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IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. Additionally we are shipping Interferon Regulatory Factor 2 Antibodies (139) and Interferon Regulatory Factor 2 Proteins (19) and many more products for this protein.
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In a genome wide are study to identify acute kidney injury risk in critically ill patients, the locus on chromosome 4, located 150 kb upstream of IRF2 was identified to regulate immunity pathways related to kidney disease risk gene APOL1 (show APOL1 ELISA Kits). Disruption of IRF-2 has been found to up-regulate the inflammatory response to infection.
Study shows that IRF2 knockdown inhibits growth, colony formation of OCI/AML-2 (show RUNX3 ELISA Kits), OCI/AML-3 (show RUNX2 ELISA Kits), and THP-1 (show GLI2 ELISA Kits) cells. In addition, IRF2 knockdown induces apoptosis of acute myeloid leukemia (show BCL11A ELISA Kits) (AML (show RUNX1 ELISA Kits)) cells by regulating apoptotic effectors. Further mechanism analysis shows that INPP4B (show INPP4B ELISA Kits) contributes to the effects of IRF2 on apoptosis and growth of AML (show RUNX1 ELISA Kits) cells. Thus, IRF2 serves as an important regulator in AML (show RUNX1 ELISA Kits) by targeting INPP4B (show INPP4B ELISA Kits).
miR (show MLXIP ELISA Kits)-450 targets IRF2 and thus supresses lung cancer cell proliferation and invasion.
It might play as a tumor suppressor by regulating P53 (show TP53 ELISA Kits) signaling in gastric cancer.
the association of IRF2 with susceptibility to systemic lupus erythematosus
Data suggest that interferon (show IFNA ELISA Kits) regulatory factors 1 and 2 (IRF1 (show IRF1 ELISA Kits) and IRF2) may serve as potential targets of therapy.
miR (show MLXIP ELISA Kits)-221 directly inhibits the expression of SOCS3 (show SOCS3 ELISA Kits) and IRF2.
KGF (show FGF7 ELISA Kits) could up-regulate IL-7 (show IL7 ELISA Kits) expression through the STAT1 (show STAT1 ELISA Kits)/IRF-1 (show IRF1 ELISA Kits), IRF-2 signaling pathway, which is a new insight in potential effects of KGF (show FGF7 ELISA Kits) on the intestinal mucosal immune system.
IFN regulatory factor 2 (Irf2) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3 (show SPINK1 ELISA Kits)
IRF2 overexpression protects against I/R injury by decreasing IRF1 (show IRF1 ELISA Kits)-dependent injury and may represent a novel therapeutic strategy.
Mysm1 enhanced function of the IRF2 and IRF8 promoters, suggesting that Mysm1 governs the IRFs for hematopoietic stem cell homeostasis.
Interferon regulatory factor 2 protects mice from lethal viral neuroinvasion
Chimeric IRF-2 binds with IRF (show TRIM63 ELISA Kits)-E motif and VREbeta but not with VREalpha1.
IFN regulatory factor 2 (Irf2) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3 (show SPINK3 ELISA Kits)
These results revealed a multi-faceted role of IRF-2 in the function of B cells, particularly B2 cells, through regulating proliferation in an IFNAR (show IFNAR1 ELISA Kits)-dependent manner and antibody production via up-regulation of Blimp-1 (show PRDM1 ELISA Kits).
In mice doubly deficient forIRF-2 and CD1d (show CD1D ELISA Kits), the overall memory phenotype T cell population is contrastingly enlarged.
IRF2 regulates exocytosis in pancreatic acinar cells; defects in this process might be involved in the early phases of acute pancreatitis.
Forced expression of the interferon regulatory factor 2 oncoprotein causes polyploidy and cell death in FDC-P1 myeloid hematopoietic progenitor cells.
Irf2 has an important role in vitro in the regulation of COX-2 (show COX2 ELISA Kits) expression by LPS (show TLR4 ELISA Kits).
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.
regulatory factor 2
, interferon responsive factor 2
, interferon regulatory factor 2b