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Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Additionally we are shipping KATNAL1 Antibodies (30) and KATNAL1 Kits (3) and many more products for this protein.
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microdeletion 13q12.3 represents a novel clinically recognizable condition and that the microtubule severing gene KATNAL1 and the chromatin-associated gene HMGB1 (show HMGB1 Proteins) are candidate genes for intellectual disability inherited in an autosomal dominant pattern.
KATNAL1 gene sequence variants are not associated with azoospermia.
KL1 (show KITLG Proteins)-mediated microtubule severing is utilized to generate microtubule seeds within the poles and loss of this activity alters the normal balance of motor-generated forces that determine spindle length.
The identification of KATNAL1 as an essential regulator of male fertility provides a significant novel entry point into advancing our understanding of how SC microtubule dynamics promotes male fertility
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth (By similarity).
katanin p60 ATPase-containing subunit A-like 1
, p60 katanin-like 1