Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial Proteins (IDH2)

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH2 Antibodies (115) and IDH2 Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IDH2 3418 P48735
IDH2 269951 P54071
IDH2 361596 P56574
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top IDH2 Proteins at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Insect cells (Sf9) Human DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$460.85
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
Details
Yeast Arabidopsis thaliana His tag   1 mg Log in to see 60 to 71 Days
$2,927.83
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 60 to 71 Days
$3,147.83
Details
Yeast Wild boar His tag   1 mg Log in to see 60 to 71 Days
$3,147.83
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,147.83
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 15 to 18 Days
$672.00
Details

IDH2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaction Partners

Pig (Porcine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (show IDH3B Proteins)

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (show IDH3B Proteins)

  3. These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (show GRX1 Proteins) activity.

Arabidopsis thaliana Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Leaf IDH activity reduced by 43% in mutant

Human Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Mutations in the IDH1 (show IDH1 Proteins) and IDH2 genes perturb the epigenome through cytosine methylation, histone post-translational modifications and transcription factors. [review]

  2. IDH2 mutation is associated with high-grade gliomas.

  3. these results suggest a potential relationship between SIRT3 (show SIRT3 Proteins) enzymatic activity, IDH2-K413 acetylation-determined dimerization, and a cancer-permissive phenotype

  4. Identification of IDH1 (show IDH1 Proteins) or IDH2 mutations supports the diagnosis of dedifferentiated chondrosarcoma rather than undifferentiated pleomorphic sarcoma of bone.

  5. There are frequent IDH2 R172 mutations in undifferentiated and poorly-differentiated sinonasal carcinomas.

  6. Results showed that TERT promoter mutational status combined with IDH-mutation allowed simple classification of grade II/III gliomas for stratifying patients and clarifying diagnostic accuracy by supplementing standard histopathological criteria.

  7. Results identified IDH2 rs11540478 as a new susceptibility locus for lung cancer.

  8. Functional studies demonstrated that IDH2 and PIK3CA (show PIK3CA Proteins) hotspot mutations are likely drivers of solid papillary carcinoma with reverse polarity

  9. IDH1 (show IDH1 Proteins) and IDH2 mutants inhibit TET-promoted oxidation of RNA 5-methylcytosine to 5hydroxymethylcytosine.

  10. IDH2 mutation is associated with polycythemia vera (show IGF2BP3 Proteins) and essential thrombocythemia.

Cow (Bovine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. The enzyme is highly sensitive to Mg(2 (show MCOLN1 Proteins)+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2 (show MCOLN1 Proteins)+)] in mitochondrial energy metabolism.

Mouse (Murine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Findings demonstrate that IDH2 contributes to degeneration of the DA neuron in the neurotoxin model of Parkinson's Disease.

  2. IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice.

  3. IDH2 and NPM1 (show GJA1 Proteins) mutations synergize in the development and maintenance of acute myeloid leukemia (show BCL11A Proteins) stem-like cells.

  4. 7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144 leading to atherosclerosis.

  5. These data demonstrate the proto-oncogenic role of mutant IDH2.

  6. The tumor tissue of B16F10 cells transfected with IDH2 antisense cDNA exhibited induction of apoptosis and downregulation of angiogenesis markers.

  7. Data indicate that tumor tissues from idh2-/- ((knock-out) mice had significantly decreased HIF-1alpha (show HIF1A Proteins) expression, blunted mRNA expression of HIF-1alpha (show HIF1A Proteins), VEGF (show VEGFA Proteins), and the glucose transport protein Glut-1 (show SLC1A3 Proteins) was also observed.

  8. IDH2 mutants can cooperate with oncogenic Flt3 (show FLT3 Proteins) or Nras (show NRAS Proteins) alleles to drive leukemia in mice by impairing the differentiation of cells of the myeloid lineage

  9. SIRT3 (show SIRT3 Proteins) protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status

  10. Results suggest that mitochondrial NADP(+)-dependent isocitrate dehydrogenase (show IDH1 Proteins) plays a role in apoptosis induced by high glucose and may contribute to various pathologies associated with the long-term complications of diabetes.

IDH2 Protein Profile

Protein Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.

Gene names and symbols associated with IDH2

  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (idh2)
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (IDH2)
  • Isocitrate dehydrogenase [NAD] regulatory subunit 2 (IDH2)
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2)
  • D2HGA2 protein
  • E430004F23 protein
  • F6P23.14 protein
  • F6P23_14 protein
  • ICD-M protein
  • IDH protein
  • Idh-2 protein
  • IDH-II protein
  • IDH2 protein
  • IDHM protein
  • IDP protein
  • IDPm protein
  • isocitrate dehydrogenase II protein
  • isocitrate dehydrogenase subunit 2 protein
  • mNADP-IDH protein
  • NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 2 protein
  • wu:fb33c06 protein
  • wu:fk31e05 protein
  • wu:fq43b01 protein
  • zgc:55485 protein

Protein level used designations for IDH2

isocitrate dehydrogenase 2 (NADP+), mitochondrial , isocitrate dehydrogenase [NADP], mitochondrial , isocitrate dehydrogenase [NADP], mitochondrial-like , NADP(+)-specific ICDH , oxalosuccinate decarboxylase , ICD-M , IDH , IDP , NADP+-specific isocitrate dehydrogenase , NADPH-specific isocitrate dehydrogenase

GENE ID SPECIES
448026 Xenopus (Silurana) tropicalis
453645 Pan troglodytes
701480 Macaca mulatta
100155880 Sus scrofa
100441867 Pongo abelii
816218 Arabidopsis thaliana
3418 Homo sapiens
386951 Danio rerio
380013 Xenopus laevis
431056 Gallus gallus
327669 Bos taurus
269951 Mus musculus
361596 Rattus norvegicus
479043 Canis lupus familiaris
397603 Sus scrofa
Selected quality suppliers for IDH2 Proteins (IDH2)
Did you look for something else?