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The protein encoded by KIN is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Additionally we are shipping KIN Antibodies (28) and many more products for this protein.
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Human KIN Protein expressed in Escherichia coli (E. coli) - ABIN1098450
Mazin, Timchenko, Ménissier-de Murcia, Schreiber, Angulo, de Murcia, Devoret: Kin17, a mouse nuclear zinc finger protein that binds preferentially to curved DNA. in Nucleic acids research 1994
identification of KIN17 as a component of the human spliceosome indicate that this protein may participate in RNA processing
overexpression of KIN rendered colorectal cancer cells enriching cancer stem cell (CSC) markers and CSC phenotype, and silencing KIN reduced CSC markers and CSC phenotype.
Trimethylated at Lys (show LYZ Proteins)-135 by METTL22 (show METTL22 Proteins)
up-regulation of kin17 is strongly associated with cellular proliferation, DNA replication, DNA damage response and breast cancer development
The overexpression of human kin17 protein in vivo and the introduction of increased amounts of human kin17 protein in an in vitro assay reduced T-antigen-dependent DNA replication.
results indicate the presence of functional XPA (show XPA Proteins) and XPC (show XPC Proteins) proteins is essential for the up-regulation of the KIN17 gene after UVC irradiation; also show that the integrity of global genome repair is required to trigger KIN17 gene expression
KIN17 protein may be a component of the DNA replication machinery that participates in the cellular response to unrepaired DSBs, and an impaired KIN17 pathway leads to an increased sensitivity to ionizing radiation.
Kin17 protein strongly associates in vivo with DNA fragments containing replication origins in both human HeLa and monkey CV-1 cells.
C-terminal domain of human KIN17 has a basic pI, heavy-atom derivatives were obtained by soaking crystals with negatively charged ions such as tungstate & iodine. Replacement of LiCl by KI in cryosolution allowed determination of phases from iodide ions.
Analysis of KIN17 structure complexed with tungstate shows structural variability within the domain
Thus, human KIN17 region 51-160 might rather be involved in protein-protein interaction through its conserved surface centered on the 3(10)-helix.
The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants.
DNA/RNA-binding protein KIN17
, KIN, antigenic determinant of recA protein homolog
, binding to curved DNA
, HsKin17 protein