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Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. Additionally we are shipping KIR2DL2 Proteins (4) and many more products for this protein.
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association between KIR2DS2 (show KIR2DS2 Antibodies) and the response to methotrexate (MTX (show MTX1 Antibodies)), moreover, the combination KIR2DL2+/KIR2DS2 (show KIR2DS2 Antibodies)+ was more frequent in responders to MTX (show MTX1 Antibodies) (p = 0.043).
KIR2DL2/KIR2DL3 (show KIR2DL3 Antibodies)-glutamate (show GRIN1 Antibodies)(35) alleles are functionally stronger than -glutamine (show GFPT1 Antibodies)(35) alleles.
KIR2DL2/2DS2-C1C1 genotype is associated with type 1 diabetes in Saudi children
genetic association study in population in Eastern India: Data suggest that interactions between KIRs (KIR2DL2, KIR2DS4 (show KIR2DS4 Antibodies), KIR2DL3 (show KIR2DL3 Antibodies)) and HLA ligands (HLAC1, HLAC2) contribute significantly toward susceptibility and protection toward type 1 diabetes.
Allelic polymorphism of KIR2DL2/2DL3 in a southern Chinese population.
a significant increase in the frequency of KIR2DL2 (P = 0.019) as well as KIR2DS2 (show KIR2DS2 Antibodies) (P = 0.008) in patients with neuroblastoma (show ARHGEF16 Antibodies) compared with the healthy control group, was found.
Single Nucleotide Polymorphism in KIR2DL2 gene is associated with Asthma and Atopic Dermatitis.
KIR2DL2 and KIR2DS2 genotype is associated with protection against primary biliary cirrhosis in Han population.
Genetic risk for co-occurrence of type 1 diabetes and celiac disease is modified by HLA-C and killer immunoglobulin-like receptors.
Authors showed an increase in HLA-C1/KIR2DL2 and HLA-C1/KIR2DL3 (show KIR2DL3 Antibodies) pairs in human papillomavirus high-risk infected patients (OR 3.05, 3.24) with invasive cervical cancer (OR 1.33, 3.68).
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\\\\; thus, KIR proteins are thought to play an important role in regulation of the immune response.
CD158 antigen-like family member B1
, MHC class I NK cell receptor
, killer cell immunoglobulin-like receptor 2DL2
, natural killer-associated transcript 6
, p58 NK receptor CL-43
, p58 natural killer cell receptor clone CL-43