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IFI16 encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. Additionally we are shipping IFI16 Kits (13) and IFI16 Proteins (7) and many more products for this protein.
Showing 10 out of 87 products:
Human Monoclonal IFI16 Primary Antibody for IF, WB - ABIN393907
Johnatty, Beesley, Chen, Macgregor, Duffy, Spurdle, deFazio, Gava, Webb, Rossing, Doherty, Goodman, Lurie, Thompson, Wilkens, Ness, Moysich, Chang-Claude, Wang-Gohrke, Cramer, Terry, Hankinson, Tworoger, Garcia-Closas, Yang, Lissowska, Chanock, Pharoah, S: Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". in PLoS genetics 2010
Show all 5 references for ABIN393907
Human Polyclonal IFI16 Primary Antibody for ELISA, WB - ABIN1534925
Trapani, Browne, Dawson, Ramsay, Eddy, Show, White, Dupont: A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells. in Immunogenetics 1992
Show all 2 references for ABIN1534925
Human Monoclonal IFI16 Primary Antibody for IHC (p), ELISA - ABIN516822
Anthonio, Brees, Baumgart-Vogt, Hongu, Huybrechts, Van Dijck, Mannaerts, Kanaho, Van Veldhoven, Fransen: Small G proteins in peroxisome biogenesis: the potential involvement of ADP-ribosylation factor 6. in BMC cell biology 2009
p204 initiated innate antiviral responses in adipose cells, thereby modulating adipocyte function.
cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection.
The present study demonstrated that mouse Leydig cells had innate antiviral activities in response to viral DNA challenge through p204 activation.
Data indicate that the transient expression of p204 in the early stage is indispensable for adipocyte differentiation. Disruption of p204 expression patterns at this stage leads to irreversible damage in fat formation.
IFI16 exerts in vivo anti-tumoral activity by promoting apoptosis of tumor cells.
This gene product interacts with the Tpr protein, a component of the nuclear pore complex.
expression of p204 is activated by the cardiac Gata4 (show GATA4 Antibodies), Nkx2.5 (show NKX2-5 Antibodies), and Tbx5 (show TBX5 Antibodies) proteins
binding of Id1 (show ID1 Antibodies), Id2, or Id3 (show ID3 Antibodies) protein to the Gata4 (show GATA4 Antibodies) and Nkx2.5 (show NKX2-5 Antibodies) proteins inhibits the p204-induced differentiation of P19 (show CDKN2D Antibodies) cells to myocytes
p204 synergizes with pRb (show PGR Antibodies) in the stimulation of Cbfa1 (show RUNX2 Antibodies)-dependent gene activation and osteoblast differentiation
Ifi204 is a regulator of monocyte/macrophage differentiation and make possible a connection with other myeloid regulators [review]
By combining biochemical assays and single-molecule techniques, the authors show that the nuclear innate immune sensor IFI16 one-dimensionally tracks long stretches of exposed foreign dsDNA to assemble into supramolecular signaling platforms.
High levels of circulating IFI16 in rheumatoid arthritis are more frequent in RF/anti-CCP (show CRYGD Antibodies)-positive RA patients and significantly associated with pulmonary involvement.
A significant upregulation of the PYHIN inflammasomes AIM2 (show AIM2 Antibodies) and IFI16 in active inflammatory bowel disease versus controls was found.
Results provide mechanistic insights into the regulation of IFI16 during HSV-1 infection and show interactions with ICP0 and PML (show PML Antibodies)-containing ND10 bodies that can contribute to IFI16 antiviral functions.
Studies of the dynamics of the response of PML (show PML Antibodies) nuclear body components and IFI16 to invading herpes simplex virus 1 genomes demonstrated that human Daxx (hDaxx (show DAXX Antibodies)) and IFI16 respond more rapidly than PML (show PML Antibodies).
These findings demonstrate that IFI16 plays a critical role in fms-like tyrosine kinase 1 (show FLT1 Antibodies) and soluble endoglin (show ENG Antibodies) production in human trophoblast cells.
IFI16 sera concentration was directly correlated with disease duration and inversely correlated with age at diagnosis of Sjogren's syndrome.
increased nuclear acetylation of IFI16 is a dynamic essential post-genome recognition event in the nucleus that is common to the IFI16-mediated innate responses of inflammasome induction and IFN-beta (show IFNB1 Antibodies) production during herpesvirus infections
BRCA1 is a constituent of the triggered IFI16-inflammasome and is translocated into the cytoplasm after genome recognition along with the IFI16-inflammasome
IFI16 gene expression directly correlated with NF-kappaB (show NFKB1 Antibodies) activation, indicating that IFI16 could be considered an upstream modulator of NF-kappaB (show NFKB1 Antibodies) in human B-cells.
This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
interferon, gamma-inducible protein 16
, interferon, gamma-inducible gene 204
, interferon-activable protein 204
, interferon-inducible protein p204
, gamma-interferon-inducible protein 16
, interferon-gamma induced protein IFI 16
, interferon-inducible myeloid differentiation transcriptional activator
, interferon activated gene 203
, Gamma-interferon-inducible protein Ifi-16