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KEAP1 encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Additionally we are shipping Kelch-Like ECH-Associated Protein 1 Antibodies (135) and Kelch-Like ECH-Associated Protein 1 Proteins (9) and many more products for this protein.
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Up-regulation of KEAP1 is associated with carcinogenesis and progression of Salivary Adenoid Cystic Carcinoma.
Studies demonstrate that Keap1-Nrf2 (show GABPA ELISA Kits) pathway is important to orchestrate an elaborate genetic program that enhances the intrinsic cytoprotective functions, including drug metabolizing, antioxidant and antiinflammatory networks. [review]
Studies propose that Keap1 activity and Nrf2 (show GABPA ELISA Kits) are regulated by interactions of Trx1 (show MLL ELISA Kits) system enzymes with oxidants. [review]
Accumulating evidence suggests that dysregulation of Keap1-Nrf2 (show GABPA ELISA Kits) pathway resulting in constitutively active Nrf2 (show GABPA ELISA Kits) and increased expression of cytoprotective Nrf2 (show GABPA ELISA Kits) target genes, has a pivotal role in cancer. [review]
expression of Nrf2 (show GABPA ELISA Kits)-Keap1 is abnormal in osteosarcoma tissue and shows significant clinical relevance for determining the prognosis of osteosarcoma
that targeted repression of Keap1 and activation of Nrf2 pathway, in part, underlies the protective effects of miR-7 against 1-methyl-4-phenylpyridinium (MPP+)-induced toxicity in SH-SY5Y
findings reveal that Keap1 regulates cell migration by affecting the subcellular localization and activity of cortactin (show CTTN ELISA Kits) independently of its role in oxidant stress responses.
The Nrf2 (show GABPA ELISA Kits)-Keap1 pathway is the major regulator of cytoprotective responses to oxidative and electrophilic stress. (Review)
Keap1 functions as a suppressor of tumor metastasis by targeting the Nrf2 (show GABPA ELISA Kits)/S100P (show S100P ELISA Kits) pathway in NSCLC cells.
electrophilic moiety in caffeic acid is essential for the oxidation of the Keap1 protein It (show KRT20 ELISA Kits) should be noted that while the nucleophilic moiety (the catechol/quinone moiety) can provide scavenging ability it cannot contribute directly to Nrf2 (show GABPA ELISA Kits) induction
the potency of 15d-PGJ2 as a signalling molecule (show GDF5 ELISA Kits) in endothelial cells is significantly enhanced by the accumulation of the covalent adduct with 15d-PGJ2 and endogenous Keap1 over the time of exposure to the prostaglandin
chronic hyperglycemic conditions, Keap1 inhibition increased Nrf2 (show NFE2L2 ELISA Kits) nuclear translocation, increased antioxidant gene expression, and reduced ROS (show ROS1 ELISA Kits) production to normoglycemic levels.
conclusion, increased Keap1/Nrf2 (show NFE2L2 ELISA Kits) signaling in the liver is accompanied by repressed gluconeogenesis and lipogenesis that can, at least partially, explain the ameliorated diabetic phenotype in the Keap1-hypo mice.
Keap1 utilizes multiple cysteine residues specifically and/or collaboratively as sensors for the detection of a wide range of environmental stresses.
iron deficiency induced the nuclear translocation of Nrf2 (show NFE2L2 ELISA Kits) via Keap1 degradation by autophagy and subsequently upregulated expression of HO-1 (show HMOX1 ELISA Kits).
These results strongly suggest that p62 plays a crucial role in preventing fenofibrate-induced cell death.
Keap1 knockdown caused severe disruption in both the redox cycle and the cell cycle of replicating hepatocytes.
LXR (show NR1H3 ELISA Kits) agonist can enhance the functional survival of transplanted AD-MSCs in infarcted myocardium, at least partially, via modulation of the TLR4 (show TLR4 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits) and Keap-1/Nrf-2 (show NFE2L2 ELISA Kits) signaling pathways.
data confirm a role for GNOM in endoplasmic reticulum (ER)-Golgi trafficking and reveal that a GNL1 (show GNL1 ELISA Kits)/GNOM-mediated early secretory pathway selectively regulates PIN1 (show PIN1 ELISA Kits) basal polarity establishment in a manner essential for normal plant development
Results implicate p62 (show GTF2H1 ELISA Kits)-dependent autophagic degradation of Keap1 by palmitate as a mechanism contributing to hepatocyte lipoapoptosis.
mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2 (show NFE2L2 ELISA Kits), indicating that the presence of either Cys (show DNAJC5 ELISA Kits)-273 or Cys (show DNAJC5 ELISA Kits)-288 is sufficient for fish Keap1 molecules to fully function
study reports that the Keap1-Nrf2 (show NFE2L2 ELISA Kits) system comprises discrete sensor sites, including the Keap1 cysteines Cys (show DNAJC5 ELISA Kits)-151 and Cys (show DNAJC5 ELISA Kits)-273, for a variety of Nrf2 (show NFE2L2 ELISA Kits)-activating compounds
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
kelch-like ECH-associated protein 1
, cytosolic inhibitor of Nrf2
, kelch-like family member 19
, kelch-like protein 19
, NRF2 cytosolic inhibitor
, ring canal protein