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Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH2 Antibodies (115) and IDH2 Kits (14) and many more products for this protein.
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Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (show IDH3B Proteins)
analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (show IDH3B Proteins)
These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (show GRX1 Proteins) activity.
Leaf IDH activity reduced by 43% in mutant
Mutations in the IDH1 (show IDH1 Proteins) and IDH2 genes perturb the epigenome through cytosine methylation, histone post-translational modifications and transcription factors. [review]
IDH2 mutation is associated with high-grade gliomas.
these results suggest a potential relationship between SIRT3 (show SIRT3 Proteins) enzymatic activity, IDH2-K413 acetylation-determined dimerization, and a cancer-permissive phenotype
Identification of IDH1 (show IDH1 Proteins) or IDH2 mutations supports the diagnosis of dedifferentiated chondrosarcoma rather than undifferentiated pleomorphic sarcoma of bone.
There are frequent IDH2 R172 mutations in undifferentiated and poorly-differentiated sinonasal carcinomas.
Results showed that TERT promoter mutational status combined with IDH-mutation allowed simple classification of grade II/III gliomas for stratifying patients and clarifying diagnostic accuracy by supplementing standard histopathological criteria.
Results identified IDH2 rs11540478 as a new susceptibility locus for lung cancer.
Functional studies demonstrated that IDH2 and PIK3CA (show PIK3CA Proteins) hotspot mutations are likely drivers of solid papillary carcinoma with reverse polarity
IDH1 (show IDH1 Proteins) and IDH2 mutants inhibit TET-promoted oxidation of RNA 5-methylcytosine to 5hydroxymethylcytosine.
IDH2 mutation is associated with polycythemia vera (show IGF2BP3 Proteins) and essential thrombocythemia.
The enzyme is highly sensitive to Mg(2 (show MCOLN1 Proteins)+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2 (show MCOLN1 Proteins)+)] in mitochondrial energy metabolism.
Findings demonstrate that IDH2 contributes to degeneration of the DA neuron in the neurotoxin model of Parkinson's Disease.
IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice.
IDH2 and NPM1 (show GJA1 Proteins) mutations synergize in the development and maintenance of acute myeloid leukemia (show BCL11A Proteins) stem-like cells.
7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144 leading to atherosclerosis.
These data demonstrate the proto-oncogenic role of mutant IDH2.
The tumor tissue of B16F10 cells transfected with IDH2 antisense cDNA exhibited induction of apoptosis and downregulation of angiogenesis markers.
Data indicate that tumor tissues from idh2-/- ((knock-out) mice had significantly decreased HIF-1alpha (show HIF1A Proteins) expression, blunted mRNA expression of HIF-1alpha (show HIF1A Proteins), VEGF (show VEGFA Proteins), and the glucose transport protein Glut-1 (show SLC1A3 Proteins) was also observed.
IDH2 mutants can cooperate with oncogenic Flt3 (show FLT3 Proteins) or Nras (show NRAS Proteins) alleles to drive leukemia in mice by impairing the differentiation of cells of the myeloid lineage
SIRT3 (show SIRT3 Proteins) protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status
Results suggest that mitochondrial NADP(+)-dependent isocitrate dehydrogenase (show IDH1 Proteins) plays a role in apoptosis induced by high glucose and may contribute to various pathologies associated with the long-term complications of diabetes.
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.
isocitrate dehydrogenase 2 (NADP+), mitochondrial
, isocitrate dehydrogenase [NADP], mitochondrial
, isocitrate dehydrogenase [NADP], mitochondrial-like
, NADP(+)-specific ICDH
, oxalosuccinate decarboxylase
, NADP+-specific isocitrate dehydrogenase
, NADPH-specific isocitrate dehydrogenase