Integrin Alpha2b Protein (CD41) (AA 639-887, partial) (His-SUMO Tag)

Catalog No. ABIN5709771

This Recombinant Integrin Alpha2b protein is expressed in Escherichia coli (E. coli).

Quick Overview for Integrin Alpha2b Protein (CD41) (AA 639-887, partial) (His-SUMO Tag) (ABIN5709771)

Target: Integrin Alpha2b (CD41)

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Purity: > 90 %

Product Details

Protein Characteristics: AA 639-887, partial

Purification tag / Conjugate: This Integrin Alpha2b protein is labelled with His-SUMO Tag.

Sequence: CVPQLQLTAS VTGSPLLVGA DNVLELQMDA ANEGEGAYEA ELAVHLPQGA HYMRALSNVE GFERLICNQK KENETRVVLC ELGNPMKKNA QIGIAMLVSV GNLEEAGESV SFQLQIRSKN SQNPNSKIVL LDVPVRAEAQ VELRGNSFPA SLVVAAEEGE REQNSLDSWG PKVEHTYELH NNGPGTVNGL HLSIHLPGQS QPSDLLYILD IQPQGGLQCF PQPPVNPLKV DWGLPIPSPS PIHPAHHKR

Purification: SDS-PAGE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: Integrin Alpha2b (CD41)

Alternative Name: ITA2B

Background: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

Molecular Weight: 42.97 kDa

UniProt: P08514

Pathways: Integrin Complex