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IL28A encodes a cytokine distantly related to type I interferons and the IL-10 family. Additionally we are shipping Interleukin 28A (Interferon, lambda 2) Kits (23) and Interleukin 28A (Interferon, lambda 2) Proteins (23) and many more products for this protein.
Showing 10 out of 34 products:
Human Polyclonal IL28A Primary Antibody for EIA, WB - ABIN357173
Kotenko, Gallagher, Baurin, Lewis-Antes, Shen, Shah, Langer, Sheikh, Dickensheets, Donnelly: IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. in Nature immunology 2002
Show all 2 references for ABIN357173
IL-28A is capable of exacerbating a T-cell-mediated autoimmune disease.
Data indicate that rotavirus infection induces production of interferon (show IFNA Antibodies)-lambda (IFN-lambda) and interleukin 22 (IL-22 (show IL22 Antibodies)) by intestinal epithelial cells.
IL-28A exerts its antiinflammatory effect by restricting recruitment of IL-1b (show IL1B Antibodies)-expressing neutrophils
The level of IFN-lambda2 was significantly increased in the infected cells treated with with shRNAs against influenza a virus M1.
IFN-lambda2 limits VSV replication in the mouse lung.
Data indicate that IPS-1 (show ISYNA1 Antibodies)-dependent pathway plays a crucial role in type III IFN production by CD8 (show CD8A Antibodies)(+) dendritic cells (DCs) and hepatocytes in response to hepatitis C virus (HCV), leading to cytoplasmic antiviral protein expressions.
NS of severe fever with thrombocytopenia syndrome virus inhibited the activity of IFN-alpha1 (show IFNA1 Antibodies), IFN-beta (show IFNB1 Antibodies), IFN-lambda1 and IFN-lambda2 through inhibition of STAT1 (show STAT1 Antibodies) phosphorylation.
Studies indicate that the type III interferons (IFNs) or IFN-lambdas consists of four members: IFN-lambda1 (IL-29 (show IL29 Antibodies)), IFN-lambda2 (IL28A), IFN-lambda3 (IL-28B (show IL28B Antibodies)) and IFN-lambda4.
Results showed no association between genotypes and alleles of IL28A, IL28B (show IL28B Antibodies) or IL29 (show IL29 Antibodies) polymorphisms and Hepatitis C virus infection.
this study provides evidence for potential IL-28A participation in Behcet's diseaseand its value as a therapeutic agent.
Interferon (show IFNA Antibodies) regulatory factor (IRF)-3 (show IRF3 Antibodies) and -7 are the key transcriptional factors for the induction of IL-28A and IL-28B (show IL28B Antibodies) genes, whereas NF-kappaB (show NFKB1 Antibodies) is an additional requirement for the induction of the IL-29 (show IL29 Antibodies) gene.
The results show that IL-28A/IL-28AR1 dyad-induced wound healing migration requires NF-kappaB (show NFKB1 Antibodies)-mediated MMP-9 (show MMP9 Antibodies) expression by MAPK (show MAPK1 Antibodies) activation.
IL-28 genotype was not associated with response to interferon (show IFNA Antibodies) treatment (OR for GT/GG vs. TT, 0.881 (95%CI 0.388 - 2.002); P = 0.762; OR for CT/CC vs. TT, 0.902 (95%CI 0.458 - 1.778); P = 0.766).
p38 MAPK (show MAPK14 Antibodies) pathway mediates IL-28A-induced cell migration through MMP-9 (show MMP9 Antibodies) expression by activating NF-kappaB (show NFKB1 Antibodies) and AP-1 (show FOSB Antibodies) binding motifs.
Elevated expression of inflammatory cytokines (IL-5 (show IL5 Antibodies), IL-20 (show IL20 Antibodies), and IL-28A) is associated with bladder cancer development.
Plasmacytoid dendritic cells are major producers of IFN-lambda2 (a type III interferon (show IFNA Antibodies)) in response to viral stimulation.
Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.
, interferon lambda-2
, interleukin 28A
, cytokine Zcyto20
, interferon lambda 2
, interferon-lambda 2
, interleukin 28A (interferon, lambda 2)