Interferon-Induced Transmembrane Protein 3 Proteins (IFITM3)

The protein encoded by IFITM3 is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Additionally we are shipping Interferon-Induced Transmembrane Protein 3 Antibodies (48) and Interferon-Induced Transmembrane Protein 3 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IFITM3 66141 Q9CQW9
IFITM3 10410 Q01628
Rat IFITM3 IFITM3 361673 P26376
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Top Interferon-Induced Transmembrane Protein 3 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 20 to 21 Days
$272.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_Escherichia coli (E. coli) Human His-GST 10% SDS-PAGE stained with Coomassie Blue (CB) and peptide fingerprinting by MALDI-TOF mass spectrometry 50 μg Log in to see 6 to 9 Days
$317.63
Details

IFITM3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
, , ,

Top referenced Interferon-Induced Transmembrane Protein 3 Proteins

  1. Human IFITM3 Protein expressed in Wheat germ - ABIN1307445 : Yao, Dong, Zhu, Nelson, Liu, Lambiase, Li: Identification of the IFITM3 gene as an inhibitor of hepatitis C viral translation in a stable STAT1 cell line. in Journal of viral hepatitis 2011 (PubMed)

  2. Human IFITM3 Protein expressed in Human Cells - ABIN2005209 : Tanaka, Yamaguchi, Tsoi, Lickert, Tam: IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. in Developmental cell 2005 (PubMed)

More Proteins for Interferon-Induced Transmembrane Protein 3 (IFITM3) Interaction Partners

Mouse (Murine) Interferon-Induced Transmembrane Protein 3 (IFITM3) interaction partners

  1. IFITM1 (show IFITM1 Proteins) and IFITM3 inhibit Zika virus infection early in the viral life cycle.

  2. ZMPSTE24 (show Zmpste24 Proteins) is a downstream effector of IFITM3 and is important for interferon (show IFNA Proteins)-induced transmembrane antiviral activity.

  3. IFITM3 represents a checkpoint regulator of antiviral immunity that controls cytokine production to restrict viral pathogenesis.

  4. Collectively, the data define an antiviral role for Ifitm3 in restricting infection of multiple alphaviruses.

  5. Ifitm3 plays a role in mouse primordial germ cell homing and repulsion by enhancing the regionalization of PGCs.

  6. Ifitm3 does not impact on the restriction or pathogenesis of bacterial (Salmonella typhimurium, Citrobacter rodentium, Mycobacterium tuberculosis) or protozoan (Plasmodium berghei) pathogens, despite in vitro evidence.

  7. results suggest that modification of Tyr (show TYR Proteins)(20) may serve in a cellular checkpoint controlling IFITM3 trafficking and degradation and demonstrate the complexity of posttranslational regulation of IFITM3

  8. Interferon-induced transmembrane protein 3 is a type II transmembrane protein (show SLC3A2 Proteins).

  9. results revealed diverse, yet consistent, profiles of IFITM3 localization throughout the gastrula

  10. Induction of IFITM3 expression in astrocytes leads to brain dysfunction by impairing neurite development and other non-cell autonomous effects such as increasing mRNA levels of inflammatory cytokines.

Human Interferon-Induced Transmembrane Protein 3 (IFITM3) interaction partners

  1. IFITM1 (show IFITM1 Proteins) and IFITM3 inhibit Zika virus infection early in the viral life cycle.

  2. ZMPSTE24 (show Zmpste24 Proteins) is a downstream effector of IFITM3 and is important for interferon (show IFNA Proteins)-induced transmembrane antiviral activity.

  3. We failed to confirm an association between the rs12252_C allele of IFITM3 and influenza susceptibility in 2 cohorts of children.

  4. homozygous IFITM3 CC and TLR3 (show TLR3 Proteins) CC genotypes showed significant independent associations with higher death risks in H7N9/H1N1pdm09 influenza in a large Chinese cohort

  5. We found evidence of a new association of rs34481144 with severe influenza in three cohorts characterized by different levels of influenza illness severity. rs34481144 is an expression quantitative trait locus (eQTL (show EQTN Proteins)) for IFITM3, with the risk allele associated with lower mRNA expression. The risk allele was found to have decreased IRF3 (show IRF3 Proteins) binding and increased CTCF (show CTCF Proteins) binding in promoter-binding assays.

  6. IFITM3 rs12252 variant was associated with respiratory infection hospitalization but not specifically in patients infected with Influenza A(H1N1)pdm09.

  7. findings show that the sensitivity of influenza A viruses to the IFN-induced antiviral state and IFITM2 (show IFITM2 Proteins) and IFITM3 proteins depends on the pH value at which the viral HA undergoes a conformational transition and mediates membrane fusion

  8. cell-extrinsic and cell-intrinsic factors including IFITM3 have roles in regulating the efficiency and kinetics of virus entry and fusion with target cells

  9. Key features of the HIV-1 envelope protein that are associated with viral resistance to the IFITM3 protein.

  10. The study demonstrates that the human pulmonary endothelium possesses intrinsic immunity to human influenza viruses, in part due to the constitutive expression of IFITM3 proteins.

Interferon-Induced Transmembrane Protein 3 (IFITM3) Protein Profile

Protein Summary

The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined.

Gene names and symbols associated with IFITM3

  • Interferon-induced transmembrane protein 3 (ifm3)
  • interferon induced transmembrane protein 3 (Ifitm3)
  • interferon induced transmembrane protein 3 (IFITM3)
  • 1-8U protein
  • 1110004C05Rik protein
  • Cd225 protein
  • Cdw217 protein
  • DSPA2b protein
  • Fgls protein
  • IP15 protein
  • mil-1 protein
  • rat8 protein

Protein level used designations for IFITM3

Interferon-induced transmembrane protein 3 , dispanin subfamily A member 2b , fragilis protein , ifitm-like protein 1 , interferon-induced transmembrane protein 3 , interferon-inducible protein 15 , interferon-inducible protein 1-8U , interferon-inducible protein variant 10

GENE ID SPECIES
100305344 Oncorhynchus mykiss
66141 Mus musculus
10410 Homo sapiens
361673 Rattus norvegicus
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