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Integrin alpha 4 Proteins (ITGA4)

The product of ITGA4 belongs to the integrin alpha chain family of proteins. Additionally we are shipping Integrin alpha 4 Antibodies (86) and Integrin alpha 4 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse ITGA4 ITGA4 16401 Q00651
Rat ITGA4 ITGA4 311144  
ITGA4 3676 P13612
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Top Integrin alpha 4 Proteins at

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 0.05 mg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) General Un-conjugated 0.05 mg Log in to see 6 to 11 Days

ITGA4 Proteins by Origin and Source

Origin Expressed in Conjugate

More Proteins for Integrin alpha 4 (ITGA4) Interaction Partners

Rhesus Monkey Integrin alpha 4 (ITGA4) interaction partners

  1. Administration of a novel recombinant antibody against alpha4beta7 gut (show GUSB Proteins)-homing integrin during acute lentiviral infection prevents mobilization of cell lineages of the innate immune system and protects the gut (show GUSB Proteins) tissues from acute lentiviral infection.

Mouse (Murine) Integrin alpha 4 (ITGA4) interaction partners

  1. These results suggest that Tie2 (show TEK Proteins) signaling induces alpha4beta1 integrin activation on bone marrow-mast cell progenitor for adhesion to VCAM-1 (show VCAM1 Proteins).

  2. ITGA4 expression enhances metastasis in MYCN (show MYCN Proteins) low neuroblastoma (show ARHGEF16 Proteins).

  3. CD49d-high-expressing Th1 (show HAND1 Proteins) memory phenotype CD4 (show CD4 Proteins)+ T cells with enhanced B cell helper activity develop early in the peritoneal cavity.

  4. Data suggest that bortezomib mobilizes hematopoietic stem cells (HSPCs) by modulation of the integrin alpha4beta1 (VLA)-4/vascular cell adhesion molecule-1 (VCAM-1 (show VCAM1 Proteins)) axis.

  5. Consistent with a role of alpha4beta7 in the generation of intestinal mononuclear phagocytes, bone marrow cells from beta7(-/-) mice poorly reconstituted small intestine retinoic acid (RA)-producing CD11c (show ITGAX Proteins)(hi) dendritic cells.

  6. SP/drug efflux functionality of hematopoietic progenitors is controlled by mesenchymal niche through VLA-4/CD44 (show CD44 Proteins) axis.

  7. We conclude that integrin alpha4beta1 is necessary for CD4 (show CD4 Proteins)(+) T cell-mediated protection against C. trachomatis infection in the genital mucosa.

  8. Mobilization of bone marrow-derived cells by G-CSF (show CSF3 Proteins) boosted migration along the VCAM-1 (show VCAM1 Proteins)/VLA-4 axis and reduced apoptosis of cardiomyocytes.

  9. PI3-kinase gamma (show PIK3CG Proteins) promotes Rap1a (show RAP1A Proteins)-mediated activation of myeloid cell integrin alpha4beta1, leading to tumor inflammation and growth.

  10. alpha(4) and alpha(9) integrins interacting with OPN (show SPP1 Proteins) via the SLAYGLR domain play a key role in macrophage biology by regulating migration, survival, and accumulation.

Human Integrin alpha 4 (ITGA4) interaction partners

  1. Enhanced susceptibility of activated endocervical CD4+ T cells to HIV may be related to increased CCR5 expression by these cell subsets, but did not appear to be due to direct interaction of integrins a4b7 or a4b1 with HIV envelope.

  2. knockdown of PTTG1 (show PTTG1 Proteins) increased expression of integrin alpha 4 (ITGA4), ITGA5 (show ITGA5 Proteins), and integrin beta 1 (ITGB1 (show ITGB1 Proteins)); otherwise, RhoA (show RHOA Proteins) expression was significantly decreased

  3. Integrin alpha 2 (show ITGA2 Proteins) and alpha 4 Yxxphi motifs interact with the endocytic clathrin adaptor, AP2 complex (show AP2B1 Proteins).

  4. ITGA4 expression enhances metastasis in MYCN (show MYCN Proteins) low neuroblastoma (show ARHGEF16 Proteins).

  5. Data show that a small molecule inhibitor of the MYC (show MYC Proteins) transcription factor can be an effective anticancer agent when delivered using a integrin alphavbeta3 (show ITGAV Proteins) and VLA-4-targeted nanotherapy approach.

  6. Collectively, these data suggest a role for alpha4beta7 integrin in HIV infection that is influenced by both viral and host factors including the sequence of the HIV gp120 (show ITIH4 Proteins) alpha4beta7 binding motif, the cytokine milieu and bacterial vaginosis in the genital tract.

  7. CD49d and CD26 (show DPP4 Proteins) have independent prognostic value and we suggest its use as a part of routine panel for prognostic stratification of CLL.

  8. Hypermethylation of ITGA4 promoter is increased in inflamed colon tissue.

  9. Regulatory CD4 (show CD4 Proteins) T cells (Treg) cells in co-infected patients present phenotypic alterations and might have dysfunction marked by low expression of Foxp3 (show FOXP3 Proteins) and increased expression of molecules not frequently seen on Treg cells, such as CD49d.

  10. High VLA-4 expression was independently associated with a high probability of complete remission in acute myeloid leukemia (show BCL11A Proteins) patients.

Integrin alpha 4 (ITGA4) Protein Profile

Protein Summary

The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.

Gene names and symbols associated with Integrin alpha 4 Proteins (ITGA4)

  • integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) (ITGA4)
  • integrin alpha 4 (Itga4)
  • integrin, alpha 4 (Itga4)
  • integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) (itga4)
  • CD49D protein
  • IA4 protein

Protein level used designations for Integrin alpha 4 Proteins (ITGA4)

integrin alpha 4 , CD49 antigen-like family member D , LPAM subunit alpha , VLA-4 receptor, alpha 4 subunit , VLA-4 subunit alpha , integrin alpha-4 , integrin alpha-IV , lymphocyte Peyer patch adhesion molecules subunit alpha , 269C wild type , antigen CD49D, alpha-4 subunit of VLA-4 receptor , integrin alpha-4 subunit , very late activation protein 4 receptor, alpha 4 subunit

470596 Pan troglodytes
704745 Macaca mulatta
16401 Mus musculus
311144 Rattus norvegicus
3676 Homo sapiens
397839 Xenopus laevis
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