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Integrin Alpha2b Proteins (CD41)

ITGA2B encodes integrin alpha chain 2b. Additionally we are shipping Integrin Alpha2b Antibodies (517) and Integrin Alpha2b Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CD41 16399 Q9QUM0
CD41 3674 P08514
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Top Integrin Alpha2b Proteins at antibodies-online.com

Showing 6 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag   10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CD41 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , , ,
, ,

More Proteins for Integrin Alpha2b (CD41) Interaction Partners

Mouse (Murine) Integrin Alpha2b (CD41) interaction partners

  1. ITGA2b expression increases in response to immunization, raising the possibility that heterogeneous ITGA2b levels reflect variation in exposure to activation signals.

  2. Thrombopoietin (show THPO Proteins)/MPL (show MPL Proteins) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 (show MECOM Proteins) leukemia.

  3. Direct binding of kindlin-3 (show FERMT3 Proteins) to integrin alphaIIbbeta3 is involved in supporting integrin alphaIIbbeta3 activation and integrin alphaIIbbeta3-dependent responses of platelets and consequently contributes significantly to arterial thrombus formation.

  4. ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding.

  5. reduction of talin-beta3 integrin (show ITGB3 Proteins) binding affinity results in decelerated alphaIIbbeta3 integrin activation and protection from arterial thrombosis without pathological bleeding

  6. deficiency of Dok-2 leads to dysregulated integrin alphaIIbbeta3-dependent cytosolic calcium flux and phosphatidylinositol(3,4)P2 accumulation.

  7. Platelets lacking ERp57 (show PDIA3 Proteins) have defective activation of the alphaIIbbeta3 integrin and platelet aggregation. The defect in aggregation was corrected by the addition of exogenous ERp57 (show PDIA3 Proteins), implicating surface ERp57 (show PDIA3 Proteins) in platelet aggregation.

  8. Data indicate that Pyk2 (show PTK2B Proteins) is a common signaling effector downstream of both G12 (show TCF3 Proteins)/13 and integrin alphaIIbbeta3 signaling, which contributes to thromboxane generation.

  9. These results identify a novel pathway of integrin alphaIIbbeta3 outside-in signaling and recognize the tyrosine kinase Pyk2 as a major regulator of platelet adhesion and spreading on fibrinogen.

  10. identified Hic-5 (show TGFB1I1 Proteins) as a novel and specific regulatory factor for thrombin (show F2 Proteins)-induced alphaIIbbeta3 activation and subsequent platelet aggregation in mice.

Human Integrin Alpha2b (CD41) interaction partners

  1. This study shows correlation of blood clot stiffness with platelet integrin alpha-IIb beta3 activity, aspirin usage, and transfusion risk in cardiopulmonary bypass patients.

  2. Data show that immune thrombocytopenia (ITP (show ITPA Proteins)) is an autoimmune bleeding disorder characterized by low platelet count and presence of IgG autoantibodies to platelet surface glycoproteins, such as alpha IIbbeta3 integrins.

  3. Data suggest that the ligand AGDV tetrapeptide binds to ITGB3/GPIIIa subunit and induces complete opening of headpiece of integrin alphaIIb/beta3 complex; AGDV appears to have very little contact with ITGA2B/GPIIb subunit.

  4. Analysis showed a protective effect of TT genotype of ITGA2 (show ITGA2 Proteins) 807 C/T on fibrosis progression rate in Chronic Hepatitis C patients.

  5. Report novel ITGA2B mutations causing Glanzmann thrombasthenia.

  6. Ibrutinib causes GPVI (show GP6 Proteins) and integrin alphaIIbbeta3 platelet signaling deficiencies that result in formation of unstable thrombi and may contribute toward bleeding.

  7. Data indicate 114 novel missense variants in integrin alpha 2b (ITGA2B) and 68 novel missense variants in integrin beta 3 (ITGB3 (show ITGB3 Proteins)).

  8. Data (including data from molecular dynamic simulations) suggest specific interactions between glycoprotein GPIIb/GPIIIa (show ITGB3 Proteins) complex transmembrane/C-terminal domains and talin-1 (show TLN1 Proteins) in cell membrane environment during platelet activation.

  9. Anionic lipids in annular positions stabilize the alphaIIbbeta3 transmembrane complex by up to 0.50 +/- 0.02 kcal/mol (show DUOXA1 Proteins) relative to zwitterionic lipids in a headgroup structure-dependent manner.

  10. ITGA2B rs5911 GG genotype is associated with decreased ex vivo antiplatelet activity of ticagrelor in healthy Chinese male subjects.

Integrin Alpha2b (CD41) Protein Profile

Protein Summary

ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Gene names and symbols associated with Integrin Alpha2b Proteins (CD41)

  • integrin alpha 2b (Itga2b)
  • integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) (ITGA2B)
  • AI172977 protein
  • alphaIIb protein
  • BDPLT2 protein
  • BDPLT16 protein
  • CD41 protein
  • CD41B protein
  • GP2B protein
  • GPIIb protein
  • GT protein
  • GTA protein
  • HPA3 protein

Protein level used designations for Integrin Alpha2b Proteins (CD41)

GP IIb , GPalpha IIb , alpha IIb , integrin alpha-IIb , platelet glycoprotein IIb of IIb/II Ia complex , platelet membrane glycoprotein IIb , platelet fibrinogen receptor, alpha subunit , platelet-specific antigen BAK

GENE ID SPECIES
16399 Mus musculus
3674 Homo sapiens
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