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KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. Additionally we are shipping K(lysine) Acetyltransferase 2A Proteins (12) and many more products for this protein.
Showing 10 out of 110 products:
Human Polyclonal KAT2A Primary Antibody for EIA, WB - ABIN356619
Kikuchi, Takami, Nakayama: GCN5: a supervisor in all-inclusive control of vertebrate cell cycle progression through transcription regulation of various cell cycle-related genes. in Gene 2005
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Human Monoclonal KAT2A Primary Antibody for EIA, IF - ABIN487348
Wiper-Bergeron, Salem, Tomlinson, Wu, Haché: Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5. in Proceedings of the National Academy of Sciences of the United States of America 2007
Show all 3 references for ABIN487348
Human Polyclonal KAT2A Primary Antibody for EIA, WB - ABIN952986
Kelly, Lerin, Haas, Gygi, Puigserver: GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation. in The Journal of biological chemistry 2009
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Human Polyclonal KAT2A Primary Antibody for EIA, FACS - ABIN952987
Mao, Gluck, Li, Maine, Li, Zaidi, Repaka, Mayo, Burstein: GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA. in Genes & development 2009
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Human Polyclonal KAT2A Primary Antibody for WB - ABIN387930
Oishi, Kitagawa, Wada, Takezawa, Tora, Kouzu-Fujita, Takada, Yano, Yanagisawa, Kato: An hGCN5/TRRAP histone acetyltransferase complex co-activates BRCA1 transactivation function through histone modification. in The Journal of biological chemistry 2006
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Human Polyclonal KAT2A Primary Antibody for ELISA, WB - ABIN1534045
Yang, Ogryzko, Nishikawa, Howard, Nakatani: A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. in Nature 1996
Data suggest that expression of GCN5 (histone acetyltransferase GCN5) is induced in skeletal muscle during a 48-hour fast; in contrast, expression of SIRT1 (sirtuin 1 (show SIRT1 Antibodies)) remains unchanged.
Orc5 (show ORC5 Antibodies) associates with the H3 histone (show HIST1H3B Antibodies) acetyl transferase (show HAT1 Antibodies) GCN5 (also known as KAT2A), and this association enhances the chromatin-opening function of Orc5 (show ORC5 Antibodies).
Methionine was the only essential amino acid that rapidly induced PGC-1alpha acetylation through activating the GCN5 acetyltransferase.
these results may point to the GCN5-NF-kappaB (show NFKB1 Antibodies) pathway as a novel potential molecular target for stem cell mediated regenerative medicine and the treatment of metabolic bone diseases such as osteoporosis.
Acetyltransferase p300 (show EP300 Antibodies) collaborates with chromodomain helicase DNA-binding protein 4 (CHD4 (show CHD4 Antibodies)) to facilitate DNA double-strand break repair
Suggest lysine acetyltransfer as a potential regulator of platelet actin dynamics, and potential roles for lysine acetylation in the molecular coordination of platelet activation and function.
Data uncover GCN5 as a negative regulator of C/EBPalpha (show CEBPA Antibodies) and demonstrate the importance of C/EBPalpha (show CEBPA Antibodies) acetylation in myeloid differentiation.
GCN5 Potentiates Glioma Proliferation and Invasion via STAT3 (show STAT3 Antibodies) and AKT (show AKT1 Antibodies) Signaling Pathways
results thus demonstrate that the catalytic activity of GCN5 is stimulated by subunits of the ADA2a (show TADA2A Antibodies)- or ADA2b (show TADA2B Antibodies)-containing HAT (show MGEA5 Antibodies) modules and is further increased by incorporation of the distinct HAT (show MGEA5 Antibodies) modules in the ATAC (show XCL1 Antibodies) or SAGA holo-complexes
GCN5 plays a positive role in human colon cancer development, and its suppression holds a great therapeutic potential in antitumor therapy
In addition to reducing atrogene expression, surprisingly inhibiting NF-kappaB (show NFKB1 Antibodies) with IkappaBalpha (show NFKBIA Antibodies)-SR or by GCN5 knockdown in these muscles also enhanced AKT (show AKT1 Antibodies) and mechanistic target of rapamycin (mTOR (show FRAP1 Antibodies)) activities, which also contributed to the reduction in atrophy.
Gcn5 and PCAF (show KAT2B Antibodies) repress IFN-beta (show IFNB1 Antibodies) production in an enzymatic activity-independent and non-transcriptional manner: by inhibiting the innate immune signaling kinase TBK1 (show TBK1 Antibodies) in the cytoplasm.
GCN5 and HDAC1 (show HDAC1 Antibodies) are the crucial enzymes that regulating epigenetic reprogramming; we observed dynamic changes in the expression levels of GCN5 and HDAC1 (show HDAC1 Antibodies) during embryo development
In conclusion, these data establish Kat2a as a novel and essential regulator of hippocampal memory consolidation.
Study reveals that Gcn5/PCAF (show KAT2B Antibodies) facilitate adipogenesis through regulation of PPARgamma (show PPARG Antibodies) expression and regulate brown adipogenesis by influencing Prdm16 (show PRDM16 Antibodies) expression.
Sirt6 interacts with and modifies GCN5, enhancing GCN5's activity.
Data support a model in which p23 and GCN5 regulate diverse multistep pathways by controlling the longevity of protein-DNA complexes.
Data have defined an important role for GCN5 in NSC and provided evidence that GCN5 is an important Myc (show MYC Antibodies) transcriptional cofactor in vivo.
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009
histone acetyltransferase KAT2A
, general control of amino acid synthesis 5-like 2
, GCN5 general control of amino-acid synthesis 5-like 2
, general control of amino acid synthesis protein 5-like 2
, K(lysine) acetyltransferase 2A
, GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2
, General control of amino acid synthesis, yeast, homolog-like 2
, histone acetyltransferase GCN5
, lysine acetyltransferase 2A
, GCN5 general control of amino acid synthesis-like 2
, general control of amino acid synthesis, yeast homolog-like 2
, general control of amino acid synthesis-like 2