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IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. Additionally we are shipping Interferon Regulatory Factor 2 Antibodies (125) and Interferon Regulatory Factor 2 Proteins (19) and many more products for this protein.
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It might play as a tumor suppressor by regulating P53 (show TP53 ELISA Kits) signaling in gastric cancer.
the association of IRF2 with susceptibility to systemic lupus erythematosus
Data suggest that interferon (show IFNA ELISA Kits) regulatory factors 1 and 2 (IRF1 (show IRF1 ELISA Kits) and IRF2) may serve as potential targets of therapy.
miR (show MLXIP ELISA Kits)-221 directly inhibits the expression of SOCS3 (show SOCS3 ELISA Kits) and IRF2.
KGF (show FGF7 ELISA Kits) could up-regulate IL-7 (show IL7 ELISA Kits) expression through the STAT1 (show STAT1 ELISA Kits)/IRF-1 (show IRF1 ELISA Kits), IRF-2 signaling pathway, which is a new insight in potential effects of KGF (show FGF7 ELISA Kits) on the intestinal mucosal immune system.
IFN regulatory factor 2 (Irf2) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3 (show SPINK1 ELISA Kits)
IRF2 overexpression protects against I/R injury by decreasing IRF1 (show IRF1 ELISA Kits)-dependent injury and may represent a novel therapeutic strategy.
The results suggested that distinct markers in IRF2 may be associated with atopic dermatitis and eczema herpeticum (which may depend upon ethnic ancestry) and genetic variants in IRF2 may contribute to an abnormal immune response to herpes simplex virus.
these results suggest that IRF-2 plays an important role in the tumorigenesis of pancreatic cancer and down-regulation of IRF-2 would be a new treatment target for pancreatic cancer.
IRF-2 activates the HPV-16 P97 (show EIF4G2 ELISA Kits) promoter in vivo.
Chimeric IRF-2 binds with IRF (show TRIM63 ELISA Kits)-E motif and VREbeta but not with VREalpha1.
IFN regulatory factor 2 (Irf2) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3 (show SPINK3 ELISA Kits)
These results revealed a multi-faceted role of IRF-2 in the function of B cells, particularly B2 cells, through regulating proliferation in an IFNAR (show IFNAR1 ELISA Kits)-dependent manner and antibody production via up-regulation of Blimp-1 (show PRDM1 ELISA Kits).
In mice doubly deficient forIRF-2 and CD1d (show CD1D ELISA Kits), the overall memory phenotype T cell population is contrastingly enlarged.
IRF2 regulates exocytosis in pancreatic acinar cells; defects in this process might be involved in the early phases of acute pancreatitis.
Forced expression of the interferon regulatory factor 2 oncoprotein causes polyploidy and cell death in FDC-P1 myeloid hematopoietic progenitor cells.
Irf2 has an important role in vitro in the regulation of COX-2 (show COX2 ELISA Kits) expression by LPS (show TLR4 ELISA Kits).
IRF-2 is acetylated in a cell growth-dependent manner, which enables it to contribute to transcription of cell growth-regulated promoters
IRF-2 is a critical transacting factor that regulates in vivo responses to lipopolysaccharide, with a novel anti-apoptotic role.
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.
regulatory factor 2
, interferon responsive factor 2
, interferon regulatory factor 2b