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IFI16 antibody (C-Term)

IFI16 Reactivity: Human WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6257606
  • Target See all IFI16 Antibodies
    IFI16 (Interferon, gamma-Inducible Protein 16 (IFI16))
    Binding Specificity
    • 15
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 35
    • 3
    • 1
    Human
    Host
    • 31
    • 4
    Rabbit
    Clonality
    • 33
    • 2
    Polyclonal
    Conjugate
    • 20
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IFI16 antibody is un-conjugated
    Application
    • 35
    • 13
    • 13
    • 12
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    IFI16 Antibody detects endogenous levels of total IFI16.
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human IFI16, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product IFI16 Primary Antibody
  • Application Notes
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    IFI16 (Interferon, gamma-Inducible Protein 16 (IFI16))
    Alternative Name
    IFI16 (IFI16 Products)
    Synonyms
    IFNGIP1 antibody, PYHIN2 antibody, IFI16 antibody, Ifitm3l antibody, Ifitml antibody, interferon gamma inducible protein 16 antibody, interferon induced transmembrane protein 2 antibody, myeloid cell nuclear differentiation antigen-like protein antibody, interferon-activable protein 203 antibody, IFI16 antibody, Ifitm2 antibody, LOC100156073 antibody, LOC488622 antibody, Ifi16 antibody
    Background

    Description: Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

    Gene: IFI16

    Molecular Weight
    88 kDa
    Gene ID
    3428
    UniProt
    Q16666
    Pathways
    Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Autophagy, Inflammasome
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