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Junctophilin 3 Proteins (JPH3)

Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Additionally we are shipping Junctophilin 3 Antibodies (76) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
JPH3 57338 Q8WXH2
JPH3 57340 Q9ET77
Rat JPH3 JPH3 307916  
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Top Junctophilin 3 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details

JPH3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine) ,
,

More Proteins for Junctophilin 3 (JPH3) Interaction Partners

Human Junctophilin 3 (JPH3) interaction partners

  1. The present study aimed to characterize the genetic basis of the Huntington disease (show HTT Proteins) phenotype in South Africans and to investigate the possible origin of the JPH3 mutation.

  2. JPH3 mutations should be considered in the differential diagnosis of early-onset dementia and hypokinetic-rigid syndromes in individuals of African descent.

  3. The pathogenic mechanism of Huntington disease (show HTT Proteins)-like 2 is multifactorial, involving both a toxic gain of function of JPH3 RNA transcripts and a toxic loss of JPH3 expression in an experimental Huntington disease (show HTT Proteins)-like 2 mouse model.

  4. This study reveled the an antisense CAG repeat (show CELF3 Proteins) transcript at JPH3 locus mediates expanded polyglutamine protein toxicity in Huntington's disease-like 2 mice.

  5. CAG/CTG repeat expansions at the Huntington's disease (HD)-like 2 locus have been identified in the gene encoding junctophilin-3 in an HD patient who carried an allele with 50 uninterrupted repeats.

  6. This report on a South African family that presented with progressive dementia and a movement disorder affecting numerous family members. Genotyping of the JPH3 CTG repeat revealed pathogenic expansions in three affected individuals.

  7. 244 Patients with the diagnosis of Huntington's Disease and without mutation of the IT15 (show HTT Proteins) gene revealed one case of SCA17 (show TBP Proteins) but did not disclose the presence of two other diseases with a similar clinical manifestation: DRPLA (show ATN1 Proteins) and HDL2.

  8. HDL2 is caused by a pathological expansion of CAG/CTG triplets in exon 2A of the JPH3 gene.

  9. Data revealed that six polymorphisms of F10, PITRM1, PCSK2, JPH3, MYO7B, and AKAP12 were related (P<0.05) to the prevalence of chronic kidney disease.

Mouse (Murine) Junctophilin 3 (JPH3) interaction partners

  1. Motor discoordination in mutant mice lacking junctophilin type 3

  2. Gene expression was slightly altered in the JP-3 and JP-4 (show JPH4 Proteins) Knockout cerebellum.

Junctophilin 3 (JPH3) Protein Profile

Protein Summary

Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. CAG/CTG repeat expansions at the Huntington's disease (HD)-like 2 locus have been identified in this gene, which is a member of the junctophilin gene family. Alternatively spliced transcript variants have been described for this gene.

Gene names and symbols associated with Junctophilin 3 Proteins (JPH3)

  • junctophilin 3 (JPH3)
  • junctophilin 3 (jph3)
  • junctophilin 3 (Jph3)
  • CAGL237 protein
  • fc26e06 protein
  • HDL2 protein
  • JP-3 protein
  • Jp3 protein
  • si:ch211-255l14.9 protein
  • TNRC22 protein
  • wu:fc26e06 protein

Protein level used designations for Junctophilin 3 Proteins (JPH3)

junctophilin 3 , junctophilin-3-like , junctophilin type 3 , junctophilin-3 , trinucleotide repeat containing 22

GENE ID SPECIES
468063 Pan troglodytes
100018486 Monodelphis domestica
100411387 Callithrix jacchus
100445395 Pongo abelii
324354 Danio rerio
415830 Gallus gallus
57338 Homo sapiens
489669 Canis lupus familiaris
507713 Bos taurus
57340 Mus musculus
307916 Rattus norvegicus
100512414 Sus scrofa
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