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IFIT2 encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Additionally we are shipping Interferon-Induced Protein with Tetratricopeptide Repeats 2 Antibodies (61) and many more products for this protein.
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The results of the present study revealed that the inhibition of proteasome activity blocked the degradation of IFIT2 and promoted the aggregation of IFIT2 in the centrosome, which in turn induced cell apoptosis. In short, IFIT2 may be a potential target for cancer therapeutics.
Mechanistic investigations reveal that AJUBA (show AJUBA Proteins) specifically binds the FERM domain of JAK1 (show JAK1 Proteins) to dissociate JAK1 (show JAK1 Proteins) from the IFNgamma recepter, resulting in an inhibition of STAT1 (show STAT1 Proteins) phosporylation and concomitantly its nuclear translocation. Clinically, the level of AJUBA (show AJUBA Proteins) in CRC (show CALR Proteins) specimens is negatively correlated with the levels of IFIT2 and pSTAT1
LINC00161 is an essential regulator in cisplatin-induced apoptosis, and the LINC00161-miR (show MLXIP Proteins)-645-IFIT2 signalling axis plays an important role in reducing osteosarcoma chemoresistance.
there is a positive feedback loop between phosphorylated STAT1 and ISG56, ISG54 or ISG60.
Data show that interferon (show IFNA Proteins)-induced proteins with tetratricopeptide repeats 1 and 2 (IFIT1 (show IFIT1 Proteins) and IFIT2) contribute to the regulation of hepatitis B virus (HBV) replication, likely at both transcriptional and posttranscriptional steps.
Data shows that IFIT2 expression is downregulated in adenocarcinoma of gastric esophageal junction cells; its ectopic expression leads to cell apoptosis, suggesting its role as a tumor suppressor.
IFIT2, a protein responsible for interferon (show IFNA Proteins) stimulation, may prevent oral squamous cell carcinoma (OSCC) metastasis and serve as a valuable prognostic marker.
ISG54 binds specifically to some RNAs, such as adenylate uridylate (AU)-rich RNAs, with or without 5' triphosphorylation.
Inhibitor of kappaB kinase epsilon (IKK(epsilon (show IKBKE Proteins))), STAT1 (show STAT1 Proteins), and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection.
The expression of OASL (show OASL Proteins) and IFIT2 was significantly higher in SLE patients than in controls.
Ifit2 exerts its antiviral effect mainly at the level of viral replication, as opposed to functioning as a mechanism that restricts viral entry/egress or transports rabies virus particles through axons.
the mechanism for the observed differential induction of the mouse Ifit1 (show IFIT1 Proteins), Ifit2, and Ifit3 genes in B cells and demonstrated that the repressive effect of the transcription factor interferon regulatory factor 8 (IRF8 (show IRF8 Proteins)), which is highly expressed in B cells, played an essential role in this regulation.
These results indicate that high Sendai virus replication in the lungs of infected Ifit2(-/-) mice cooperates with elevated IFN-beta (show IFNB1 Proteins) induction to cause disease.
Ifit2 protects mice from infection of the peripheral nervous system by vesicular stomatitis virus.
Ifit2 is a positive regulator of IFN-alpha (show IFNA Proteins)/beta expression during mouse hepatitis virus induced encephalitis.
IFIT2 is an effector protein of type I IFN-mediated amplification of lipopolysaccharide (LPS (show TLR4 Proteins))-induced TNF-alpha (show TNF Proteins) secretion and LPS (show TLR4 Proteins)-induced endotoxin shock.
These results suggest that Ifit2 restricts West Nile virus infection and pathogenesis in different tissues in a cell type-specific manner.
results indicate that in the brain, but not in other organs, Ifit2 is a major mediator of IFN's protective effect against VSV
Our findings provide the first evidence of a differential pattern of expression of ISG54 and ISG56 (show IFIT1 Proteins) genes by IFN-alpha (show IFNA Proteins) and IFN-beta (show IFNB1 Proteins).
This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.
Interferon, alpha-inducible protein (MW 54kD)
, interferon-induced 54 kDa protein
, interferon-induced protein 54
, interferon-induced protein with tetratricopeptide repeats 2
, glucocorticoid-attenuated response gene 39 protein