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KEAP1 encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Additionally we are shipping Kelch-Like ECH-Associated Protein 1 Antibodies (141) and Kelch-Like ECH-Associated Protein 1 Proteins (11) and many more products for this protein.
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miR (show MLXIP ELISA Kits)-200a was found to interact with the 3'-untranslated region of Keap1, the native regulator of Nrf2 (show GABPA ELISA Kits).
We present the case that chemoprevention through the Keap1/Nrf2 (show GABPA ELISA Kits) system may be context dependent and that the Nrf2 (show GABPA ELISA Kits) "dose-response curve" for electrophilic and redox balance may not be monotonic.
Immunohistochemical assays were used to measure the expression of Keap1 protein in breast cancer tissue and adjacent normal tissue, and its clinical significance was explored. We observed that 24.6% breast cancer tissue samples were positive for Keap1, a significantly lower proportion than that seen with adjacent normal tissue specimens
c-myc (show MYC ELISA Kits) plays a key role in MBD1 (show DPEP1 ELISA Kits) mediated epigenetic silencing of KEAP1.
Results show up-regulation of TrkB (show NTRK2 ELISA Kits) and down-regulation of Runx3 (show RUNX3 ELISA Kits) and Keap1 in breast cancer cells and suggest that TrkB (show NTRK2 ELISA Kits) plays a key role in tumorigenicity and metastasis of breast cancer cells through suppression of Runx3 (show RUNX3 ELISA Kits) or Keap1.
Inhibition of NRF2 (show GABPA ELISA Kits) by KEAP1 overexpression compromises metabolic reprogramming of fibroblasts and results in reduced efficiency of induced pluripotent stem cells colony formation.
Induction of GSH-related genes xCT (show SLC7A11 ELISA Kits) and GCLM (show GCLM ELISA Kits) were oxygen and Bach1 (show BACH1 ELISA Kits)-insensitive during long-term culture under 5% O2, providing the first evidence that genes related to GSH synthesis mediate protection afforded by Nrf2 (show GABPA ELISA Kits)-Keap1 defense pathway
Up-regulation of KEAP1 is associated with carcinogenesis and progression of Salivary Adenoid Cystic Carcinoma.
Studies demonstrate that Keap1-Nrf2 (show GABPA ELISA Kits) pathway is important to orchestrate an elaborate genetic program that enhances the intrinsic cytoprotective functions, including drug metabolizing, antioxidant and antiinflammatory networks. [review]
Studies propose that Keap1 activity and Nrf2 (show GABPA ELISA Kits) are regulated by interactions of Trx1 (show MLL ELISA Kits) system enzymes with oxidants. [review]
the potency of 15d-PGJ2 as a signalling molecule (show GDF5 ELISA Kits) in endothelial cells is significantly enhanced by the accumulation of the covalent adduct with 15d-PGJ2 and endogenous Keap1 over the time of exposure to the prostaglandin
Caffeic acid induces Nrf2 (show NFE2L2 ELISA Kits) activation by decreasing the expression of its inhibitor protein Keap1 and blocking the binding of Nrf2 (show NFE2L2 ELISA Kits) with Keap1.
Hepatocyte-specific deletion of Keap1 triggering constitutive Nrf2 (show NFE2L2 ELISA Kits) activation shifts hepatic metabolism towards increased lipid catabolism, reduced liponeogenesis and activation of the pentose phosphate pathway.
findings reveal that Keap1 regulates cell migration by affecting the subcellular localization and activity of cortactin (show CTTN ELISA Kits) independently of its role in oxidant stress responses.
chronic hyperglycemic conditions, Keap1 inhibition increased Nrf2 (show NFE2L2 ELISA Kits) nuclear translocation, increased antioxidant gene expression, and reduced ROS (show ROS1 ELISA Kits) production to normoglycemic levels.
conclusion, increased Keap1/Nrf2 (show NFE2L2 ELISA Kits) signaling in the liver is accompanied by repressed gluconeogenesis and lipogenesis that can, at least partially, explain the ameliorated diabetic phenotype in the Keap1-hypo mice.
Keap1 utilizes multiple cysteine residues specifically and/or collaboratively as sensors for the detection of a wide range of environmental stresses.
iron deficiency induced the nuclear translocation of Nrf2 (show NFE2L2 ELISA Kits) via Keap1 degradation by autophagy and subsequently upregulated expression of HO-1 (show HMOX1 ELISA Kits).
These results strongly suggest that p62 plays a crucial role in preventing fenofibrate-induced cell death.
Keap1 knockdown caused severe disruption in both the redox cycle and the cell cycle of replicating hepatocytes.
LXR (show NR1H3 ELISA Kits) agonist can enhance the functional survival of transplanted AD-MSCs in infarcted myocardium, at least partially, via modulation of the TLR4 (show TLR4 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits) and Keap-1/Nrf-2 (show NFE2L2 ELISA Kits) signaling pathways.
mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2 (show NFE2L2 ELISA Kits), indicating that the presence of either Cys (show DNAJC5 ELISA Kits)-273 or Cys (show DNAJC5 ELISA Kits)-288 is sufficient for fish Keap1 molecules to fully function
study reports that the Keap1-Nrf2 (show NFE2L2 ELISA Kits) system comprises discrete sensor sites, including the Keap1 cysteines Cys (show DNAJC5 ELISA Kits)-151 and Cys (show DNAJC5 ELISA Kits)-273, for a variety of Nrf2 (show NFE2L2 ELISA Kits)-activating compounds
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
kelch-like ECH-associated protein 1
, cytosolic inhibitor of Nrf2
, kelch-like family member 19
, kelch-like protein 19
, NRF2 cytosolic inhibitor
, ring canal protein