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Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. Additionally we are shipping Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 4 Proteins (6) and Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 4 Kits (3) and many more products for this protein.
Showing 10 out of 70 products:
Human Polyclonal KIR2DS4 Primary Antibody for IF (p), IHC (p) - ABIN748478
Mozer-Lisewska, Mania, Kowala-Piaskowska, Kluk, Samara, Pauli, ?eromski: Detection and significance of cytotoxic cell subsets in biopsies of HCV-infected human livers. in Archivum immunologiae et therapiae experimentalis 2014
Human Monoclonal KIR2DS4 Primary Antibody for ELISA, WB - ABIN165426
Steffens, Vyas, Dupont, Selvakumar: Nucleotide and amino acid sequence alignment for human killer cell inhibitory receptors (KIR), 1998. in Tissue antigens 1998
genetic association study in population in Eastern India: Data suggest that interactions between KIRs (KIR2DL2 (show KIR2DL2 Antibodies), KIR2DS4, KIR2DL3 (show KIR2DL3 Antibodies)) and HLA ligands (HLAC1, HLAC2) contribute significantly toward susceptibility and protection toward type 1 diabetes.
KIR2DS4 can induce the uptake of CCR7 (show CCR7 Antibodies) by KIR2DS4(+) NKG2A (show KLRC1 Antibodies)(+) natural killer cell clones after interacting with CCR7 (show CCR7 Antibodies)(+) target cells expressing HLA-Cw4 and HLA-Cw6 alleles.
Study shows KIR3DL1 (show KIR3DL1 Antibodies) and KIR2DS4 gene variants are linked and that the gene KIR2DS5 is only present in the telomeric half of the KIR (show GEM Antibodies) locus. Study revealed novel insights in the highly organized distribution of KIR (show GEM Antibodies) genes.
KIR2DS4del presence in patients was associated with severity of endometriosis, which, due to strong negative linkage disequilibrium, may suggest an indirect effect of KIR2DS5 absence
Response of rheumatoid arthritis patients with medium ESR (show ESR1 Antibodies) values to methotrexate treatment may be dependent on the full-length KIR2DS4 gene.
Possession of the functional and non-functional KIR2DS4 isoforms in the mother and the fetus determines the risk of the vertical HIV-1 transmission.
Data indicate that positive linkage disequilibrium was observed between KIR3DL1 (show KIR3DL1 Antibodies), 2DL1, 2DL3 and 2DS4 which is consistent with the associations between the constituents of A haplotypes.
Our data revealed a unique contribution of activating KIRs (KIR2DS4, KIR2DS2 (show KIR2DS2 Antibodies), or KIR3DS1), in addition to NKG2C (show KLRC2 Antibodies), in the expansion of human natural killer cells.
in response to HCT therapy, the activating receptors are also enhanced by a process that increases the number of unmethylated sites present on KIR2DS2 (show KIR2DS2 Antibodies)/4 promoters.
Results suggest a protective role of KIR2DS5 in graft rejection and an association of KIR2DS4 with kidney rejection, particularly in recipients with glomerulonephritis.
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\; thus, KIR proteins are thought to play an important role in regulation of the immune response.
CD158 antigen-like family member I
, KIR antigen 2DS4
, MHC class I NK cell receptor
, P58 natural killer cell receptor clones CL-39/CL-17
, killer cell immunoglobulin-like receptor 2DS4
, killer inhibitory receptor 4-1-2
, natural killer cell inhibitory receptor
, natural killer-associated transcript 8
, p58 NK receptor CL-39/CL-17