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The protein encoded by IL10RA is a receptor for interleukin 10. Additionally we are shipping IL10RA Kits (21) and IL10RA Proteins (14) and many more products for this protein.
Showing 10 out of 208 products:
Mouse (Murine) Monoclonal IL10RA Primary Antibody for FACS - ABIN119864
Asseman, Mauze, Leach, Coffman, Powrie: An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. in The Journal of experimental medicine 1999
Show all 4 references for ABIN119864
Human Polyclonal IL10RA Primary Antibody for WB - ABIN616045
Okwor, Liu, Beverley, Uzonna: Inoculation of killed Leishmania major into immune mice rapidly disrupts immunity to a secondary challenge via IL-10-mediated process. in Proceedings of the National Academy of Sciences of the United States of America 2009
Show all 3 references for ABIN616045
Mouse (Murine) Monoclonal IL10RA Primary Antibody for FACS - ABIN119865
Sundstedt, ONeill, Nicolson, Wraith: Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivo. in Journal of immunology (Baltimore, Md. : 1950) 2003
Show all 3 references for ABIN119865
Human Monoclonal IL10RA Primary Antibody for FACS - ABIN119837
Liu, de Waal Malefyt, Briere, Parham, Bridon, Banchereau, Moore, Xu: The EBV IL-10 homologue is a selective agonist with impaired binding to the IL-10 receptor. in Journal of immunology (Baltimore, Md. : 1950) 1997
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Human Monoclonal IL10RA Primary Antibody for FACS, WB - ABIN4899662
Beck, Zobel, Barber, Evans, Lezina, Allchin, Blades, Elliott, Lord, Ashworth, Porter, Wagner: Synthetic Lethal Screen Demonstrates That a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA/JAK2/STAT3 Pathway in High Grade B-cell Lymphoma. in The Journal of biological chemistry 2016
Human Polyclonal IL10RA Primary Antibody for FACS, IF - ABIN652714
Jones, Logsdon, Josephson, Cook, Barry, Walter: Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1. in Proceedings of the National Academy of Sciences of the United States of America 2002
Human Polyclonal IL10RA Primary Antibody for ELISA, WB - ABIN1531662
Josephson, Logsdon, Walter: Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. in Immunity 2001
Human Polyclonal IL10RA Primary Antibody for WB - ABIN2782131
Gasche, Grundtner, Zwirn, Reinisch, Shaw, Zdanov, Sarma, Williams, Foxwell, Gangl: Novel variants of the IL-10 receptor 1 affect inhibition of monocyte TNF-alpha production. in Journal of immunology (Baltimore, Md. : 1950) 2003
a JAK2 (show JAK2 Antibodies) Inhibitor Suppresses a BCL6 (show BCL6 Antibodies)-dependent IL10RA/JAK2 (show JAK2 Antibodies)/STAT3 (show STAT3 Antibodies) Pathway in High Grade B-cell Lymphoma.
results suggest that IL10 (show IL10 Antibodies)-mediated inhibition of autophagy is facilitated by the cross talk between STAT3 (show STAT3 Antibodies), AKT (show AKT1 Antibodies), and mTOR (show FRAP1 Antibodies); in other words, the IL10 (show IL10 Antibodies)-IL10R-STAT3 (show STAT3 Antibodies) and IL10 (show IL10 Antibodies)-AKT (show AKT1 Antibodies)-mTOR (show FRAP1 Antibodies) pathways.
genetic association study in cohort of infants/children: Data suggest perianal fistulas are exhibited in patients with very early-onset inflammatory bowel disease with IL10 (show IL10 Antibodies) receptor mutations (IL10RA/B); prognosis and response to treatment are poor.
IL-10Ralpha expression is post-transcriptionally regulated by miR (show MLXIP Antibodies)-15a, miR (show MLXIP Antibodies)-185, and miR (show MLXIP Antibodies)-211 in melanoma
We also observed that BM-MSCs upregulated IL-10 (show IL10 Antibodies) secretion as well as the expression of its receptor CD210 on T cells, thus creating a loop favoring the expansion of IL-10 (show IL10 Antibodies)-producing T cells
SNP3 polymorphism is associated with myocardial infarction; may generate some conformational rearrangements of the IL-10R1 receptor domain which affects IL-10 (show IL10 Antibodies) complex binding and alters its downstream signal
High IL10RA expression is associated with diffuse large B-cell lymphoma.
Data suggest that, compared with monocytes and macrophages, myeloid dendritic cells partially escape from IL-10 (show IL10 Antibodies)'s inhibitory mechanisms by downregulating IL-10R1.
Inflammatory bowel disease (IBD) in infancy is phenotypically and genetically different disease entity from adult-onset or older child-onset IBD. It has a strong association with IL-10 (show IL10 Antibodies) receptor gene.
IL10R1 loss-of-function A536/S138G polymorphism may contribute to recurrent pregnancy loss pathogenesis
loss of IL-10R signaling impaired the generation and function of anti-inflammatory intestinal and bone-marrow-derived macrophages and their ability to secrete IL-10 (show IL10 Antibodies).
loss of IL-10 (show IL10 Antibodies) receptor expression impaired the critical conditioning of monocyte-derived macrophages and resulted in spontaneous development of severe colitis.
Recent findings review how IL10 (show IL10 Antibodies)- and IL10R-dependent signaling modulates innate and adaptive immune responses in the murine intestine.
Treatment of mice with rIFN-gamma was sufficient to drive expression of IL-10R1 in the colonic epithelium. Intestinal epithelial-specific IL-10R1-null mice were more susceptible to DSS (show PMP22 Antibodies) colitis associated with increased intestinal permeability.
Inhibition of IL-10R signaling during bacillus Calmette-Guerin (BCG (show SLC11A1 Antibodies)) vaccination increases and balances IFN-gamma (show IFNG Antibodies) and IL-17A (show IL17A Antibodies) responses in favor of the host.
IL-10R subunit-alpha signaling plays a key role in the development as well as B-cell help function of T (follicular helper) cells in vitro and in vivo.
showed here that IL-17A (show IL17A Antibodies)-producing CD4 (show CD4 Antibodies)+ T cells expressed interleukin-10 receptor alpha (IL-10Ralpha) in vivo
Data show that, in an IL-10 (show IL10 Antibodies)-dependent LPS (show TLR4 Antibodies) model of endotoxemia, dampening of the immune response requires expression of IL-10R1 in monocytes/macrophages and/or neutrophils but not in T cells nor B cells.
reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor (show IL10RB Antibodies) antibody
Immunocytochemistry data shows that the region of the adrenal gland responsible for the vast majority of corticosterone synthesis, the zona fasciculata, predominantly expresses the IL-10 (show IL10 Antibodies) receptor 1.
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
interleukin 10 receptor 1
, interleukin-10 receptor subunit alpha
, interleukin 10 receptor, alpha
, interleukin-10 receptor subunit alpha-like
, IL-10 receptor subunit alpha
, IL-10R subunit 1
, IL-10R subunit alpha
, interleukin-10 receptor alpha chain
, interleukin-10 receptor subunit 1