Kits) expression.
Higher IGF-I (show IGF1 ELISA Kits) levels among postmenopausal women and an elevated IGF-I:IGFBP-3 ratio among all women were associated with higher TDLU counts ; these associations were strongest among women with elevated mammographic density
Insulin (show INS ELISA Kits)-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells via integrin beta1 signaling.
endogenous IGFBP-3 is a p53 (show TP53 ELISA Kits) target that plays a role in breast cancer cell responsiveness to DNA damaging therapy
Metformin resulted in a significant reduction of IGF-1 (show IGF1 ELISA Kits), IGF-1 (show IGF1 ELISA Kits): IGFBP-3 molar ratio, insulin (show INS ELISA Kits), FBG and HOMA-IR. On the other hand, metformin caused a significant increase of IGFBP-3.
Data indicate that IGF-binding protein 3 (IGFBP3) and F3 gene expression levels in formalin fixed paraffin embedded (FFPE) prostate cancer tissue would provide an improved survival prediction for prostate cancer patients.
calcineurin (show PPP3CA ELISA Kits) in astrocytes was activated by Amyloid beta, leading to IGFBP-3 release.
Circulating levels of IGF-1 (show IGF1 ELISA Kits), IGFBP-3 and their molar ratio were not associated with the risk of occurrence of colorectal adenoma
Independent of obesity, high insulin (show INS ELISA Kits) levels but reduced levels of IGFBP-3 were associated with increased lung cancer risk in current smokers.
IGFBP-3 is an aggravating factor during hepatic ischemia-repefusion injury.
An increase in IGFBP-3 post-trauma may play an important role in limiting trauma-induced inflammatory and apoptotic pathways leading to retinal damage.
Even though knockout of IGFBP-3 is associated with only a subtle phenotype under control conditions, our results reveal that loss of this gene has measurable effects on breast carcinogenesis and breast cancer metastasis.
Igfbp3 is a marker for culture-activated hepatic stellate cells and plays a role in HSC (show FUT1 ELISA Kits) migration.
Igfbp2 (show IGFBP2 ELISA Kits)-5 are expressed in distinct and complementary patterns during cochlear development.
IGFBP-3 has novel protective effects on retinal and systemic vasculature and may be a therapeutic candidate for ocular complications such as diabetic retinopathy.
IGFBP-3 activates inhibitory Smad (show SMAD1 ELISA Kits) signaling in 3T3-L1 cells and that endogenous IGFBP-3 modulates their adipogenic differentiation by regulating cell sensitivity towards the inhibitory effect of TGFbeta (show TGFB1 ELISA Kits).
Wnt (show WNT2 ELISA Kits) signaling exerts an antiproliferative effect on adult cardiac progenitor cells through IGFBP3.
IGFBP-3 positively and negatively impacts on IGF1 (show IGF1 ELISA Kits)-induced lung cancer development.
Bone morphogenetic protein-1 (show BMP1 ELISA Kits) processes insulin-like growth factor-binding protein 3.
These data suggest that endogenous IGFBP-3 plays a role in intrinsic apoptosis by facilitating phosphorylation and nuclear export of Nur77 (show NR4A1 ELISA Kits) to the cytoplasm where it exerts its apoptotic effect.
The present study suggests that the insulin (show INS ELISA Kits) like growth factor (IGF) system or imbalances between IGF and IGF binding (show HTRA1 ELISA Kits) proteins may be involved in cystic ovary disease of cattle.
spatial and temporal patterns of expression of IGFBP-2 (show IGFBP2 ELISA Kits) and -3 were markedly altered in the placentomes of nuclear transfer pregnancies
stimulation of IGFBP-3 mRNA levels by mitogens is regulated through both the PI3K and MAPK (show MAPK1 ELISA Kits) pathways in bovine mammary epithelial cells
Preincubation of erythroid cells with thrombospondin 1 (show THBS1 ELISA Kits) eliminated the inhibitory activity of IGFBP-3
GH, IGF-I (show IGF1 ELISA Kits) and IGF-IBP3 regulated the growth and development traits in different growth period.
delivery of insulin-like growth factor-1 (IGF-1 (show IGF1 ELISA Kits), delivered at concentrations of 0, 10, 50, and 100 ng/mL) affects the endogenous expression of IGF-1 (show IGF1 ELISA Kits), its receptor (IGF-1R (show IGF1R ELISA Kits)), and a well known IGF-1 (show IGF1 ELISA Kits) binding protein (IGFBP-3) by articular chondrocytes
Multivariable adjusted analyses did not reveal a statistically significant linear relationship between IGF1 (show IGF1 ELISA Kits) or IGFBP3 concentrations or their molar ratio and risk of myocardial infarction
Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells.
IGF-I (show IGF1 ELISA Kits), IGF-II, and IGFBP-3 mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.
Increased oxidative stress from high glucose enhances IGFBP-3 expression, inducing apoptosis
Even though LRP-1 (show LRP1 ELISA Kits) mRNA and protein levels were dramatically reduced in LRP-1 (show LRP1 ELISA Kits)-silenced L6 cells compared with mock-silenced controls, rpIGFPB-3 suppressed proliferation rate to the same extent in both LRP-1 (show LRP1 ELISA Kits)-silenced and mock-silenced cultures.
cloning and sequencing; regulation of IGFBP-3 transcription by FSH (show BRD2 ELISA Kits) suggests a role for IGFBP-3 in follicular development that may be independent of IGF-I (show IGF1 ELISA Kits)
Follicle-stimulating hormone stimulation of IGFBP-3 transcription is mediated by cAMP via the PKA pathway and requires the P1-3 kinase and likely the MAPK (show MAPK1 ELISA Kits) pathways.
TAF4b may thus be the TFIID (show TBP ELISA Kits) component that binds to the TBP (show TBP ELISA Kits) site on the IGFBP-3 promoter and is essential for FSH (show BRD2 ELISA Kits) induction of IGFBP-3.
The results suggest that the expression of IGF2 and IGFBP3 mRNA in the adipose tissue of pigs exhibits specific developmental changes and different patterns between the two pig breeds.
allelic frequency of TAT (show C6orf134 ELISA Kits) in Chinese breeds was over 50%; allelic frequency of GGC (show GGCT ELISA Kits) was over 50% in all European breeds. TAT/TAT (show C6orf134 ELISA Kits) pigs scored higher in meat color than GGC/GGC (show GGCT ELISA Kits) pigs. results implied that IGFBP-3 may affect meat quality & carcass traits.
Data suggest that metabolism of IGFBP3, IGF1 (insulin-like growth factor I), and IGF2 (insulin-like growth factor II) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
insulin-like growth factor-binding protein 3
, insulin-like growth factor binding protein 3
, IGF-binding protein 3
, acid stable subunit of the 140 K IGF complex
, binding protein 29
, binding protein 53
, growth hormone-dependent binding protein
, insulin-like growth factor binding protein-3
, insulin-like growth factor-binding protein (IGF-BP3)