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IL32 encodes a member of the cytokine family. Additionally we are shipping IL32 Antibodies (153) and IL32 Kits (42) and many more products for this protein.
Showing 9 out of 10 products:
In Kaposi sarcoma (KS) splicing ratio of the IL-32 isoforms showed IL-32gamma as the highest expressed isoform, followed by IL-32beta, in HIV-related KS cases compared with controls. Our data suggest a possible survival mechanism by the splicing of IL-32gamma to IL-32beta and also IL-6 (show IL6 Proteins), IL-8 (show IL8 Proteins), and CXCR1 (show CXCR1 Proteins) signaling pathways to reverse the proapoptotic effect of the IL-32gamma isoform, leading to tumor cell survival and th...
Three single nucleotide polymorphisms (SNPs) (rs28372698, rs12934561, rs4786370) of the IL32 gene have been proposed as modifiers for different diseases. The present study found no significant differences in the genotypic frequencies between the patients and healthy controls and no relation to survival for any of the SNPs.
This study showed that the induction level of IL-32 was increased in chronic rhinosinusitis with nasal polyps compared to normal nasal mucosa and that LPS (show IRF6 Proteins)-induced IL-32 expression in nasal polyp-derived fibroblasts was regulated via the TLR4 (show TLR4 Proteins)/JNK (show MAPK8 Proteins)/AKT (show AKT1 Proteins)/CREB (show CREB1 Proteins) signaling pathway.
findings show that IL-32alpha acts on NK cells to inhibit IL-15 (show IL15 Proteins)-mediated STAT5 (show STAT5A Proteins) phosphorylation and to suppress their IL-15 (show IL15 Proteins)-induced effector molecule expression and cytolytic capacity. IL-32alpha also acted on DCs by downregulating IL-15 (show IL15 Proteins)-induced IL-18 (show IL18 Proteins) production, an important cytokine in NK cell activity.
Thus, endogenous IL-32 is a crucial cytokine involved in the host defense against Leishmania parasites.
Study indicated the overexpression of IL-32 in induced sputum of smokers and chronic obstructive pulmonary disease (COPD (show ARCN1 Proteins)) patients, which was correlated with smoking exposure index and the degree of airway obstruction. It demonstrated that IL-32 might play critical role in smokers with COPD (show ARCN1 Proteins).
this study shows that IL-32 might be involved in the pathogenesis of hepatic fibrosis by inducing TIMP-1 (show TIMP1 Proteins) expression
serum levels of IL-32 and TNF-alpha (show TNF Proteins) may be diagnostic markers, and serum IL-29 (show IL29 Proteins) levels may be associated with good prognosis in patients with gastric cancer
the importance of IL-32 polymorphism and mRNA expression in susceptibility and influence of survival status in lung cancer
These findings suggested that IL-18RAP rs917997, IL-32 rs2015620, IL-22 (show IL22 Proteins) rs1179251, and interactions between these polymorphisms and H. pylori infection were associated with risks of gastric lesions
This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
, interleukin-32 eta
, interleukin-32 small
, interleukin-32 theta
, natural killer cell transcript 4
, natural killer cells protein 4
, tumor necrosis factor alpha-inducing factor