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Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. Additionally we are shipping KLHL12 Antibodies (56) and many more products for this protein.
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KLHL12 specifically interacts with the D4 polymorphism, thereby building up a Cul3 (show CUL3 Proteins)-E3 ligase complex with substrate specificity toward the D4 receptor
p44 (show GTF2H2 Proteins)/42 MAPK (show MAPK1 Proteins) phosphorylation, the signaling pathway which is often regulated by beta-arrestins is not influenced by KLHL12, but seems to be exclusively mediated by Galphai protein upon dopamine D4 receptor (show DRD4 Proteins) stimulation.
KLHL12 promotes ubiquitination of the dopamine D4 receptor (show DRD4 Proteins) on non-lysine residues.
molecular cloning and characterization of a novel gene, encoded a human kelch protein containing 568 amino acid residues, termed hDKIR.
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3 (By similarity).
kelch-like 12 (Drosophila)
, kelch-like 12
, kelch-like protein 12
, CUL3-interacting protein 1
, kelch-like protein C3IP1
, DKIR homolog