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Kelch-Like 12 (Drosophila) Proteins (KLHL12)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. Additionally we are shipping KLHL12 Antibodies (54) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KLHL12 240756 Q8BZM0
KLHL12 59349 Q53G59
KLHL12 266772 Q8R2H4
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Top KLHL12 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$246.96
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,630.00
Details

KLHL12 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,
Rat (Rattus)

More Proteins for Kelch-Like 12 (Drosophila) (KLHL12) Interaction Partners

Mouse (Murine) Kelch-Like 12 (Drosophila) (KLHL12) interaction partners

  1. KLHL12 specifically interacts with the D4 polymorphism, thereby building up a Cul3 (show CUL3 Proteins)-E3 ligase complex with substrate specificity toward the D4 receptor

Human Kelch-Like 12 (Drosophila) (KLHL12) interaction partners

  1. KLHL12 promotes ubiquitination of the dopamine D4 receptor (show DRD4 Proteins) on non-lysine residues.

  2. molecular cloning and characterization of a novel gene, encoded a human kelch protein containing 568 amino acid residues, termed hDKIR.

  3. KLHL12 specifically interacts with the D4 polymorphism, thereby building up a Cul3 (show CUL3 Proteins)-E3 ligase complex with substrate specificity toward the D4 receptor

KLHL12 Protein Profile

Protein Summary

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3 (By similarity).

Gene names and symbols associated with KLHL12

  • kelch-like 12 (Drosophila) (KLHL12)
  • kelch-like family member 12 (klhl12)
  • kelch-like 12 (Drosophila) (klhl12)
  • kelch-like 12 (Klhl12)
  • kelch-like family member 12 (KLHL12)
  • kelch-like family member 12 (Klhl12)
  • C3IP1 protein
  • DKIR protein
  • hDKIR protein
  • wu:fi60g03 protein
  • zgc:92570 protein

Protein level used designations for KLHL12

kelch-like 12 (Drosophila) , kelch-like 12 , kelch-like protein 12 , fi60g03 , CUL3-interacting protein 1 , kelch-like protein C3IP1 , DKIR homolog

GENE ID SPECIES
421171 Gallus gallus
431860 Xenopus laevis
457634 Pan troglodytes
479996 Canis lupus familiaris
492362 Danio rerio
240756 Mus musculus
768068 Bos taurus
59349 Homo sapiens
266772 Rattus norvegicus
Selected quality suppliers for KLHL12 Proteins (KLHL12)
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