Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial Proteins (IDH2)

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH2 Antibodies (115) and IDH2 Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IDH2 3418 P48735
IDH2 269951 P54071
IDH2 361596 P56574
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Top IDH2 Proteins at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Insect cells (Sf9) Human DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$504.74
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$860.20
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Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
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Yeast Arabidopsis thaliana His tag   1 mg Log in to see 60 to 71 Days
$2,927.83
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Yeast Macaca fascicularis His tag   1 mg Log in to see 60 to 71 Days
$3,147.83
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Yeast Wild boar His tag   1 mg Log in to see 60 to 71 Days
$3,147.83
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,147.83
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Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$672.00
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IDH2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaction Partners

Arabidopsis thaliana Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Leaf IDH activity reduced by 43% in mutant

Human Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. 6 cases of diffuse glioma that presented a diagnostic challenge due to conflicting IDH1 (show IDH1 Proteins)/IDH2, ATRX (show ATRX Proteins), and 1p/19q results.

  2. In this review, we focus on three key areas in acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)) developmental therapeutics: FLT3 (show FLT3 Proteins) inhibitors, IDH(IDH1 (show IDH1 Proteins) and IDH2 ) inhibitors, and drugs that may be particularly beneficial in secondary AML (show RUNX1 Proteins)

  3. The role of mutant IDH1 (show IDH1 Proteins) and IDH2 inhibitors in the treatment of acute myeloid leukemia (show BCL11A Proteins).

  4. olaparib and other PARP inhibitors killed cells in multiple cancer cell lines that harbor IDH1 (show IDH1 Proteins) and IDH2 mutations. In addition, glioma cell lines generated from patient tumors with IDH1 (show IDH1 Proteins) mutations were vulnerable to the investigational PARP inhibitor talazoparib . In mice, olaparib slowed the growth of implanted IDH1 (show IDH1 Proteins)-mutant tumors.

  5. demonstrate the presence of the IDH2 p.R172K/S mutation in patients with cutaneous localizations of angioimmunoblastic T-cell lymphomas.

  6. an IDH mutant-enriched subtype of cholangiocarcinoma with distinct molecular features including low expression of chromatin modifiers, elevated expression of mitochondrial genes, and increased mitochondrial DNA copy number, is reported.

  7. IDH (show IDH1 Proteins) mutations define a distinct subtype of ICC, a malignancy that is largely refractory to current therapies. Our work demonstrates that IDHm ICC cells are hypersensitive to dasatinib and critically dependent on SRC (show SRC Proteins) activity for survival and proliferation, pointing to new therapeutic strategies against these cancers.

  8. Mutations in the IDH1 (show IDH1 Proteins) and IDH2 genes perturb the epigenome through cytosine methylation, histone post-translational modifications and transcription factors. [review]

  9. IDH2 mutation is associated with high-grade gliomas.

  10. these results suggest a potential relationship between SIRT3 (show SIRT3 Proteins) enzymatic activity, IDH2-K413 acetylation-determined dimerization, and a cancer-permissive phenotype

Mouse (Murine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Increased obesity resistance and insulin (show INS Proteins) sensitivity in mice lacking the IDH2 gene has been documented.

  2. treatment with Mito-TEMPO, a mitochondrial-specific superoxide scavenger, recovered mitochondrial fission-fusion imbalance and blunted mitochondrial superoxide production, and reduced the IDH2 knockdown-induced decrease in MnSOD (show SOD2 Proteins) expression, eNOS (show NOS3 Proteins) phosphorylation and NO production in endothelial cells

  3. Findings demonstrate that IDH2 contributes to degeneration of the DA neuron in the neurotoxin model of Parkinson's Disease.

  4. IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice.

  5. IDH2 and NPM1 (show GJA1 Proteins) mutations synergize in the development and maintenance of acute myeloid leukemia (show BCL11A Proteins) stem-like cells.

  6. 7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144 leading to atherosclerosis.

  7. These data demonstrate the proto-oncogenic role of mutant IDH2.

  8. The tumor tissue of B16F10 cells transfected with IDH2 antisense cDNA exhibited induction of apoptosis and downregulation of angiogenesis markers.

  9. Data indicate that tumor tissues from idh2-/- ((knock-out) mice had significantly decreased HIF-1alpha (show HIF1A Proteins) expression, blunted mRNA expression of HIF-1alpha (show HIF1A Proteins), VEGF (show VEGFA Proteins), and the glucose transport protein Glut-1 (show SLC1A3 Proteins) was also observed.

  10. IDH2 mutants can cooperate with oncogenic Flt3 (show FLT3 Proteins) or Nras (show NRAS Proteins) alleles to drive leukemia in mice by impairing the differentiation of cells of the myeloid lineage

Cow (Bovine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. The enzyme is highly sensitive to Mg(2 (show MCOLN1 Proteins)+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2 (show MCOLN1 Proteins)+)] in mitochondrial energy metabolism.

Pig (Porcine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (show IDH3B Proteins)

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (show IDH3B Proteins)

  3. These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (show GRX1 Proteins) activity.

IDH2 Protein Profile

Protein Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.

Gene names and symbols associated with IDH2

  • isocitrate dehydrogenase subunit 2 (IDH2)
  • isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (IDH2)
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2)
  • isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (Idh2)
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial S homeolog (idh2.S)
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (idh2)
  • isocitrate dehydrogenase [NADP], mitochondrial (LOC100441867)
  • D2HGA2 protein
  • E430004F23 protein
  • F6P23.14 protein
  • F6P23_14 protein
  • ICD-M protein
  • IDH protein
  • Idh-2 protein
  • IDH-II protein
  • IDH2 protein
  • IDHM protein
  • IDP protein
  • IDPm protein
  • isocitrate dehydrogenase II protein
  • isocitrate dehydrogenase subunit 2 protein
  • mNADP-IDH protein
  • NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 2 protein
  • wu:fb33c06 protein
  • wu:fk31e05 protein
  • wu:fq43b01 protein
  • zgc:55485 protein

Protein level used designations for IDH2

NADP(+)-specific ICDH , isocitrate dehydrogenase [NADP], mitochondrial , oxalosuccinate decarboxylase , ICD-M , IDH , IDP , NADP+-specific isocitrate dehydrogenase , NADPH-specific isocitrate dehydrogenase , isocitrate dehydrogenase 2 (NADP+), mitochondrial , isocitrate dehydrogenase [NADP], mitochondrial-like

GENE ID SPECIES
816218 Arabidopsis thaliana
3418 Homo sapiens
269951 Mus musculus
327669 Bos taurus
361596 Rattus norvegicus
380013 Xenopus laevis
386951 Danio rerio
397603 Sus scrofa
448026 Xenopus (Silurana) tropicalis
453645 Pan troglodytes
479043 Canis lupus familiaris
701480 Macaca mulatta
100441867 Pongo abelii
431056 Gallus gallus
100726681 Cavia porcellus
100340796 Oryctolagus cuniculus
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