Insulin-Like Growth Factor Binding Protein, Acid Labile Subunit Proteins (IGFALS)

The protein encoded by IGFALS is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Additionally we are shipping Insulin-Like Growth Factor Binding Protein, Acid Labile Subunit Antibodies (67) and Insulin-Like Growth Factor Binding Protein, Acid Labile Subunit Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IGFALS 3483 P35858
IGFALS 16005 P70389
IGFALS 79438 P35859
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Top Insulin-Like Growth Factor Binding Protein, Acid Labile Subunit Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$740.00
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Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,666.67
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IGFALS Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Insulin-Like Growth Factor Binding Protein, Acid Labile Subunit (IGFALS) Interaction Partners

Human Insulin-Like Growth Factor Binding Protein, Acid Labile Subunit (IGFALS) interaction partners

  1. The aim of this study was to evaluate the potential pathogenicity of eleven IGFALS variants.

  2. Previously characterized disease-causing mutations in IGF2, IGF1R (show IGF1R Proteins), IGF2R (show IGF2R Proteins), or IGFALS all were found in the general population but with allele frequencies of <1:30,000.

  3. To the known phenotype of ACLSD (i.e. short stature, reduced serum levels of IGF-I and ALS, extremely low serum IGFBP-3 and disturbed ternary complex formation), the study adds reduced birth weight, head circumference and serum IGF-II.

  4. Mutations in the IGFALS and low expression level of IGFALS proteins lead to growth and development retardation. [Review]

  5. A novel homozygous mutation in IGFALS, c.380T>C (p.L127P), was identified in two siblings of a consanguineous family.

  6. Heterozygous IGFALS gene variants could be responsible for short stature in a subset of idiopathic short stature children with diminished levels of IGF-1, IGFBP-3 and ALS.

  7. These gene dosage effects demonstrate that one functional IGFALS allele is insufficient to maintain normal ALS levels, endocrine IGF-I (show IGF1 Proteins) action, full growth potential, muscle size, and periosteal expansion.

  8. functional analysis supported a tumor-suppressive function for IGFALS in vitro.

  9. Heterozygous STAT5B mutations, with or without heterozygous IGFALS defects, may be associated with growth hormone insensitivity.

  10. low circulating IGF-I (show IGF1 Proteins) levels due to Acid-Labile Subunit deficiency in adulthood are not associated with early development of atherosclerosis and impaired heart function.

Mouse (Murine) Insulin-Like Growth Factor Binding Protein, Acid Labile Subunit (IGFALS) interaction partners

  1. the Igfals gene has a role in skeletal response of male mice to anabolic hormone therapy

  2. A modest reduction in post-natal growth in the null ALS mice and in the ALS-deficient patients was observed

Pig (Porcine) Insulin-Like Growth Factor Binding Protein, Acid Labile Subunit (IGFALS) interaction partners

  1. The isolation and characterization of the IGFALS gene, including its expression profile and variations, are reported.

Cow (Bovine) Insulin-Like Growth Factor Binding Protein, Acid Labile Subunit (IGFALS) interaction partners

  1. Polymorphisms in the IGFALS gene are associated with growth traits in beef cattle (Bos taurus) in China.

Insulin-Like Growth Factor Binding Protein, Acid Labile Subunit (IGFALS) Protein Profile

Protein Summary

The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene.

Gene names and symbols associated with IGFALS

  • insulin like growth factor binding protein acid labile subunit (IGFALS)
  • insulin like growth factor binding protein acid labile subunit L homeolog (igfals.L)
  • insulin-like growth factor binding protein, acid labile subunit (Igfals)
  • Albs protein
  • Als protein
  • mKIAA4111 protein

Protein level used designations for IGFALS

insulin-like growth factor binding protein, acid labile subunit , insulin-like growth factor-binding protein complex acid labile subunit-like , insulin-like growth factor binding protein complex acid labile chain , insulin-like growth factor-binding protein complex acid labile subunit , insulin-like growth factor binding protein complex acid-labile subunit , insulin-like growth factor-binding protein complex acid labile chain , insulin-like growth factor binding protein, acid-labile subunit

GENE ID SPECIES
467869 Pan troglodytes
490069 Canis lupus familiaris
100101314 Xenopus laevis
100414686 Callithrix jacchus
3483 Homo sapiens
16005 Mus musculus
79438 Rattus norvegicus
397322 Sus scrofa
532494 Bos taurus
427649 Gallus gallus
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