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Required for normal cytokinesis during mitosis. Additionally we are shipping Jumping Translocation Breakpoint Antibodies (19) and Jumping Translocation Breakpoint Proteins (7) and many more products for this protein.
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Downregulation of the PAR expression increases the Bax (show BAX ELISA Kits)/Bcl-2 (show BCL2 ELISA Kits) ratio and Bax (show BAX ELISA Kits) expression, and thus induces the G2-M phase arrest and apoptosis of PC3 (show PCSK1 ELISA Kits) cells.
Silencing of the JTB resulted in an increase in the phosphorylation of p65 (show GORASP1 ELISA Kits) in HepG2 cells.
The JTB structure has a distant relationship to the midkine (show MDK ELISA Kits)/pleiotrophin (show PTN ELISA Kits) fold, particularly in the conservation of distinctive disulfide bridge patterns.
Due to its involvement in cell cycle and its overexpression in several human cancers PAR could represent an attractive target for therapeutic intervention.
Among ten hepatocellular carcinoma cases with amplicon 1q21-q22, significant gene expression level of JTB, SHC1 (show SHC1 ELISA Kits), CCT3 (show CCT3 ELISA Kits) and COPA (show COPA ELISA Kits) in the tumors than the paired adjacent non-malignant liver tissues.
Overexpression of JTB conferred resistance to apoptosis induced by ultraviolet radiation
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
jumping translocation breakpoint
, protein JTB
, jumping translocation breakpoint protein
, prostate androgen-regulated protein