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The protein encoded by IFITM3 is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Additionally we are shipping Interferon-Induced Transmembrane Protein 3 Antibodies (43) and Interferon-Induced Transmembrane Protein 3 Kits (7) and many more products for this protein.
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Human IFITM3 Protein expressed in Wheat germ - ABIN1307445
Yao, Dong, Zhu, Nelson, Liu, Lambiase, Li: Identification of the IFITM3 gene as an inhibitor of hepatitis C viral translation in a stable STAT1 cell line. in Journal of viral hepatitis 2011
Human IFITM3 Protein expressed in Human Cells - ABIN2005209
Tanaka, Yamaguchi, Tsoi, Lickert, Tam: IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. in Developmental cell 2005
Ifitm3 plays a role in mouse primordial germ cell homing and repulsion by enhancing the regionalization of PGCs.
Ifitm3 does not impact on the restriction or pathogenesis of bacterial (Salmonella typhimurium, Citrobacter rodentium, Mycobacterium tuberculosis) or protozoan (Plasmodium berghei) pathogens, despite in vitro evidence.
results suggest that modification of Tyr (show TYR Proteins)(20) may serve in a cellular checkpoint controlling IFITM3 trafficking and degradation and demonstrate the complexity of posttranslational regulation of IFITM3
Interferon-induced transmembrane protein 3 is a type II transmembrane protein (show SLC3A2 Proteins).
results revealed diverse, yet consistent, profiles of IFITM3 localization throughout the gastrula
Induction of IFITM3 expression in astrocytes leads to brain dysfunction by impairing neurite development and other non-cell autonomous effects such as increasing mRNA levels of inflammatory cytokines.
Jin Chai antiviral capsule exerts antiviral effects against influenza virus by raised expression of IFITM3.
lung TRM cells were programmed to retain IFITM3 expression, which facilitated their survival and protection from viral infection during subsequent exposures
A central role for Ifitm3 in limiting acute influenza in vivo.
IFITM3 is essential for defending the host against influenza A virus in vivo; mice lacking Ifitm3 display fulminant viral pneumonia when challenged with a normally low-pathogenicity influenza virus, mirroring the destruction inflicted by the highly pathogenic 1918 'Spanish' influenza
The present study identified the transcripts, which were affected by the downregulation of endogenous IFITM3 and the pathways they were involved in. These findings may lead to an improved understanding of the biological functions of IFITM3.
there is one transmembrane helix in the human IFITM3 with a possible role in virus entry
IFITM2 (show IFITM2 Proteins) and IFITM3 specifically antagonize the HIV-1 envelope glycoprotein (Env (show ERVW-1 Proteins)), thereby inhibiting viral infection.
we demonstrate that the E3 ubiquitin ligase (show MUL1 Proteins) NEDD4 (show NEDD4 Proteins) ubiquitinates IFITM3 in cells and in vitro.
Our meta-analysis suggests a significant association between a minor IFITM3 allele (SNP rs12252-C) with severe influenza susceptibility, but not in mild influenza subjects
A novel association between IFITM3 gene polymorphism and rapid disease progression is reported in an acute HIV-1-infected MSM cohort in China.
This meta-analysis suggests that IFITM3 rs12252 T>C polymorphism is significantly associated with increased risk of severe influenza but not with the chance of initial virus infection.
Incorporation of IFITM1 (show IFITM1 Proteins), IFITM2 (show IFITM2 Proteins) and IFITM3 into HIV-1 virions impair viral fusion and spread.
Authors suggest that IFITM3 adopts multiple membrane topologies involving at least one intramembrane domain in its antivirally active conformation.
Taken together, these data suggested that IFITM3 is a potential therapeutic target for GC.
The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined.
Interferon-induced transmembrane protein 3
, dispanin subfamily A member 2b
, fragilis protein
, ifitm-like protein 1
, interferon-induced transmembrane protein 3
, interferon-inducible protein 15
, interferon-inducible protein 1-8U
, interferon-inducible protein variant 10