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The KLHL1 protein belongs to a family of actin-organizing proteins related to Drosophila Kelch (Nemes et al., 2000 [PubMed 10888605]).[supplied by OMIM, Feb 2010].. Additionally we are shipping KLHL1 Antibodies (73) and many more products for this protein.
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KLHL1 requires actin-polymerization to increase T-Type Calcium Channel alpha(1H) currents
KLHL1 interacts with Cav3.2 (show CACNA1H Proteins) and modulates T-type calcium currents by increasing current deactivation kinetics and current density and calcium influx.
MRP2/KLHL1 has a role, through its interaction with actin, in the process elongation of oligodendrocytes
KLHL! was widely distributed throughout the mouse brain. In the mouse testis, Sca8 transcript colocalized with Klhl1 mRNA in the spermatogenic cells.
Dlk1 (show DLK1 Proteins) is required to prevent premature expression of Dat (show SLC6A3 Proteins) in meso-diencephalic dopamine neuronal precursors as part of the multifaceted process of neuronal differentiation driven by Nurr1 (show NR4A2 Proteins) and Pitx3 (show PITX3 Proteins).
Renal transplant recipients T carriers of C24T MRP2 (show ABCC2 Proteins) with macrolides treatment were associated with reduced mycophenolic acid area under curve in steady-state conditions
This study provides, for the first time, insights into the involvement of MRP2 in neurite outgrowth, which occurs in a GSK3beta-dependent manner.
modulatory effect of KLHL1 on the P/Q-type calcium channel function, suggesting a possible novel role for KLHL1 in cellular excitability.
KLHL1 was expressed in human brain and kidney, but was also in other tissues, such as prostate gland, small intestine, colon, testis (but not the ovaries), liver and pancreas.
The KLHL1 protein belongs to a family of actin-organizing proteins related to Drosophila Kelch (Nemes et al., 2000
kelch-like protein 1
, kelch-l like
, Mayven-related protein 2
, kelch-like 1