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IGFBP7 encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. Additionally we are shipping Insulin-Like Growth Factor Binding Protein 7 Antibodies (110) and Insulin-Like Growth Factor Binding Protein 7 Kits (31) and many more products for this protein.
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Human IGFBP7 Protein expressed in HEK-293 - ABIN2666960
Nagakubo, Murai, Tanaka, Usui, Matsumoto, Sekiguchi, Miyasaka: A high endothelial venule secretory protein, mac25/angiomodulin, interacts with multiple high endothelial venule-associated molecules including chemokines. in Journal of immunology (Baltimore, Md. : 1950) 2003
Show all 6 references for ABIN2666960
Human IGFBP7 Protein expressed in Human Cells - ABIN2005452
Gommans, Tatalias, Sie, Dupuis, Vendetti, Smith, Kaushal, Maas: Screening of human SNP database identifies recoding sites of A-to-I RNA editing. in RNA (New York, N.Y.) 2008
Show all 5 references for ABIN2005452
data suggest that TGF-beta1 (show TGFB1 Proteins) enhances IGFBP7 via Smad2 (show SMAD2 Proteins)/4 pathways, and that IGFBP7 might be involved in the TGF-beta1 (show TGFB1 Proteins)-induced tubular injury in DN.
This study shows that urinary [TIMP-2 (show TIMP2 Proteins)]*[IGFBP7] has a good diagnostic performance in predicting adverse outcomes in neonatal and pediatric AKI of heterogeneous etiology.
Inhibition of IGF1 (show IGF1 Proteins)-R overcomes IGFBP7-induced chemotherapy resistance in T-ALL
serum IGFBP7 levels are associated with IR and MetS, providing new insight into the mechanism of IR and Mets. IGFBP7 may be a potential interventional target for IR and Mets.
IGFBP-7 can alter EMT (show ITK Proteins) relative marker genes and suppress cell invasion in A253 cell through AKT (show AKT1 Proteins)/GSK3beta/beta-catenin (show CTNNB1 Proteins) signaling.
IGFBP7 down-regulation is associated with poor prognosis in glioma, and this molecule may represent both a prognostic marker and a potential therapeutic target.
Our data indicate that IGFBP7 expression is a marker for a specific methylation pattern in myeloma
The low levels of IGFBP7 in high-grade serous ovarian carcinoma are associated with survival rate.
Overexpression of IGFBP7 was associated with tumour progression and poor survival in gastric cancer. IGFBP7 may play a role in tumour progression in gastric cancer.
we demonstrated that IGFBP-rP1 suppresses EMT (show ITK Proteins) and tumor metastasis by repressing TGF-b-mediated EMT (show ITK Proteins) through the Smad (show SMAD1 Proteins) signaling cascade.
data suggest that IGFBP-7 was up regulated during EAE and inhibit the transition from OPCs to mature OLs, implying its use as a potential therapeutic target for the treatment of inflammatory demyelinating diseases
Our data suggest that loss of Igfbp7 induces precocious involution possibly through diminished cell survival signals.
Angiomodulin is necessary for cardiac commitment of embryonic stem cells (ESCs (show NR2E3 Proteins)) and its regulation depends on TAp63 isoform.
results show that Smarcb1 (show SMARCB1 Proteins) is required for transcriptional activation of Igfbp7 and show that re-introduction of Igfbp7 alone can hinder tumor development; results define a novel mechanism for Smarcb1 (show SMARCB1 Proteins)-mediated tumorigenesis
a model whereby IGFBP7 binds to unoccupied IGF1R (show IGF1R Proteins) and suppresses downstream signaling, thereby inhibiting protein synthesis, cell growth, and survival.
IGFBP7 has a novel role in mouse uterus: it is regulating uterine receptivity through Th1 (show HAND1 Proteins)/Th2 lymphocyte balance and decidualization.
fear extinction-induced IGF2/IGFBP7 signalling promotes the survival of 17-19-day-old newborn hippocampal neurons
Results demonstrate that the vascular-specific marker angiomodulin (AGM) modulates vascular remodeling in part by temporizing the proangiogenic effects of VEGF-A (show VEGFA Proteins).
study showed that IGFBP-rP1 (IGFBP7) was expressed in dysregulated podocytes in a human immunodeficiency virus-associated nephropathy model and in immature podocytes in the developing kidney; conclude that IGFBP-rP1 may be a product of injured podocytes
inhibition of Malignant melanoma growth is due to apoptosis and reduced expression of VEGF (show VEGFA Proteins) induced by pEGFC1-IGFBP7
This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307).
insulin-like growth factor-binding protein 7
, IGF-binding protein 7
, PGI2-stimulating factor
, prostacyclin-stimulating factor
, tumor-derived adhesion factor