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May play a role during maturation and/or organization of muscles cells (By similarity). Additionally we are shipping Integrin beta 1 Binding Protein (Melusin) 2 Antibodies (48) and Integrin beta 1 Binding Protein (Melusin) 2 Kits (4) and many more products for this protein.
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Chp-1 (show CHP Proteins) and melusin can interact with cochaperones PP5 (show PPP5C Proteins) and Sgt1 (show SUGT1 Proteins) and with each other in an ATP-dependent manner
Identification of a missense mutation in the melusin-encoding ITGB1BP2 gene in a patient with dilated cardiomyopathy
The altered melusin pathways and CDC42 (show CDC42 Proteins) parallel the cardiac function progression during cardiac remodeling post-MI.
Our analysis revealed an extremely low number of variations in the ITGB1BP2 gene in nearly 1000 hypertensive/cardiopathic and healthy individuals, thus suggesting a high degree of conservation of the melusin gene within the populations analyzed
Findings implicate melusin as an enhancer of AKT (show AKT1 Proteins) and ERK (show EPHB2 Proteins) pathways and as a novel player in cardioprotection from ischemia-reperfusion injury.
Multiple hypertrophic stimuli regulate melusin expression predominately in the atria, which may represent a necessary initial step in early adaptive remodelling processes in left ventricular hypertrophy.
Chp-1 (show CHORDC1 Proteins) and melusin can interact with cochaperones PP5 (show PPP5C Proteins) and Sgt1 (show SUGT1 Proteins) and with each other in an ATP-dependent manner
controls ERK1/2 activation in heart
PI3K regulates the expression of genes essential for cardiac structure and Z-disc signaling, interacts with melusin, and is critical for Z-disc alignment
Data show that melusin prevents cardiac dilation during chronic pressure overload by specifically sensing mechanical stress.
Melusin directly binds to Hsp90 (show HSP90 Proteins), a ubiquitous chaperone involved in regulating several signaling pathways.
May play a role during maturation and/or organization of muscles cells (By similarity).
integrin beta-1-binding protein 2