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IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. Additionally we are shipping Interleukin 31 Kits (52) and Interleukin 31 Proteins (41) and many more products for this protein.
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Human Polyclonal IL31 Primary Antibody for ELISA, WB - ABIN2475000
Castellani, Salini, Frydas, Donelan, Madhappan, Petrarca, Vecchiet, Falasca, Neri, Tete: Interleukin-31: a new cytokine involved in inflammation of the skin. in International journal of immunopathology and pharmacology 2006
The first demonstration of the involvement of the IL-31/IL-31R axis in cancer came from studies in patients with mycosis fungoides/Sezary syndrome, the most frequent, cutaneous T cell lymphoma. Tumor cells were shown to produce IL-31, whose serum levels correlated with pruritus intensity.
IL31 and its receptor, IL31RA (show IL31RA Antibodies), are highly expressed in various human and mouse cancer cell lines, as well as in tumor specimens from cancer patients. MC38 murine colon carcinoma cells depleted of IL31 exhibit an increase in invasive and migratory properties in vitro.
this study shows that IL-31 may be involved in the pathogenesis of asthma and rhinitis; dust mite and mugwort allergy could increase it significantly
While serum TSLP (show TSLP Antibodies) levels were unaffected by concomitant allergies and atopic comorbidities, serum levels of IL-31, IL-33 (show IL33 Antibodies) and sST2 (show SSTR2 Antibodies) were affected to a small extent. We found a positive correlation between TSLP (show TSLP Antibodies), IL-31 and IL-33 (show IL33 Antibodies), and an inverse relationship between IL-33 (show IL33 Antibodies) and sST2 (show SSTR2 Antibodies)
Suggest that IL-31 gene may play a role in the development of systemic lupus erythematosus.
High IL31 expression is associated with Endometrial Cancer.
In a CML (show BCR Antibodies) patient with pruritus receiving imatinib mesylate, IL-31 and IL-33 (show IL33 Antibodies) serum levels were significantly higher than controls. Imatinib could cause keratinocyte injury, the release of IL-33 (show IL33 Antibodies), and the consequent interaction with its receptor on mast cells, inducing IL-31 secretion. The IL-31/IL-33 (show IL33 Antibodies) axis may be involved in the pathogenesis of skin side effects related to imatinib mesylate treatment.
Distinct polymorphic variants of the IL-31 gene may be involved in the patho-genesis of mastocytosis, and IL-31 may be involved in the induction of pruritus in patients with mastocytosis.
Serum/pleural fluid IL-31 levels are elevated in tuberculous pleural effusion.
both SCF (show KITLG Antibodies) and IL-31 play an important role in mediating inflammation and enhancing severity of atopic asthma.
Oncostatin M (show OSM Antibodies) and interleukin-31: Cytokines, receptors, signal transduction and physiology.
IL-31 upregulates IL-31RA (show IL31RA Antibodies) expression in DRG neuron cell bodies, and cutaneous-injected IL-31-induced itching is enhanced by DRG IL-31RA (show IL31RA Antibodies) expression in mice
our results suggest a functional cooperation between NFAT1 (show NFAT1 Antibodies) and JunB (show JUNB Antibodies) in mediating IL-31 gene expression in CD4 (show CD4 Antibodies)(+) T cells
Data not only illustrate various functions that cysteines perform during IL-31 biosynthesis and secretion, but also highlight their potential roles in cytokine effector functions.
IL-31 may be involved in promoting the dermatitis and epithelial responses that characterize allergic and non-allergic diseases
IL-31 interaction with IL-31 receptor (IL-31R) is identified in an acute model of T helper cell type 2 inflammation in the lung.
these data provide the first evidence of a function for IL-31-IL-31R interactions in limiting the magnitude of type 2 inflammatory responses within the intestine.
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004