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anti-Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) (ITCH) Antibodies

ITCH encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. Additionally we are shipping Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Proteins (6) and Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ITCH 83737 Q96J02
ITCH 16396 Q8C863
ITCH    
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Top anti-Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Antibodies at antibodies-online.com

Showing 10 out of 70 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Rabbit Un-conjugated WB ITCH Antibody (Center) (ABIN657549) western blot analysis in mouse bra... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain, using ... 100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from mouse brain cells, using ITCH (... 100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Goat Un-conjugated ELISA, WB ABIN334426 (0.03µg/ml) staining of Human Brain (Frontal Cortex) lysate... 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Mouse Un-conjugated IF, WB Western blot analysis of Itch on rat liver lysate. Lane 1: 1:500, lane... Immunofluorescent staining of HeLa cells with anti-Itch antibody. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-ITCH Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:3... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse FITC FACS Flow cytometric analysis of Human ITCH expression in HeLa cells. The c... 50 Tests Log in to see 16 Days
$198.00
Details
Human Rabbit Un-conjugated WB Anti- ITCH Picoband antibody, Western blotting All lanes: Anti ITCH  a... 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details

ITCH Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
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Mouse (Murine) , , ,
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Rat (Rattus) , ,
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Top referenced anti-Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Antibodies

  1. Human Polyclonal ITCH Primary Antibody for ELISA, WB - ABIN1533142 : Chen, Wen, Fukuda, Gavva, Hsu, Akama, Yang-Feng, Shen: Human ITCH is a coregulator of the hematopoietic transcription factor NF-E2. in Genomics 2001 (PubMed)
    Show all 2 references for ABIN1533142

  2. Human Polyclonal ITCH Primary Antibody for IHC, ELISA - ABIN1532110 : Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: The DNA sequence and comparative analysis of human chromosome 20. ... in Nature 2002 (PubMed)
    Show all 2 references for ABIN1532110

  3. Mouse (Murine) Polyclonal ITCH Primary Antibody for WB - ABIN657549 : Lohr, Molleston, Strauss, Torres-Martinez, Sherman, Squires, Rider, Chikwava, Cummings, Morton, Puffenberger: Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease. in American journal of human genetics 2010 (PubMed)

  4. Human Monoclonal ITCH Primary Antibody for IF, WB - ABIN968414 : Perry, Hustad, Swing, OSullivan, Jenkins, Copeland: The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. in Nature genetics 1998 (PubMed)

  5. Human Polyclonal ITCH Primary Antibody for ELISA, WB - ABIN334426 : Di Marcotullio, Ferretti, Greco, De Smaele, Po, Sico, Alimandi, Giannini, Maroder, Screpanti, Gulino: Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. in Nature cell biology 2006 (PubMed)

More Antibodies against Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Interaction Partners

Human Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) (ITCH) interaction partners

  1. LRAD3 is a component of pathways that function effectively to modulate Itch and Nedd4 auto-ubiquitination and levels.

  2. Cytomegalovirus UL42 induced the ubiquitination and degradation of human Itch in virus-infected fibroblasts, and was partially colocalized with p62 (show GTF2H1 Antibodies), a ubiquitin-binding protein, and CD63 (show CD63 Antibodies), a marker of lysosome and multivesicular bodies.

  3. catalytic activity of Itch toward different SH3 domain (show ITSN1 Antibodies)-containing proteins was similar, except for beta-PIX (show ARHGEF7 Antibodies) that was not readily ubiquitylated even though it could interact with an affinity comparable to those of other substrates tested

  4. Cell proliferation of hepatocellular carcinoma cells mediated by miR (show MLXIP Antibodies)-411, is through suppression of ITCH expression.

  5. In the absence of Ndfip1, the Nedd4 family member Itch can bind an E2 but cannot accept ubiquitin onto its catalytic cysteine.

  6. These observations indicate that ITCH is involved in the cytosolic quality control pathway and may help to explain how abnormal proteins are targeted by QC ubiquitin-protein ligases.

  7. Results suggest that Itch is a positive regulator of the TGF-beta (show TGFB1 Antibodies)-mediated Smad (show SMAD1 Antibodies) signaling pathway via Smad7 (show SMAD7 Antibodies) ubiquitination and protein degradation.

  8. ITCH up-regulation and LATS1 (show LATS1 Antibodies) down-regulation were closely associated with tumorigenesis and progression of SCC (show CYP11A1 Antibodies)

  9. these observations reveal that Itch and Yap1 (show YAP1 Antibodies) have antagonistic roles in the regulation of ASPP2 (show TP53BP2 Antibodies) protein stability through competing post-translational regulatory mechanism of ASPP2 (show TP53BP2 Antibodies).

  10. The C-terminal domain of PTCH1 (show PTCH1 Antibodies) interacts with and is ubiquitylated on K1413 by the E3 ubiquitin-protein ligase Itchy homolog Itch.

Mouse (Murine) Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) (ITCH) interaction partners

  1. CUL4B links two distinct spermatogenetic processes to a single E3 ligase, highlighting the significance of ubiquitin modification during spermatogenesis.

  2. Impaired ITCH results in heightened TNF (show TNF Antibodies) signaling. ITCH-/- mouse's spontaneous lung inflammation and subsequent death can be delayed when TNF (show TNF Antibodies) signaling is genetically deleted.

  3. ITCH modulates SIRT6 (show SIRT6 Antibodies) and SREBP2 (show SREBF2 Antibodies) to influence lipid metabolism and atherosclerosis in ApoE (show APOE Antibodies) null mice

  4. In the absence of Ndfip1, the Nedd4 family member Itch can bind an E2 but cannot accept ubiquitin onto its catalytic cysteine.

  5. The E3 ubiquitin ligase (show MUL1 Antibodies) Itch inhibits p38alpha (show MAPK14 Antibodies) signaling and skin inflammation through the ubiquitylation of Tab1 (show TAB1 Antibodies).

  6. Ndfip1 (show NDFIP1 Antibodies) regulates itch ligase activity and airway inflammation via UbcH7 (show UBE2L3 Antibodies).

  7. The expression of Th2 cytokines by Treg cells was increased in the absence of Itch. Fate mapping revealed that a fraction of Treg cells lost Foxp3 (show FOXP3 Antibodies) expression independently of Itch.

  8. identify Itch as a regulator of Oct4 (show POU5F1 Antibodies) stability and transcriptional activity, establishing a functional link between an E3 ligase and the regulation of pluripotency

  9. Itch interacts with the deubiquitinating enzyme and is required for deubiquitination of TRAF6 (show TRAF6 Antibodies), thus limiting RANKL (show TNFSF11 Antibodies)-induced osteoclast formation

  10. Itch directly associates with and ubiquitinates PI4KIIalpha, and both proteins colocalize on endosomes containing Wnt (show WNT2 Antibodies)-activated frizzled 4 (Fz4 (show FZD4 Antibodies)) receptor

Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) (ITCH) Antigen Profile

Protein Summary

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with ITCH

  • itchy E3 ubiquitin protein ligase (ITCH) antibody
  • itchy, E3 ubiquitin protein ligase (Itch) antibody
  • 6720481N21Rik antibody
  • 8030492O04Rik antibody
  • A130065M08 antibody
  • AIF4 antibody
  • AIP4 antibody
  • C230047C07Rik antibody
  • dJ468O1.1 antibody
  • NAPP1 antibody

Protein level used designations for ITCH

E3 ubiquitin-protein ligase Itchy homolog , NFE2-associated polypeptide 1 , atrophin-1 interacting protein 4 , dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4)) , itchy E3 ubiquitin protein ligase homolog , E3 ubiquitin-protein ligase Itchy

GENE ID SPECIES
83737 Homo sapiens
16396 Mus musculus
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